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Tumor-Treg-Targeting SIGNED

Training Network for the education of the next generation scientist in targeting the supressive capacity of regulatory T-cells specifically within tumours

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Tumor-Treg-Targeting project word cloud

Explore the words cloud of the Tumor-Treg-Targeting project. It provides you a very rough idea of what is the project "Tumor-Treg-Targeting" about.

recent    cells    patients    therapy    antibody    generation    clinical    cell    tumours    inhibitors    tregs    cancer    suppressive    tumour    local    regulatory    immune    efficacy    environment   

Project "Tumor-Treg-Targeting" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE NAVARRA 

Organization address
address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL
city: PAMPLONA
postcode: 31080
website: www.unav.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙279˙782 €
 EC max contribution 1˙279˙782 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme /MSCA-ITN-EID
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE NAVARRA ES (PAMPLONA) coordinator 247˙872.00
2    ADURO BIOTECH EUROPE BV NL (OSS) participant 510˙748.00
3    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 273˙287.00
4    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA ES (PAMPLONA) participant 247˙872.00
5    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) partner 0.00
6    iOMEDICO AG DE (Freiburg) partner 0.00

Mappa

 Project objective

Tumour immune-therapy has made dramatic improvements in recent years, saving the lives of cancer patients who just a few years ago would have been considered untreatable. It thereby became apparent that one specific type of immune cell, so called regulatory T-cells, critically hampers the efficacy of tumour immune-therapy. Tumours, however, attract and exploit the immune-regulatory function of Tregs to dampen local immune responses and to induce local tolerance. In recent years, inhibitors that directly target immune-suppressive mechanisms of T cells have found clinical application with great success. The clinical application of these so called “check-point inhibitors”, however, is accompanied by severe side effects in treated patients. Thus improvement of the efficacy of current immune-therapeutic treatments is a major unmet need. This proposal will employ the newest developments in antibody design to target the next generation of biologics right towards tumour-residential Tregs or directly into the tumour micro-environment itself. In this way we will be able to specifically shift the local immune suppressive environment within tumours, while leaving tissue homeostasis in noncancerous tissues unaffected, and thus diminish treatment associated side-effects. The here proposed project combines the expertise of fundamental immunologist, tumour immunologists and cell biologists with that of a life-science biotechnology company and that of experts in clinical cancer research to address this aspect. This group will lead a training network that aims at educating a new generation of researchers, who will be able to bridge the innovation gap between, on the one hand, early discoveries in tumour-immunology as well as in antibody technology and, on the other hand, the efficient translation and clinical validations of these findings in patients.

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The information about "TUMOR-TREG-TARGETING" are provided by the European Opendata Portal: CORDIS opendata.

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