Explore the words cloud of the MECSPEC project. It provides you a very rough idea of what is the project "MECSPEC" about.
The following table provides information about the project.
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
|Coordinator Country||Austria [AT]|
|Total cost||2˙306˙862 €|
|EC max contribution||2˙306˙862 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-07-01 to 2022-06-30|
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|1||INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA||AT (KLOSTERNEUBURG)||coordinator||2˙306˙862.00|
Embryogenesis is achieved by the close interplay between the gene regulatory networks that control cell fate specification and the physical processes by which the embryo takes shape. While each of these systems has been extensively investigated over the past decades, comparably little is yet known about how they functionally interact across different scales of organization within the physiological context of the developing embryo. The central aim of this proposal is to elucidate the fundamental principles underlying the interaction and feedback between cell mechanics and fate specification during vertebrate gastrulation. Using zebrafish as a vertebrate model organism, we will explore how germ layer progenitor cell fate specification affects the physical processes by which the gastrula takes shape, and, vice versa, how alterations in cell/tissue mechanics feed back onto the gene regulatory networks and signals controlling progenitor cell fate specification during gastrulation. To dissect the fundamental mechanisms underlying this crosstalk, we will combine genetic, cell biological and biophysical experimentation with mathematical modeling. We expect that this transdisciplinary approach will provide answers to a central yet unresolved question in developmental biology: how the interplay between cell mechanics, dynamics and fate specification drives embryo morphogenesis and patterning.
|year||authors and title||journal||last update|
Nicoletta I Petridou, Carlâ€Philipp Heisenberg
Tissue rheology in embryonic organization
published pages: , ISSN: 0261-4189, DOI: 10.15252/embj.2019102497
|The EMBO Journal 38/20||2020-03-24|
Shayan Shamipour, Roland Kardos, Shi-Lei Xue, BjÃ¶rn Hof, Edouard Hannezo, Carl-Philipp Heisenberg
Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes
published pages: 1463-1479.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.04.030
Edouard Hannezo, Carl-Philipp Heisenberg
Mechanochemical Feedback Loops in Development and Disease
published pages: 12-25, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.05.052
Daniel ÄŒapek, Michael Smutny, Alexandra-Madelaine Tichy, Maurizio Morri, Harald Janovjak, Carl-Philipp Heisenberg
Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.42093
Cornelia Schwayer, Shayan Shamipour, Kornelija Pranjic-Ferscha, Alexandra Schauer, Maria Balda, Masazumi Tada, Karl Matter, Carl-Philipp Heisenberg
Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow
published pages: 937-952.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.10.006
Nicoletta I. Petridou, Silvia Grigolon, Guillaume Salbreux, Edouard Hannezo, Carl-Philipp Heisenberg
Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling
published pages: 169-178, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0247-4
|Nature Cell Biology 21/2||2020-03-24|
Peng Xia, Daniel GÃ¼tl, Vanessa Zheden, Carl-Philipp Heisenberg
Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity
published pages: , ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.01.019
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