Explore the words cloud of the DNA ORIGAMI MOTORS project. It provides you a very rough idea of what is the project "DNA ORIGAMI MOTORS" about.
The following table provides information about the project.
TECHNISCHE UNIVERSITAET MUENCHEN
|Coordinator Country||Germany [DE]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-05-01 to 2022-04-30|
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|1||TECHNISCHE UNIVERSITAET MUENCHEN||DE (MUENCHEN)||coordinator||2˙000˙000.00|
Our goal is to advance the field of DNA nanotechnology by achieving directed transport on the nanoscale using robustly functioning synthetic motor units. To do so, we propose to construct spatially periodic, diffusive mechanisms that have broken inversion symmetry and to subject these mechanisms to conditions away from thermal equilibrium. We will build on recent progress in creating complex DNA-based structures and construct various nanoscale rotary and translational Brownian ratchet mechanisms that have well- defined degrees of freedom for motion within periodic and asymmetric energy landscapes. The mechanisms will be self-assembled from DNA origami components. We will use cryo-Transmission Electron Microscopy (TEM) to evaluate and iteratively refine our structures. Conventional video-rate fluorescence microscopy, in addition to super-resolution microscopy, will be employed to study in solution and in real time the diffusive motion of the mechanisms on the single particle level. We will introduce various deterministic or stochastic thermal, mechanical, or chemical perturbations to drive the systems away from thermal equilibrium. We will use laser heating and cooling to experimentally test thermal and flashing ratcheting mechanisms; we will employ dissipative asymmetric fluxes arising in active matter as realized in high-density ATP-hydrolysing motility assays; and we will couple out-of-equilibrium chemical reactions to the motion of our mechanisms. The ultimate goal of our work is to take insights from these experiments and create robustly functioning nanoscale motor units that can drive directed motion against external load and perform at levels comparable to those of natural macromolecular motor proteins. Achieving this goal will create unprecedented technological opportunities, for example, to drive chemical synthesis, actively propel nanoscale drug- delivery vehicles, pump and separate molecules across barriers or package molecules into cargo components.
|year||authors and title||journal||last update|
Thomas Gerling, Hendrik Dietz
Reversible Covalent Stabilization of Stacking Contacts in DNA Assemblies
published pages: 2680-2684, ISSN: 1433-7851, DOI: 10.1002/anie.201812463
|Angewandte Chemie International Edition 58/9||2019-11-22|
Fabian Schneider, Natalie MÃ¶ritz, Hendrik Dietz
The sequence of events during folding of a DNA origami
published pages: eaaw1412, ISSN: 2375-2548, DOI: 10.1126/sciadv.aaw1412
|Science Advances 5/5||2019-11-22|
Katharina HÃ¤uÃŸermann, Gavin Young, Philipp Kukura, Hendrik Dietz
Dissecting FOXP2 Oligomerization and DNA Binding
published pages: 7662-7667, ISSN: 1433-7851, DOI: 10.1002/anie.201901734
|Angewandte Chemie International Edition 58/23||2019-11-22|
Hamid Ramezani, Hendrik Dietz
Building machines with DNA molecules
published pages: , ISSN: 1471-0056, DOI: 10.1038/s41576-019-0175-6
|Nature Reviews Genetics||2019-11-22|
Floris A. S. Engelhardt, Florian Praetorius, Christian H. Wachauf, Gereon BrÃ¼ggenthies, Fabian Kohler, Benjamin Kick, Karoline L. Kadletz, Phuong Nhi Pham, Karl L. Behler, Thomas Gerling, Hendrik Dietz
Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds
published pages: 5015-5027, ISSN: 1936-0851, DOI: 10.1021/acsnano.9b01025
|ACS Nano 13/5||2019-11-22|
Thomas Gerling, Massimo Kube, Benjamin Kick, Hendrik Dietz
Sequence-programmable covalent bonding of designed DNA assemblies
published pages: eaau1157, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1157
|Science Advances 4/8||2019-03-11|
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