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ME-Optogen

Micro-endoscopes for in-depth high-resolution optogenetics

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ME-Optogen" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://lositalianos2018.blogspot.com/2019/05/shining-light-on-brain-me-optogen.html
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

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 Project objective

Understanding how the brain works is one of the grand scientific challenges of our times and constitutes a priority research line for the European Union. The study of the brain mechanisms that underlie fear learning and response is particularly relevant as it could provide the key to control anxiety disorders, with an associated high social and economic benefit for the European community. Recent studies indicate that specific areas of the amygdala, a structure located deep within the brain’s medial temporal lobe, are crucial for the generation of fear responses in mice. To gain more insight, it is now necessary to understand how individual neurons in these areas act and collaborate together to generate the appropriate response. Crucially, this requires the capability to observe and manipulate fear circuits in deep brain structures with single neuron resolution. However, reaching at the same time sufficient depth and high resolution represents a great experimental challenge. At present no technique exists that can enable such a study. The objective of the project is to overcome the current experimental limitations and develop a new optical method for the precise imaging and manipulation of neurons even deep in the brain of living animals. To this end we will extend advanced high-resolution optogenetic stimulation and imaging techniques to an optical micro-endoscope capable of reaching the desired depth in the brain of mice. Proof of principle experiments in vivo in the amygdala of mice will be performed. This highly multidisciplinary project, at the frontiers between optics and neuroscience, will require the great expertise of the host group in optogenetics methods, the strong background of the fellow in high-resolution optical techniques and the collaboration with an external advisor, expert in neurophysiology. The success of this research will provide new powerful tools to study the brain, thus potentiating the European competitiveness in this important field.

 Publications

year authors and title journal last update
List of publications.
2019 Nicolò Accanto, I-Wen Chen, Emiliano Ronzitti, Clément Molinier, Christophe Tourain, Eirini Papagiakoumou, Valentina Emiliani
Multiplexed temporally focused light shaping through a gradient index lens for precise in-depth optogenetic photostimulation
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-43933-w
Scientific Reports 9/1 2019-09-06
2018 Nicolò Accanto, Clément Molinier, Dimitrii Tanese, Emiliano Ronzitti, Zachary L. Newman, Claire Wyart, Ehud Isacoff, Eirini Papagiakoumou, Valentina Emiliani
Multiplexed temporally focused light shaping for high-resolution multi-cell targeting
published pages: 1478, ISSN: 2334-2536, DOI: 10.1364/optica.5.001478
Optica 5/11 2019-09-06

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The information about "ME-OPTOGEN" are provided by the European Opendata Portal: CORDIS opendata.

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