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FLEXOBONEGRAFT

FLEXOELECTRIC SCAFFOLDS FOR BONE TISSUE ENGINEERING

Total Cost €

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EC-Contrib. €

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Partnership

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Project "FLEXOBONEGRAFT" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA 

Organization address
address: CAMPUS DE LA UAB EDIFICI Q ICN2
city: BELLATERRA (BARCELONA)
postcode: 8193
website: www.icn.cat

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://icn2.cat/en/oxide-nanophysics-group
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-15   to  2019-10-03

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA ES (BELLATERRA (BARCELONA)) coordinator 158˙121.00

Map

 Project objective

'Bone is the most transplanted tissue with 1.3 million procedures every year in Europe. With an increasing demographic ageing across Europe, bone transplant represents a significant socio-economic burden that necessitates new bone regeneration strategies in line with one of the Horizon 2020 priority: 'Smart Growth: knowledge and innovation based economy'. The field of bone tissue engineering has flourished over the last decades, owing to a solid knowledge on bone biology and increased progress on materials engineering. A few weeks ago, Dr Gustau Catalan at ICN2 brought to light the groundbreaking discovery that bone is flexoelectric. In order to biomimic the flexoelectric character of bone, we aim in this project to produce new synthetic bone scaffolds that exhibit flexoelectricity. Engineering scaffolds with a flexoelectric character calls for particular design requirements. Flexoelectricity is the coupling between strain gradients and polarization, whereby any dielectric can polarize in response to an inhomogeneous deformation. In order to generate the required strain gradients within the scaffold to produce a flexoelectric effect, scaffolds will be manufactured with controlled porosity gradients by 3D printing based approaches. Three polymers used in bone tissue engineering, namely PLLA, PLGA and PCL will be investigated to produce the flexoelectric scaffolds. It is envisaged that a flexoelectric-induced polarization can be attained in any of them. In view of improving the osteoconductive, osteogenic and mechanical properties of the flexoelectric scaffolds, they will further incorporate different amounts of nanohydroxyapatite (from 0 to 50 wt %). Finite element calculations will be used to refine porosity geometries (porosity gradient and pore shape). It is expected that through careful geometrical design of porosity, scaffolds could exhibit a bone-like flexoelectric effect that would not only support the bone tissue regeneration process but also stimulate it.'

 Publications

year authors and title journal last update
List of publications.
2020 Raquel Núñez-Toldrà, Fabian Vasquez-Sancho, Nathalie Barroca, Gustau Catalan
Effect of fracture flexoelectricity on bone cells.
published pages: , ISSN: 2045-2322, DOI:
Scientific Reports 2020-03-11

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The information about "FLEXOBONEGRAFT" are provided by the European Opendata Portal: CORDIS opendata.

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