Explore the words cloud of the LABEL-DIOX project. It provides you a very rough idea of what is the project "LABEL-DIOX" about.
The following table provides information about the project.
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
|Coordinator Country||Spain [ES]|
|Total cost||149˙750 €|
|EC max contribution||149˙750 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-12-01 to 2019-05-31|
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|1||FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA||ES (TARRAGONA)||coordinator||149˙750.00|
Absorption, distribution, metabolism and excretion´s studies (ADME) are essential for drug discovery and development, providing invaluable preclinical data to understand how the drug behaves in living organisms, thus allowing to make a decision on whether the drug should be terminated or advanced to the next step. At present, most of these studies are performed with a radiolabelled 14C-labelled version of the drug; unfortunately, current radiolabelling syntheses rely on lengthy-step sequences or rather expensive 14C-labelled building blocks, dramatically raising the costs for the research and development, and delaying the execution of preclinical studies. Taking into consideration that carboxylic acids are privileged motifs in a myriad of agrochemicals or pharmaceuticals, LABEL-DIOX offers the opportunity of promoting a late-stage carboxylation event with labeled CO2. The protocol is user-friendly, with components that are neither air- nor moisture sensitive, utilizes earth-abundant catalysts and operates under mild conditions. LABEL-DIOX will increase the overall efficiency of the carbon isotope incorporation, reduce the costs that would have resulted from the design of a lengthy radiolabelled synthesis, minimize the costs for waste disposal and dramatically increase the revenues, thus changing the way industrial chemists conduct radiolabelling of drugs containing carboxylic acids.
|year||authors and title||journal||last update|
Andreu Tortajada, Yaya Duan, Basudev Sahoo, Fei Cong, Georgios Toupalas, Antoine Sallustrau, Olivier Loreau, Davide Audisio, Ruben Martin
Catalytic Decarboxylation/Carboxylation Platform for Accessing Isotopically Labeled Carboxylic Acids
published pages: 5897-5901, ISSN: 2155-5435, DOI: 10.1021/acscatal.9b01921
|ACS Catalysis 9/7||2019-11-26|
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