Explore the words cloud of the EVOdrops project. It provides you a very rough idea of what is the project "EVOdrops" about.
The following table provides information about the project.
UNIVERSITY OF GLASGOW
|Coordinator Country||United Kingdom [UK]|
|Total cost||3˙452˙422 €|
|EC max contribution||3˙452˙422 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2018-10-01 to 2022-09-30|
Take a look of project's partnership.
|1||UNIVERSITY OF GLASGOW||UK (GLASGOW)||coordinator||606˙345.00|
|2||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||participant||527˙543.00|
|3||THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE||UK (CAMBRIDGE)||participant||303˙172.00|
|4||EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH||CH (ZUERICH)||participant||281˙276.00|
|6||UNIVERSITE DE PARIS||FR (PARIS)||participant||274˙802.00|
|7||UNIVERSITE CATHOLIQUE DE LOUVAIN||BE (LOUVAIN LA NEUVE)||participant||256˙320.00|
|8||TECHNISCHE UNIVERSITAET MUENCHEN||DE (MUENCHEN)||participant||252˙788.00|
|9||INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK||PL (WARSZAWA)||participant||227˙478.00|
|10||UAB THERMO FISHER SCIENTIFIC BALTICS||LT (VILNIUS)||participant||223˙947.00|
|11||VILNIAUS UNIVERSITETAS||LT (VILNIUS)||participant||223˙947.00|
|12||UNIVERSITE PARIS DESCARTES||FR (PARIS CEDEX 06)||participant||0.00|
|13||BASF SE||DE (LUDWIGSHAFEN AM RHEIN)||partner||0.00|
|14||BLACKTRACE HOLDINGS LIMITED||UK (ROYSTON)||partner||0.00|
|15||DROP-TECH LTD||UK (Cambridge)||partner||0.00|
|16||ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS||FR (PARIS)||partner||0.00|
|17||MICROFLUIDIC CHIPSHOP GMBH||DE (JENA)||partner||0.00|
|18||PRESIDENT AND FELLOWS OF HARVARD COLLEGE||US (CAMBRIDGE)||partner||0.00|
|19||SPHERE FLUIDICS LIMITED||UK (BABRAHAM CAMBRIDGE)||partner||0.00|
|20||THE UNIVERSITY OF HONG KONG||HK (Pokfulam)||partner||0.00|
Natural evolution is a powerful process that has given rise to the functionally diverse set of proteins present in all living systems. Repetitive rounds of mutation, selection and amplification have optimised nature’s catalysts, the enzymes, to perform an enormous range of different reactions. However, natural evolution has driven the optimisation of enzymes subjected to living functions of microorganisms, according to ill-defined and fluctuating external conditions and is not suitable for industrial processes since it lacks of control of selection pressure. In EVOdrops, we will use directed evolution to overcome these limitations. It is a synthetic, man-made approach of evolution, aiming at improving living systems based on predefined needs, controlling the external selection pressure. While natural evolution took billions of years to optimise macromolecules, directed evolution – to be efficient in an industrial process – requires both the generation of genetic diversity and ultra-high throughput screening capabilities to recover the variants of interest. We will develop and optimise these tools using the ground-breaking potential of droplet-based microfluidics for high-throughput experimentation and the fine control of gene library construction. EVOdrops, a European training network, will bring together the leading research scientists, laboratories and industries in Europe with outstanding expertise in protein engineering and microfluidics and 13 early stage researchers. We will offer an extensive multi- and interdisciplinary training to ensure that they can solve these urgent and unmet challenges in biotechnology and biomedicine. We will use a multidisciplinary approach combining soft matter, microfluidics and chemical biology to design solutions for the selection of new enzymes of industrial and therapeutic interest. In the future, our approaches can be generalised to challenges involving high-throughput miniaturised biochemical or cell-based assays.
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The information about "EVODROPS" are provided by the European Opendata Portal: CORDIS opendata.