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LABEL-DIOX SIGNED

Late-stage catalytic carboxylation techniques with labelled carbon dioxide: new opportunities for radiolabelling

Total Cost €

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EC-Contrib. €

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Partnership

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 LABEL-DIOX project word cloud

Explore the words cloud of the LABEL-DIOX project. It provides you a very rough idea of what is the project "LABEL-DIOX" about.

dramatically    preclinical    lengthy    label    labelled    drug    radiolabelling    radiolabelled    14c    acids    diox    carboxylic   

Project "LABEL-DIOX" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country Spain [ES]
 Total cost 149˙750 €
 EC max contribution 149˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme /ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) hostInstitution 149˙750.00

Mappa

 Project objective

Absorption, distribution, metabolism and excretion´s studies (ADME) are essential for drug discovery and development, providing invaluable preclinical data to understand how the drug behaves in living organisms, thus allowing to make a decision on whether the drug should be terminated or advanced to the next step. At present, most of these studies are performed with a radiolabelled 14C-labelled version of the drug; unfortunately, current radiolabelling syntheses rely on lengthy-step sequences or rather expensive 14C-labelled building blocks, dramatically raising the costs for the research and development, and delaying the execution of preclinical studies. Taking into consideration that carboxylic acids are privileged motifs in a myriad of agrochemicals or pharmaceuticals, LABEL-DIOX offers the opportunity of promoting a late-stage carboxylation event with labeled CO2. The protocol is user-friendly, with components that are neither air- nor moisture sensitive, utilizes earth-abundant catalysts and operates under mild conditions. LABEL-DIOX will increase the overall efficiency of the carbon isotope incorporation, reduce the costs that would have resulted from the design of a lengthy radiolabelled synthesis, minimize the costs for waste disposal and dramatically increase the revenues, thus changing the way industrial chemists conduct radiolabelling of drugs containing carboxylic acids.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "LABEL-DIOX" are provided by the European Opendata Portal: CORDIS opendata.

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