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FunCoSpeedSpine SIGNED

Mapping the functional connectome for speed control in spinal motor circuits

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FunCoSpeedSpine project word cloud

Explore the words cloud of the FunCoSpeedSpine project. It provides you a very rough idea of what is the project "FunCoSpeedSpine" about.

networks    tackle    vivo    right    career    young    clamp    hindbrain    made    independent    divergence    map    slow    questions    neurons    efforts    prolific    electrophysiology    optical    locomotor    govern    cells    premotor    answer    pattern    circuits    connectivity    speed    lab    excitatory    fluorescent    effort    recordings    revealed    patterns    direct    motor    underlying    calcium    connections    v2a    segregate    functional    larva    record    paris    spanning    connectome    optogenetics    cord    talented    wyart    piecemeal    track    expertise    fast    imaging    zebrafish    muscle    little    resolve    spinal    brain    genetically    environment    supraspinal    modulating    publications    skills    convergence    degree    light    3d    advantage    nexus    history    carry    patch    scientist    stimulation    launch    network    combining    act    inputs    recruitment    spine    interneurons    v2as    synaptic    patterning    locomotion    connection    clarity   

Project "FunCoSpeedSpine" data sheet

The following table provides information about the project.

Coordinator
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE 

Organization address
address: BOULEVARD DE L'HOPITAL 47
city: PARIS
postcode: 75013
website: http://icm-institute.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

The study of spinal circuits underlying locomotion has a rich history, spanning over 100 years of research. Great efforts have been made to map out the connection patterns between motor neurons and different muscle targets. Yet, we know little about how premotor networks govern the recruitment of motor neurons and the control of speed. Recent advances in optogenetics, 3D light patterning and fluorescent-targeted patch clamp recordings of identified neurons now enable to map the functional connectome for speed control in spinal motor circuits. Here we will focus on the role of V2a excitatory premotor interneurons since these cells have the potential to act as a key nexus in the spinal network: i) spanning both in the hindbrain and spinal cord, ii) making direct connections with motor neurons and iii) modulating locomotor speed. Recent studies revealed piecemeal information related to the V2a to motor neurons connection pattern. By taking advantage of the optical clarity of the zebrafish larva, we will implement a comprehensive approach combining in vivo electrophysiology, state-of-the-art 3D optical stimulation of genetically targeted cells and functional calcium imaging to resolve the connectivity map of V2a neurons and answer 3 new key questions: 1. What are the synaptic connections among V2as and between V2a and motor neurons within both slow and fast locomotion? 2. What is the degree of convergence and divergence between V2a neurons and motor neurons? 3. Do supraspinal inputs to the spinal cord segregate based on speed? A talented young scientist, with a great track record and the right expertise to tackle these ambitious questions, will carry out the project in the prolific research environment offered by the Wyart lab at the Brain and Spine Institute in Paris. This effort will lead to high impact publications as well as to develop the necessary skills to launch an independent research career for the applicant.

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The information about "FUNCOSPEEDSPINE" are provided by the European Opendata Portal: CORDIS opendata.

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