Explore the words cloud of the NeuroRibo project. It provides you a very rough idea of what is the project "NeuroRibo" about.
The following table provides information about the project.
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
|Coordinator Country||Germany [DE]|
|Total cost||2˙348˙483 €|
|EC max contribution||2˙348˙483 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-08-01 to 2022-07-31|
Take a look of project's partnership.
|1||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (Munich)||coordinator||2˙348˙483.00|
The ability of the nervous system to respond adaptively relies on modifications to existing proteins as well as changes in gene transcription and mRNA translation. It is now clear that synapses possess the capacity for local protein synthesis, owing to the localization of ribosomes and mRNAs within dendrites. There is emerging interest in the possibility that ribosomes, as cellular machines, are not as static as typically assumed- and may be heterogeneous in composition and specialized for particular functions and cellular compartments. Intriguingly, several studies have noted the presence of ribosomal protein mRNAs in the dendrites and axons, raising the possibility that locally synthesized ribosomal proteins might serve to modify the local ribosome population. Amongst the players in protein synthesis, many signaling proteins, RNA-binding proteins, and most translation factors have been considered as potential regulatory hubs. The ribosomes, thus far, have not been considered. Here we propose to discover the nature and diversity of ribosomes present in neurons, their dendrites and their synapses in the rodent brain. Using a combination of RNA-sequencing, Mass Spectrometry, Fluorescence In situ Hybridization, and new labelling approaches to visualize nascent proteins, we will determine whether neuronal ribosomes are heterogeneous and specialized in different subcellular compartments. The proposed experiments will determine the relationship between the ribosome composition and the neuronal mRNAs that undergo translation. We will also examine how plasticity sculpts the ribosome population to regulate the changes in the proteome that are dynamically regulated by ongoing synaptic events and plasticity.
|year||authors and title||journal||last update|
Christine E. Holt, Kelsey C. Martin, Erin M. Schuman
Local translation in neurons: visualization and function
published pages: 557-566, ISSN: 1545-9993, DOI: 10.1038/s41594-019-0263-5
|Nature Structural & Molecular Biology 26/7||2020-04-01|
Anne Biever, Caspar Glock, Georgi Tushev, Elena Ciirdaeva, Tamas Dalmay, Julian D. Langer, Erin M. Schuman
Monosomes actively translate synaptic mRNAs in neuronal processes
published pages: eaay4991, ISSN: 0036-8075, DOI: 10.1126/science.aay4991
Mantian Wang, Jingyi Hou, Michaela MÃ¼ller-McNicoll, Wei Chen, Erin M. Schuman
Long and Repeat-Rich Intronic Sequences Favor Circular RNA Formation under Conditions of Reduced Spliceosome Activity
published pages: 237-247, ISSN: 2589-0042, DOI: 10.1016/j.isci.2019.08.058
Anne-Sophie Hafner, Paul G. Donlin-Asp, Beulah Leitch, Etienne Herzog, Erin M. Schuman
Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments
published pages: eaau3644, ISSN: 0036-8075, DOI: 10.1126/science.aau3644
Beatriz Alvarez-Castelao, Christoph T. SchanzenbÃ¤cher, Julian D. Langer, Erin M. Schuman
Cell-type-specific metabolic labeling, detection and identification of nascent proteomes in vivo
published pages: 556-575, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0106-6
|Nature Protocols 14/2||2019-06-03|
Georgi Tushev, Caspar Glock, Maximilian HeumÃ¼ller, Anne Biever, Marko Jovanovic, Erin M. Schuman
Alternative 3â€² UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments
published pages: 495-511.e6, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.03.030
Aline R DÃ¶rrbaum, Lisa Kochen, Julian D Langer, Erin M Schuman
Local and global influences on protein turnover in neurons and glia
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.34202
Vidhya Rangaraju, Marcel Lauterbach, Erin M. Schuman
Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity
published pages: 73-84.e15, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.12.013
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The information about "NEURORIBO" are provided by the European Opendata Portal: CORDIS opendata.
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