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NeuroRibo SIGNED

Specialized Ribosomes for Neuronal Protein Synthesis

Total Cost €


EC-Contrib. €






Project "NeuroRibo" data sheet

The following table provides information about the project.


Organization address
city: Munich
postcode: 80539

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙348˙483 €
 EC max contribution 2˙348˙483 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2022-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The ability of the nervous system to respond adaptively relies on modifications to existing proteins as well as changes in gene transcription and mRNA translation. It is now clear that synapses possess the capacity for local protein synthesis, owing to the localization of ribosomes and mRNAs within dendrites. There is emerging interest in the possibility that ribosomes, as cellular machines, are not as static as typically assumed- and may be heterogeneous in composition and specialized for particular functions and cellular compartments. Intriguingly, several studies have noted the presence of ribosomal protein mRNAs in the dendrites and axons, raising the possibility that locally synthesized ribosomal proteins might serve to modify the local ribosome population. Amongst the players in protein synthesis, many signaling proteins, RNA-binding proteins, and most translation factors have been considered as potential regulatory hubs. The ribosomes, thus far, have not been considered. Here we propose to discover the nature and diversity of ribosomes present in neurons, their dendrites and their synapses in the rodent brain. Using a combination of RNA-sequencing, Mass Spectrometry, Fluorescence In situ Hybridization, and new labelling approaches to visualize nascent proteins, we will determine whether neuronal ribosomes are heterogeneous and specialized in different subcellular compartments. The proposed experiments will determine the relationship between the ribosome composition and the neuronal mRNAs that undergo translation. We will also examine how plasticity sculpts the ribosome population to regulate the changes in the proteome that are dynamically regulated by ongoing synaptic events and plasticity.


year authors and title journal last update
List of publications.
2019 Christine E. Holt, Kelsey C. Martin, Erin M. Schuman
Local translation in neurons: visualization and function
published pages: 557-566, ISSN: 1545-9993, DOI: 10.1038/s41594-019-0263-5
Nature Structural & Molecular Biology 26/7 2020-04-01
2020 Anne Biever, Caspar Glock, Georgi Tushev, Elena Ciirdaeva, Tamas Dalmay, Julian D. Langer, Erin M. Schuman
Monosomes actively translate synaptic mRNAs in neuronal processes
published pages: eaay4991, ISSN: 0036-8075, DOI: 10.1126/science.aay4991
Science 367/6477 2020-04-01
2019 Mantian Wang, Jingyi Hou, Michaela Müller-McNicoll, Wei Chen, Erin M. Schuman
Long and Repeat-Rich Intronic Sequences Favor Circular RNA Formation under Conditions of Reduced Spliceosome Activity
published pages: 237-247, ISSN: 2589-0042, DOI: 10.1016/j.isci.2019.08.058
iScience 20 2020-04-01
2019 Anne-Sophie Hafner, Paul G. Donlin-Asp, Beulah Leitch, Etienne Herzog, Erin M. Schuman
Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments
published pages: eaau3644, ISSN: 0036-8075, DOI: 10.1126/science.aau3644
Science 364/6441 2020-02-13
2019 Beatriz Alvarez-Castelao, Christoph T. Schanzenbächer, Julian D. Langer, Erin M. Schuman
Cell-type-specific metabolic labeling, detection and identification of nascent proteomes in vivo
published pages: 556-575, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0106-6
Nature Protocols 14/2 2019-06-03
2018 Georgi Tushev, Caspar Glock, Maximilian Heumüller, Anne Biever, Marko Jovanovic, Erin M. Schuman
Alternative 3′ UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments
published pages: 495-511.e6, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.03.030
Neuron 98/3 2019-06-03
2018 Aline R Dörrbaum, Lisa Kochen, Julian D Langer, Erin M Schuman
Local and global influences on protein turnover in neurons and glia
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.34202
eLife 7 2019-06-03
2019 Vidhya Rangaraju, Marcel Lauterbach, Erin M. Schuman
Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity
published pages: 73-84.e15, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.12.013
Cell 176/1-2 2019-03-11

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