Explore the words cloud of the SynPlex project. It provides you a very rough idea of what is the project "SynPlex" about.
The following table provides information about the project.
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
|Coordinator Country||Switzerland [CH]|
|Total cost||2˙495˙755 €|
|EC max contribution||2˙495˙755 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-08-01 to 2022-07-31|
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|1||EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH||CH (ZUERICH)||coordinator||2˙495˙755.00|
Creating true molecular complexity in a modular, combinatorial fashion is one of the great visions in applied enzymology and chemistry. Nature achieves this feat by using modular biosynthetic enzymes. These microbial proteins generate many of the most important natural products of therapeutic value, including antiinfective, anticancer, and immunosuppressive agents. To construct such compounds, each enzyme module incorporates and often modifies one building block in an assembly line-like process. Among the known modular enzymes, the recently discovered trans-acyltransferase polyketide synthases (trans-AT PKSs) exhibit an unparalleled biosynthetic diversity and tendency to form extensively mosaic-like hybrid enzymes during evolution. As a consequence, many bioactive polyketides generated by these enzymes exhibit combinatorial-like hybrid structures. This phenomenon provides unprecedented opportunities to understand the evolution of metabolic complexity and to apply these principles to metabolic engineering through parts-based synthetic biology. SynPlex will use a novel hypothesis-driven, multi-faceted strategy to interrogate and utilize the distinct combinatorial properties and metabolic richness of trans-AT PKSs. This multidisciplinary project aims to (i) unravel principles of how mosaic PKSs and their metabolites are formed in Nature, (ii) characterize non-canonical PKS components, (iii) create a toolbox of PKS parts for synthetic biology based on these evolutionary and biochemical principles, and (iv) harness the combinatorial potential of trans-AT systems to access complex natural as well as non-natural products. This innovative concept that merges evolutionary biology, enzymology, synthetic biology, and chemistry will result in a broad understanding of these most complex of all known proteins. It has the potential to provide generic, robust synthetic biology platforms to engineer complex polyketides with a wide range of features in a predictable way.
|year||authors and title||journal||last update|
Tetsushi Mori, Jackson K. B. Cahn, Micheal C. Wilson, Roy A. Meoded, Vincent Wiebach, Ana FlÃ¡via Canovas Martinez, Eric J. N. Helfrich, Andreas Albersmeier, Daniel Wibberg, Steven DÃ¤twyler, Ray Keren, Adi Lavy, Christian RÃ¼ckert, Micha Ilan, JÃ¶rn Kalinowski, Shigeki Matsunaga, Haruko Takeyama, JÃ¶rn Piel
Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts
published pages: 1718-1723, ISSN: 0027-8424, DOI: 10.1073/pnas.1715496115
|Proceedings of the National Academy of Sciences 115/8||2020-03-11|
Silke I. Probst, Christine Vogel, Julia A. Vorholt, JÃ¶rn Piel
Genome Mining-guided and MALDI Imaging-assisted Discovery of New Antibiotics
published pages: 816-816, ISSN: 0009-4293, DOI: 10.2533/chimia.2018.816
|CHIMIA International Journal for Chemistry 72/11||2020-03-11|
Thomas A. Scott, JÃ¶rn Piel
The hidden enzymology of bacterial natural product biosynthesis
published pages: 404-425, ISSN: 2397-3358, DOI: 10.1038/s41570-019-0107-1
|Nature Reviews Chemistry 3/7||2020-03-11|
Drew T. Wagner, Zhicheng Zhang, Roy A. Meoded, Alexis J. Cepeda, JÃ¶rn Piel, Adrian T. Keatinge-Clay
Structural and Functional Studies of a Pyran Synthase Domain from a trans -Acyltransferase Assembly Line
published pages: 975-983, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00049
|ACS Chemical Biology 13/4||2019-06-06|
Reiko Ueoka, Agneya Bhushan, Silke I. Probst, Walter M. Bray, R. Scott Lokey, Roger G. Linington, JÃ¶rn Piel
Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source
published pages: 14519-14523, ISSN: 1433-7851, DOI: 10.1002/anie.201805673
|Angewandte Chemie International Edition 57/44||2019-06-06|
Reiko Ueoka, Miriam Bortfeld-Miller, Brandon I. Morinaka, Julia A. Vorholt, JÃ¶rn Piel
Toblerols: Cyclopropanol-Containing Polyketide Modulators of Antibiosis in Methylobacteria
published pages: 977-981, ISSN: 1433-7851, DOI: 10.1002/anie.201709056
|Angewandte Chemie International Edition 57/4||2019-06-06|
Roy A. Meoded, Reiko Ueoka, Eric J. N. Helfrich, Katja Jensen, Nancy Magnus, Birgit Piechulla, JÃ¶rn Piel
A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones
published pages: 11644-11648, ISSN: 1433-7851, DOI: 10.1002/anie.201805363
|Angewandte Chemie International Edition 57/36||2019-06-06|
Brandon I. Morinaka, Edgars Lakis, Marjan Verest, Maximilian J. Helf, Thibault Scalvenzi, Anna L. Vagstad, James Sims, Shinichi Sunagawa, Muriel Gugger, JÃ¶rn Piel
Natural noncanonical protein splicing yields products with diverse Î²-amino acid residues
published pages: 779-782, ISSN: 0036-8075, DOI: 10.1126/science.aao0157
Eric J. N. Helfrich, Christine M. Vogel, Reiko Ueoka, Martin SchÃ¤fer, Florian Ryffel, Daniel B. MÃ¼ller, Silke Probst, Markus Kreuzer, JÃ¶rn Piel, Julia A. Vorholt
Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome
published pages: 909-919, ISSN: 2058-5276, DOI: 10.1038/s41564-018-0200-0
|Nature Microbiology 3/8||2019-06-06|
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