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TEI

Development of a model system to study the role of chromatin factors during transgenerational epigenetic inheritance (TEI) in C. elegans

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EC-Contrib. €

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Partnership

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Project "TEI" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 183˙454.00

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 Project objective

Non DNA-sequence based inheritance has been observed in many organisms from microbes to man and likely impacts public health. The mechanisms of non DNA-sequence based inheritance remain largely unknown. However, some examples of non DNA-sequence based inheritance in mammals, plants and invertebrates are linked to the control of selfish, transposable elements in the genome. Here we propose to discover the mechanistic basis of multi-generational non DNA-sequence based inheritance, also referred to as transgenerational epigenetic inheritance (TEI), using the laboratory animal model Caenorhabditis elegans. Specifically, our goal is to identify chromatin and non-coding RNA “epigenetic” marks that transfer information from generation to generation in C. elegans. C. elegans is a great model for this work as it has a generation time of only three days, has a powerful genetics toolkit and its chromatin and RNA pathways are largely conserved in humans. Towards this goal we have established a novel assay we named piRNA-related insertional chromatin immunoprecipitation (piChIP). Using this piChIP system, our specific aims are: Aim-1: Identification of novel non-coding RNAs in the germline nuclear RNAi pathway - Method: RNA-seq Aim-2: Identification of novel proteins and histone PTMs in the germline nuclear RNAi pathway - Method: SILAC proteomics and Mass Spectrometry

 Publications

year authors and title journal last update
List of publications.
2019 Chenchun Weng, Joanna Kosalka, Ahmet C. Berkyurek, Przemyslaw Stempor, Xuezhu Feng, Hui Mao, Chenming Zeng, Wen-Jun Li, Yong-Hong Yan, Meng-Qiu Dong, Natalia Rosalía Morero, Cecilia Zuliani, Orsolya Barabas, Julie Ahringer, Shouhong Guang, Eric A. Miska
The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans
published pages: 90-102, ISSN: 0890-9369, DOI: 10.1101/gad.319293.118
Genes & Development 33/1-2 2019-09-30
2017 Alper Akay, Tomas Di Domenico, Kin M. Suen, Amena Nabih, Guillermo E. Parada, Mark Larance, Ragini Medhi, Ahmet C. Berkyurek, Xinlian Zhang, Christopher J. Wedeles, Konrad L.M. Rudolph, Jan Engelhardt, Martin Hemberg, Ping Ma, Angus I. Lamond, Julie M. Claycomb, Eric A. Miska
The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription
published pages: 241-255.e6, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2017.07.002
Developmental Cell 42/3 2019-09-30

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The information about "TEI" are provided by the European Opendata Portal: CORDIS opendata.

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