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StressGene SIGNED

The Genetics of Morbidity and Survival in Response to Significant Life Stressors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 StressGene project word cloud

Explore the words cloud of the StressGene project. It provides you a very rough idea of what is the project "StressGene" about.

cardiovascular    unclear    personalized    health    life    sequence    stress    risks    disasters    saga    documented    receiving    mortality    continue    ill    2004    identification    vulnerable    lifetime    inevitably    varying    natural    risk    everyone    variation    loved    illness    diagnosed    seek    threatening    nation    worldwide    populations    tsunami    cohorts    posttraumatic    first    330    somatic    contribution    exposure    swedes    registries    disease    basis    diagnosis       psychiatric    perform    diseases    interventions    premature    healthy    point    ptsd    death    symptoms    trauma    asian    significant    virtually    women    disorder    gained    ones    disability    genealogical    sa    trajectories    attempt    remiss    decode    gwas    stressors    variants    outcomes    genetic    traumatized    genetics    individuals    violence    icelandic    adverse    leverages    family    genome    exposed    association    disorders    overarching    cancer    cohort    prevalence    refined   

Project "StressGene" data sheet

The following table provides information about the project.

Coordinator
HASKOLI ISLANDS 

Organization address
address: SAEMUNDARGOTU 2
city: REYKJAVIK
postcode: 101
website: www.hi.is

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Iceland [IS]
 Total cost 1˙998˙545 €
 EC max contribution 1˙998˙543 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HASKOLI ISLANDS IS (REYKJAVIK) coordinator 1˙998˙543.00

Map

 Project objective

Significant life stressors – including death of loved ones, being diagnosed with a life-threatening illness, and exposure to natural disasters or violence – are well-documented risk factors of ill health, disability and premature mortality. Why some individuals remain healthy while others remiss to adverse symptoms, disease or death after exposure to such life stressors remains unclear. The overarching aim of this research program is to advance current understanding of the potential genetic contribution to varying trajectories of health following exposure to significant life stressors. The program leverages the registries of major diseases and mortality covering the whole Icelandic nation (N=330.000) and the unique genetic- and genealogical resources at deCODE Genetics to perform genome-wide association studies (GWAS) on the varying risks of overall mortality and major diseases (including psychiatric disorders and cardiovascular disease) after loss of a family member or after receiving a cancer diagnosis. We will further seek to identify sequence variants associated with variation in symptoms of posttraumatic stress disorder (PTSD) in two highly traumatized cohorts: the SAGA cohort of 30.000 Icelandic women with high lifetime prevalence of violence exposure, as well as a cohort of 5.000 Swedes exposed to the 2004 SA-Asian Tsunami. This research program represents the first major attempt to address the potential genetic basis of varying somatic health outcomes after exposure to significant life stressors and, to our knowledge, one of the first comprehensive GWAS on PTSD in European populations. Virtually everyone is at some point in their life exposed to significant life stressors or trauma; the knowledge gained from this comprehensive research program may facilitate early identification and refined, personalized interventions for the most vulnerable individuals of the large populations worldwide that inevitably will continue to be exposed to trauma.

 Publications

year authors and title journal last update
List of publications.
2019 Unnur Anna Valdimarsdóttir
Áfalla- og streituraskanir - ein megináskorun lýðheilsuvísinda 21.aldar
published pages: 543-543, ISSN: 0023-7213, DOI: 10.17992/lbl.2019.12.258
Læknablaðið 2019/12 2020-02-06
2019 Unnur A Valdimarsdóttir, Donghao Lu, Sigrún H Lund, Katja Fall, Fang Fang, Þórður Kristjánsson, Daníel Guðbjartsson, Agnar Helgason, Kári Stefánsson
The mother’s risk of premature death after child loss across two centuries
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.43476
eLife 8 2020-02-06
2019 Huan Song, Katja Fall, Fang Fang, Helga Erlendsdóttir, Donghao Lu, David Mataix-Cols, Lorena Fernández de la Cruz, Brian M. D’Onofrio, Paul Lichtenstein, Magnús Gottfreðsson, Catarina Almqvist, Unnur A Valdimarsdóttir
Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study
published pages: l5784, ISSN: 0959-8138, DOI: 10.1136/bmj.l5784
BMJ 2020-02-06
2019 Huan Song, Fang Fang, Filip K Arnberg, David Mataix-Cols, Lorena Fernández de la Cruz, Catarina Almqvist, Katja Fall, Paul Lichtenstein, Gudmundur Thorgeirsson, Unnur A Valdimarsdóttir
Stress related disorders and risk of cardiovascular disease: population based, sibling controlled cohort study
published pages: l1255, ISSN: 0959-8138, DOI: 10.1136/bmj.l1255
BMJ 2020-02-06
2018 Huan Song, Fang Fang, Gunnar Tomasson, Filip K. Arnberg, David Mataix-Cols, Lorena Fernández de la Cruz, Catarina Almqvist, Katja Fall, Unnur A. Valdimarsdóttir
Association of Stress-Related Disorders With Subsequent Autoimmune Disease
published pages: 2388, ISSN: 0098-7484, DOI: 10.1001/jama.2018.7028
JAMA 319/23 2019-03-12

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The information about "STRESSGENE" are provided by the European Opendata Portal: CORDIS opendata.

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