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FunCoSpeedSpine SIGNED

Mapping the functional connectome for speed control in spinal motor circuits

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FunCoSpeedSpine project word cloud

Explore the words cloud of the FunCoSpeedSpine project. It provides you a very rough idea of what is the project "FunCoSpeedSpine" about.

functional    environment    light    piecemeal    zebrafish    answer    connectivity    fast    synaptic    imaging    clarity    larva    history    genetically    underlying    lab    spinal    vivo    supraspinal    network    paris    govern    convergence    young    questions    divergence    locomotor    act    brain    effort    efforts    cord    prolific    3d    recruitment    optical    combining    optogenetics    inputs    motor    resolve    revealed    spine    spanning    v2a    talented    patterns    record    little    wyart    slow    clamp    tackle    connection    connections    independent    patterning    direct    publications    made    v2as    premotor    hindbrain    track    skills    calcium    networks    modulating    muscle    neurons    expertise    circuits    advantage    carry    cells    nexus    fluorescent    map    patch    segregate    connectome    locomotion    excitatory    pattern    right    interneurons    speed    electrophysiology    stimulation    launch    degree    recordings    career    scientist   

Project "FunCoSpeedSpine" data sheet

The following table provides information about the project.

Coordinator
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE 

Organization address
address: BOULEVARD DE L'HOPITAL 47
city: PARIS
postcode: 75013
website: http://icm-institute.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

The study of spinal circuits underlying locomotion has a rich history, spanning over 100 years of research. Great efforts have been made to map out the connection patterns between motor neurons and different muscle targets. Yet, we know little about how premotor networks govern the recruitment of motor neurons and the control of speed. Recent advances in optogenetics, 3D light patterning and fluorescent-targeted patch clamp recordings of identified neurons now enable to map the functional connectome for speed control in spinal motor circuits. Here we will focus on the role of V2a excitatory premotor interneurons since these cells have the potential to act as a key nexus in the spinal network: i) spanning both in the hindbrain and spinal cord, ii) making direct connections with motor neurons and iii) modulating locomotor speed. Recent studies revealed piecemeal information related to the V2a to motor neurons connection pattern. By taking advantage of the optical clarity of the zebrafish larva, we will implement a comprehensive approach combining in vivo electrophysiology, state-of-the-art 3D optical stimulation of genetically targeted cells and functional calcium imaging to resolve the connectivity map of V2a neurons and answer 3 new key questions: 1. What are the synaptic connections among V2as and between V2a and motor neurons within both slow and fast locomotion? 2. What is the degree of convergence and divergence between V2a neurons and motor neurons? 3. Do supraspinal inputs to the spinal cord segregate based on speed? A talented young scientist, with a great track record and the right expertise to tackle these ambitious questions, will carry out the project in the prolific research environment offered by the Wyart lab at the Brain and Spine Institute in Paris. This effort will lead to high impact publications as well as to develop the necessary skills to launch an independent research career for the applicant.

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The information about "FUNCOSPEEDSPINE" are provided by the European Opendata Portal: CORDIS opendata.

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