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DNA ORIGAMI MOTORS SIGNED

Constructing and powering nanoscale DNA origami motors

Total Cost €

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EC-Contrib. €

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Partnership

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 DNA ORIGAMI MOTORS project word cloud

Explore the words cloud of the DNA ORIGAMI MOTORS project. It provides you a very rough idea of what is the project "DNA ORIGAMI MOTORS" about.

tem    couple    technological    transport    stochastic    hydrolysing    atp    thermal    refine    electron    solution    employ    components    actively    cargo    perturbations    realized    translational    symmetry    resolution    load    progress    assays    transmission    density    origami    mechanisms    diffusive    brownian    broken    away    motion    macromolecular    inversion    laser    reactions    natural    employed    deterministic    video    vehicles    our    landscapes    motor    heating    rate    fluxes    robustly    chemical    drug    insights    subject    create    directed    mechanical    fluorescence    experimentally    ratchet    motility    super    periodic    perform    ratcheting    barriers    structures    freedom    introduce    synthesis    construct    microscopy    asymmetric    particle    synthetic    iteratively    nanotechnology    functioning    assembled    external    units    active    energy    self    unprecedented    ultimate    conventional    pump    experiments    degrees    equilibrium    dna    molecules    levels    drive    flashing    cooling    cryo    rotary    dissipative    separate    time    propel    single    nanoscale    proteins    arising   

Project "DNA ORIGAMI MOTORS" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙000˙000.00

Map

 Project objective

Our goal is to advance the field of DNA nanotechnology by achieving directed transport on the nanoscale using robustly functioning synthetic motor units. To do so, we propose to construct spatially periodic, diffusive mechanisms that have broken inversion symmetry and to subject these mechanisms to conditions away from thermal equilibrium. We will build on recent progress in creating complex DNA-based structures and construct various nanoscale rotary and translational Brownian ratchet mechanisms that have well- defined degrees of freedom for motion within periodic and asymmetric energy landscapes. The mechanisms will be self-assembled from DNA origami components. We will use cryo-Transmission Electron Microscopy (TEM) to evaluate and iteratively refine our structures. Conventional video-rate fluorescence microscopy, in addition to super-resolution microscopy, will be employed to study in solution and in real time the diffusive motion of the mechanisms on the single particle level. We will introduce various deterministic or stochastic thermal, mechanical, or chemical perturbations to drive the systems away from thermal equilibrium. We will use laser heating and cooling to experimentally test thermal and flashing ratcheting mechanisms; we will employ dissipative asymmetric fluxes arising in active matter as realized in high-density ATP-hydrolysing motility assays; and we will couple out-of-equilibrium chemical reactions to the motion of our mechanisms. The ultimate goal of our work is to take insights from these experiments and create robustly functioning nanoscale motor units that can drive directed motion against external load and perform at levels comparable to those of natural macromolecular motor proteins. Achieving this goal will create unprecedented technological opportunities, for example, to drive chemical synthesis, actively propel nanoscale drug- delivery vehicles, pump and separate molecules across barriers or package molecules into cargo components.

 Publications

year authors and title journal last update
List of publications.
2019 Thomas Gerling, Hendrik Dietz
Reversible Covalent Stabilization of Stacking Contacts in DNA Assemblies
published pages: 2680-2684, ISSN: 1433-7851, DOI: 10.1002/anie.201812463
Angewandte Chemie International Edition 58/9 2019-11-22
2019 Fabian Schneider, Natalie Möritz, Hendrik Dietz
The sequence of events during folding of a DNA origami
published pages: eaaw1412, ISSN: 2375-2548, DOI: 10.1126/sciadv.aaw1412
Science Advances 5/5 2019-11-22
2019 Katharina Häußermann, Gavin Young, Philipp Kukura, Hendrik Dietz
Dissecting FOXP2 Oligomerization and DNA Binding
published pages: 7662-7667, ISSN: 1433-7851, DOI: 10.1002/anie.201901734
Angewandte Chemie International Edition 58/23 2019-11-22
2019 Hamid Ramezani, Hendrik Dietz
Building machines with DNA molecules
published pages: , ISSN: 1471-0056, DOI: 10.1038/s41576-019-0175-6
Nature Reviews Genetics 2019-11-22
2019 Floris A. S. Engelhardt, Florian Praetorius, Christian H. Wachauf, Gereon Brüggenthies, Fabian Kohler, Benjamin Kick, Karoline L. Kadletz, Phuong Nhi Pham, Karl L. Behler, Thomas Gerling, Hendrik Dietz
Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds
published pages: 5015-5027, ISSN: 1936-0851, DOI: 10.1021/acsnano.9b01025
ACS Nano 13/5 2019-11-22
2018 Thomas Gerling, Massimo Kube, Benjamin Kick, Hendrik Dietz
Sequence-programmable covalent bonding of designed DNA assemblies
published pages: eaau1157, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1157
Science Advances 4/8 2019-03-11

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