StressGene SIGNED
The Genetics of Morbidity and Survival in Response to Significant Life Stressors
Total Cost €
0EC-Contrib. €
0Partnership
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0StressGene project word cloud
Explore the words cloud of the StressGene project. It provides you a very rough idea of what is the project "StressGene" about.
Project "StressGene" data sheet
The following table provides information about the project.
| Coordinator |
HASKOLI ISLANDS
Organization address contact info |
| Coordinator Country | Iceland [IS] |
| Total cost | 1˙998˙545 € |
| EC max contribution | 1˙998˙543 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-06-01 to 2022-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | HASKOLI ISLANDS | IS (REYKJAVIK) | coordinator | 1˙998˙543.00 |
Map
Project objective
Significant life stressors – including death of loved ones, being diagnosed with a life-threatening illness, and exposure to natural disasters or violence – are well-documented risk factors of ill health, disability and premature mortality. Why some individuals remain healthy while others remiss to adverse symptoms, disease or death after exposure to such life stressors remains unclear. The overarching aim of this research program is to advance current understanding of the potential genetic contribution to varying trajectories of health following exposure to significant life stressors. The program leverages the registries of major diseases and mortality covering the whole Icelandic nation (N=330.000) and the unique genetic- and genealogical resources at deCODE Genetics to perform genome-wide association studies (GWAS) on the varying risks of overall mortality and major diseases (including psychiatric disorders and cardiovascular disease) after loss of a family member or after receiving a cancer diagnosis. We will further seek to identify sequence variants associated with variation in symptoms of posttraumatic stress disorder (PTSD) in two highly traumatized cohorts: the SAGA cohort of 30.000 Icelandic women with high lifetime prevalence of violence exposure, as well as a cohort of 5.000 Swedes exposed to the 2004 SA-Asian Tsunami. This research program represents the first major attempt to address the potential genetic basis of varying somatic health outcomes after exposure to significant life stressors and, to our knowledge, one of the first comprehensive GWAS on PTSD in European populations. Virtually everyone is at some point in their life exposed to significant life stressors or trauma; the knowledge gained from this comprehensive research program may facilitate early identification and refined, personalized interventions for the most vulnerable individuals of the large populations worldwide that inevitably will continue to be exposed to trauma.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Unnur Anna Valdimarsdóttir Ãfalla- og streituraskanir - ein megináskorun lýðheilsuvÃsinda 21.aldar published pages: 543-543, ISSN: 0023-7213, DOI: 10.17992/lbl.2019.12.258 |
Læknablaðið 2019/12 | 2020-02-06 |
| 2019 |
Unnur A Valdimarsdóttir, Donghao Lu, Sigrún H Lund, Katja Fall, Fang Fang, Þórður Kristjánsson, DanÃel Guðbjartsson, Agnar Helgason, Kári Stefánsson The mother’s risk of premature death after child loss across two centuries published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.43476 |
eLife 8 | 2020-02-06 |
| 2019 |
Huan Song, Katja Fall, Fang Fang, Helga Erlendsdóttir, Donghao Lu, David Mataix-Cols, Lorena Fernández de la Cruz, Brian M. D’Onofrio, Paul Lichtenstein, Magnús Gottfreðsson, Catarina Almqvist, Unnur A Valdimarsdóttir Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study published pages: l5784, ISSN: 0959-8138, DOI: 10.1136/bmj.l5784 |
BMJ | 2020-02-06 |
| 2019 |
Huan Song, Fang Fang, Filip K Arnberg, David Mataix-Cols, Lorena Fernández de la Cruz, Catarina Almqvist, Katja Fall, Paul Lichtenstein, Gudmundur Thorgeirsson, Unnur A Valdimarsdóttir Stress related disorders and risk of cardiovascular disease: population based, sibling controlled cohort study published pages: l1255, ISSN: 0959-8138, DOI: 10.1136/bmj.l1255 |
BMJ | 2020-02-06 |
| 2018 |
Huan Song, Fang Fang, Gunnar Tomasson, Filip K. Arnberg, David Mataix-Cols, Lorena Fernández de la Cruz, Catarina Almqvist, Katja Fall, Unnur A. Valdimarsdóttir Association of Stress-Related Disorders With Subsequent Autoimmune Disease published pages: 2388, ISSN: 0098-7484, DOI: 10.1001/jama.2018.7028 |
JAMA 319/23 | 2019-03-12 |
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