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A novel instrument to identify chiral molecules for pharmaceutics and bio-chemistry.

Total Cost €


EC-Contrib. €






 CHIMERA project word cloud

Explore the words cloud of the CHIMERA project. It provides you a very rough idea of what is the project "CHIMERA" about.

financing    complete    opportunity    competitors    realized    market    thorough    plan    lab    unleashing    indication    differs    advantages    sectors    structural    profitability    start    footprint    decide    fold    signal    pharma    fourier    exist    molecules    external    labs    transform    structure    dna    ground    ones    stimuli    company    strategic    first    spectrum    ultimate    innovation    chiral    device    revolutionary    left    biophysics    object    forms    readiness    stability    conformation    corresponding    chirality    measuring    selecting    spectrometer    extend    prototypes    drug    version    pushing    patenting    industry    mirror    breaking    extremely    tested    technically    drugs    customers    profiling    chimera    proteins    business    instrument    safety    interferometer    validating    hands    employ    aforementioned    price    performing    benchmarking    chemistry    heterodyne    ultra    spectrometers    pharmaceutical    secondary    prototype    uniquely    amplification    content    stable    maturity    right    efficacy    found    drafting    trl9    franchise    patent    biochemistry    plays    3d    image    shrinking    goals    strategy    quality   

Project "CHIMERA" data sheet

The following table provides information about the project.


Organization address
city: MILANO
postcode: 20133

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 149˙375 €
 EC max contribution 149˙375 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2018-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 149˙375.00


 Project objective

This proposal aims at bringing to the market a revolutionary device to uniquely identify the chirality of molecules. An object is chiral if it differs from its mirror image, like our left and right hands. Chirality plays an extremely important role in two main fields: (1) Many drugs are chiral and selecting one of the two forms often enables the pharma industry to extend patent franchise, thus increasing profitability, and to improve the quality, safety and efficacy of the drug. (2) Researchers in the chemistry and biophysics labs use chirality as an indication of the 3D structural conformation of proteins and DNA, to study e.g. their secondary structure and stability under external stimuli. Spectrometers for measuring chirality already exist in the market. Many customers in the two aforementioned sectors could be interested in the new product we propose because it presents several advantages, namely a 2-fold reduction of the price, a 4-fold shrinking of the footprint and an increased information content. The ground-breaking concept (under patenting) behind this new spectrometer is to employ an ultra-stable interferometer to measure the chiral spectrum of molecules via a Fourier-transform approach and a heterodyne amplification of the signal. A first working prototype has already been realized and tested. The CHIMERA project has two main goals. (1) We aim at unleashing the innovation potential of the approach, by technically validating two prototypes in a pharmaceutical company and a biochemistry research lab, thus pushing the Technology Readiness Level of the system to the ultimate maturity required to approach the market, corresponding to TRL9. (2) We will design a complete exploitation plan, performing a thorough analysis of the market, developing a financing strategy, benchmarking our instrument against the competitors’ ones, profiling strategic partners and drafting a first version of a Business Plan to decide on the opportunity to found a start-up company.


year authors and title journal last update
List of publications.
2018 Vikas Kumar, Alejandro De la Cadena, Antonio Perri, Fabrizio Preda, Nicola Coluccelli, Giulio Cerullo, Dario Polli
Invited Article: Complex vibrational susceptibility by interferometric Fourier transform stimulated Raman scattering
published pages: 92403, ISSN: 2378-0967, DOI: 10.1063/1.5034114
APL Photonics 3/9 2019-05-03
2018 Antonio Perri, John H. Gaida, Andrea Farina, Fabrizio Preda, Daniele Viola, Matteo Ballottari, Jürgen Hauer, Sandro De Silvestri, Cosimo D’Andrea, Giulio Cerullo, Dario Polli
Time- and frequency-resolved fluorescence with a single TCSPC detector via a Fourier-transform approach
published pages: 2270, ISSN: 1094-4087, DOI: 10.1364/oe.26.002270
Optics Express 26/3 2019-05-03
2018 Fabrizio Preda, Antonio Perri, Julien Réhault, Biplab Dutta, Jan Helbing, Giulio Cerullo, Dario Polli
Time-domain measurement of optical activity by an ultrastable common-path interferometer
published pages: 1882, ISSN: 0146-9592, DOI: 10.1364/ol.43.001882
Optics Letters 43/8 2019-05-03

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