Explore the words cloud of the StressGene project. It provides you a very rough idea of what is the project "StressGene" about.
The following table provides information about the project.
|Coordinator Country||Iceland [IS]|
|Total cost||1˙998˙545 €|
|EC max contribution||1˙998˙543 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-06-01 to 2022-05-31|
Take a look of project's partnership.
|1||HASKOLI ISLANDS||IS (REYKJAVIK)||coordinator||1˙998˙543.00|
Significant life stressors – including death of loved ones, being diagnosed with a life-threatening illness, and exposure to natural disasters or violence – are well-documented risk factors of ill health, disability and premature mortality. Why some individuals remain healthy while others remiss to adverse symptoms, disease or death after exposure to such life stressors remains unclear. The overarching aim of this research program is to advance current understanding of the potential genetic contribution to varying trajectories of health following exposure to significant life stressors. The program leverages the registries of major diseases and mortality covering the whole Icelandic nation (N=330.000) and the unique genetic- and genealogical resources at deCODE Genetics to perform genome-wide association studies (GWAS) on the varying risks of overall mortality and major diseases (including psychiatric disorders and cardiovascular disease) after loss of a family member or after receiving a cancer diagnosis. We will further seek to identify sequence variants associated with variation in symptoms of posttraumatic stress disorder (PTSD) in two highly traumatized cohorts: the SAGA cohort of 30.000 Icelandic women with high lifetime prevalence of violence exposure, as well as a cohort of 5.000 Swedes exposed to the 2004 SA-Asian Tsunami. This research program represents the first major attempt to address the potential genetic basis of varying somatic health outcomes after exposure to significant life stressors and, to our knowledge, one of the first comprehensive GWAS on PTSD in European populations. Virtually everyone is at some point in their life exposed to significant life stressors or trauma; the knowledge gained from this comprehensive research program may facilitate early identification and refined, personalized interventions for the most vulnerable individuals of the large populations worldwide that inevitably will continue to be exposed to trauma.
|year||authors and title||journal||last update|
Unnur Anna ValdimarsdÃ³ttir
Ãfalla- og streituraskanir - ein meginÃ¡skorun lÃ½Ã°heilsuvÃsinda 21.aldar
published pages: 543-543, ISSN: 0023-7213, DOI: 10.17992/lbl.2019.12.258
Unnur A ValdimarsdÃ³ttir, Donghao Lu, SigrÃºn H Lund, Katja Fall, Fang Fang, ÃžÃ³rÃ°ur KristjÃ¡nsson, DanÃel GuÃ°bjartsson, Agnar Helgason, KÃ¡ri StefÃ¡nsson
The motherâ€™s risk of premature death after child loss across two centuries
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.43476
Huan Song, Katja Fall, Fang Fang, Helga ErlendsdÃ³ttir, Donghao Lu, David Mataix-Cols, Lorena FernÃ¡ndez de la Cruz, Brian M. Dâ€™Onofrio, Paul Lichtenstein, MagnÃºs GottfreÃ°sson, Catarina Almqvist, Unnur A ValdimarsdÃ³ttir
Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study
published pages: l5784, ISSN: 0959-8138, DOI: 10.1136/bmj.l5784
Huan Song, Fang Fang, Filip K Arnberg, David Mataix-Cols, Lorena FernÃ¡ndez de la Cruz, Catarina Almqvist, Katja Fall, Paul Lichtenstein, Gudmundur Thorgeirsson, Unnur A ValdimarsdÃ³ttir
Stress related disorders and risk of cardiovascular disease: population based, sibling controlled cohort study
published pages: l1255, ISSN: 0959-8138, DOI: 10.1136/bmj.l1255
Huan Song, Fang Fang, Gunnar Tomasson, Filip K. Arnberg, David Mataix-Cols, Lorena FernÃ¡ndez de la Cruz, Catarina Almqvist, Katja Fall, Unnur A. ValdimarsdÃ³ttir
Association of Stress-Related Disorders With Subsequent Autoimmune Disease
published pages: 2388, ISSN: 0098-7484, DOI: 10.1001/jama.2018.7028
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The information about "STRESSGENE" are provided by the European Opendata Portal: CORDIS opendata.