The following table provides information about the project.
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
There are not information about this coordinator. Please contact Fabio for more information, thanks.
|Coordinator Country||Spain [ES]|
|Total cost||149˙750 €|
|EC max contribution||149˙750 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-12-01 to 2019-05-31|
Take a look of project's partnership.
|1||FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA||ES (TARRAGONA)||hostInstitution||149˙750.00|
Absorption, distribution, metabolism and excretion´s studies (ADME) are essential for drug discovery and development, providing invaluable preclinical data to understand how the drug behaves in living organisms, thus allowing to make a decision on whether the drug should be terminated or advanced to the next step. At present, most of these studies are performed with a radiolabelled 14C-labelled version of the drug; unfortunately, current radiolabelling syntheses rely on lengthy-step sequences or rather expensive 14C-labelled building blocks, dramatically raising the costs for the research and development, and delaying the execution of preclinical studies. Taking into consideration that carboxylic acids are privileged motifs in a myriad of agrochemicals or pharmaceuticals, LABEL-DIOX offers the opportunity of promoting a late-stage carboxylation event with labeled CO2. The protocol is user-friendly, with components that are neither air- nor moisture sensitive, utilizes earth-abundant catalysts and operates under mild conditions. LABEL-DIOX will increase the overall efficiency of the carbon isotope incorporation, reduce the costs that would have resulted from the design of a lengthy radiolabelled synthesis, minimize the costs for waste disposal and dramatically increase the revenues, thus changing the way industrial chemists conduct radiolabelling of drugs containing carboxylic acids.
Work performed, outcomes and results: advancements report(s)
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The information about "LABEL-DIOX" are provided by the European Opendata Portal: CORDIS opendata.
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