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TEI

Development of a model system to study the role of chromatin factors during transgenerational epigenetic inheritance (TEI) in C. elegans

Total Cost €

EC-Contrib. €

Partnership

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TEI project word cloud

Explore the words cloud of the TEI project. It provides you a very rough idea of what is the project "TEI" about.

silac genome generational transfer marks nuclear elegans insertional dna proteomics caenorhabditis mechanistic conserved time unknown humans discover chromatin rnai spectrometry selfish health non animal genetics toolkit basis invertebrates rna seq days named tei coding pichip organisms assay mammals identification plants proteins rnas linked microbes epigenetic pirna impacts man ptms powerful examples largely inheritance generation public sequence mass model immunoprecipitation transgenerational laboratory histone mechanisms germline transposable

Project "TEI" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-05-01 to 2019-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	183˙454.00

Map

Project objective

Non DNA-sequence based inheritance has been observed in many organisms from microbes to man and likely impacts public health. The mechanisms of non DNA-sequence based inheritance remain largely unknown. However, some examples of non DNA-sequence based inheritance in mammals, plants and invertebrates are linked to the control of selfish, transposable elements in the genome. Here we propose to discover the mechanistic basis of multi-generational non DNA-sequence based inheritance, also referred to as transgenerational epigenetic inheritance (TEI), using the laboratory animal model Caenorhabditis elegans. Specifically, our goal is to identify chromatin and non-coding RNA “epigenetic” marks that transfer information from generation to generation in C. elegans. C. elegans is a great model for this work as it has a generation time of only three days, has a powerful genetics toolkit and its chromatin and RNA pathways are largely conserved in humans. Towards this goal we have established a novel assay we named piRNA-related insertional chromatin immunoprecipitation (piChIP). Using this piChIP system, our specific aims are: Aim-1: Identification of novel non-coding RNAs in the germline nuclear RNAi pathway - Method: RNA-seq Aim-2: Identification of novel proteins and histone PTMs in the germline nuclear RNAi pathway - Method: SILAC proteomics and Mass Spectrometry

Publications

List of publications.
year	authors and title	journal	last update
2019	Chenchun Weng, Joanna Kosalka, Ahmet C. Berkyurek, Przemyslaw Stempor, Xuezhu Feng, Hui Mao, Chenming Zeng, Wen-Jun Li, Yong-Hong Yan, Meng-Qiu Dong, Natalia RosalÃa Morero, Cecilia Zuliani, Orsolya Barabas, Julie Ahringer, Shouhong Guang, Eric A. Miska The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans published pages: 90-102, ISSN: 0890-9369, DOI: 10.1101/gad.319293.118	Genes & Development 33/1-2	2019-09-30
2017	Alper Akay, Tomas Di Domenico, Kin M. Suen, Amena Nabih, Guillermo E. Parada, Mark Larance, Ragini Medhi, Ahmet C. Berkyurek, Xinlian Zhang, Christopher J. Wedeles, Konrad L.M. Rudolph, Jan Engelhardt, Martin Hemberg, Ping Ma, Angus I. Lamond, Julie M. Claycomb, Eric A. Miska The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription published pages: 241-255.e6, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2017.07.002	Developmental Cell 42/3	2019-09-30

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