Explore the words cloud of the METACHROM project. It provides you a very rough idea of what is the project "METACHROM" about.
The following table provides information about the project.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
|Coordinator Country||France [FR]|
|Total cost||1˙999˙025 €|
|EC max contribution||1˙999˙025 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-06-01 to 2022-05-31|
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|1||INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE||FR (PARIS)||coordinator||1˙999˙025.00|
Metastable epialleles are alleles that are variably expressed in genetically identical individuals. These epialleles are established during early development by epigenetic modifications in a process influenced by stress and the environment. The epiallele’s state can subsequently be maintained throughout development and adult life. Studying the mechanisms underlying establishment and maintenance of chromatin states is critical to understanding how the environment can shape the epigenome and how it can impact on diseases and aging. Most mouse metastable epialleles result from a nearby insertion of an endogenous retrovirus, which induces position effect variegation. In mouse embryonic stem cells, these elements are silenced by the histone methyl-transferase SETDB1 which imparts heterochromatin features by tri-methylating histone H3 on lysine 9. In the same cells, telomeric H3K9me3 is also installed by SETDB1 but surprisingly, we found that H3K9me3 correlates with enhanced transcriptional activity at telomeres. I hypothesize here that metastable chromatin states are controlled by H3K9me3 and associated factors, which are targeted to defined positions that can either instruct silencing, or support active expression. To understand how metastable chromatin states are regulated, we will first use a locus-specific chromatin proteomics approach to identify H3K9me3-dependent factors in the contexts of transcription or repression. Next, both pathways will be reconstituted by tethering those factors at specific positions on model genes, and maintenance of these states will be analyzed. Finally, to obtain a comprehensive picture of the metastable states establishment and maintenance, we will map heterochromatin factors genome-wide, in response to distinct stimuli in mESCs. This proposal will deepen our understanding of the mechanisms by which mammals use gene regulation to adapt to environmental conditions.
|year||authors and title||journal||last update|
Mathilde Gauchier, Sophie Kan, Amandine Barral, Sandrine Sauzet, Eneritz Agirre, Erin Bonnell, NehmÃ© Saksouk, Teresa K. Barth, Satoru Ide, Serge Urbach, Raymund J. Wellinger, Reini F. Luco, Axel Imhof, JÃ©rÃ´me DÃ©jardin
SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres
published pages: eaav3673, ISSN: 2375-2548, DOI: 10.1126/sciadv.aav3673
|Science Advances 5/5||2020-02-06|
Sofie Traynor, Niels Erik MÃ¸llegaard, Mikkel G JÃ¸rgensen, Nadine H BrÃ¼ckmann, Christina B Pedersen, Mikkel G Terp, Simone Johansen, Jerome Dejardin, Henrik J Ditzel, Morten F Gjerstorff
Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins
published pages: 6668-6684, ISSN: 0305-1048, DOI: 10.1093/nar/gkz396
|Nucleic Acids Research 47/13||2020-02-06|
Camille Dion, StÃ©phane Roche, Camille LaberthonniÃ¨re, Natacha Broucqsault, Virginie Mariot, Shifeng Xue, Alexandra D Gurzau, Agnieszka Nowak, Christopher T Gordon, Marie-CÃ©cile Gaillard, Claire El-Yazidi, Morgane Thomas, AndrÃ©e Schlupp-Robaglia, Chantal Missirian, ValÃ©rie Malan, Liham Ratbi, Abdelaziz Sefiani, Bernd Wollnik, Bernard Binetruy, Emmanuelle SalortÂ Campana, Shahram Attarian, Rafa
SMCHD1 is involved in de novo methylation of the DUX4 -encoding D4Z4 macrosatellite
published pages: 2822-2839, ISSN: 0305-1048, DOI: 10.1093/nar/gkz005
|Nucleic Acids Research 47/6||2020-02-06|
Mathieu Tardat, JÃ©rÃ´me DÃ©jardin
Telomere chromatin establishment and its maintenance during mammalian development
published pages: 3-18, ISSN: 0009-5915, DOI: 10.1007/s00412-017-0656-3
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