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EVOdrops SIGNED

directed EVOlution in DROPS

Total Cost €

EC-Contrib. €

Partnership

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EVOdrops project word cloud

Explore the words cloud of the EVOdrops project. It provides you a very rough idea of what is the project "EVOdrops" about.

training assays mutation biotechnology expertise protein microorganisms overcome optimisation limitations evolution screening variants cell billions external combining biochemical laboratories fluctuating reactions therapeutic man engineering enzymes powerful industries diverse perform genetic optimise ill repetitive predefined proteins construction took scientists chemical library macromolecules nature of suitable droplet generation recover amplification pressure miniaturised stage experimentation generalised made soft microfluidics multidisciplinary diversity biomedicine gene natural throughput lacks synthetic directed tools enormous breaking subjected industrial functionally catalysts evodrops living urgent 13 unmet functions network efficient ultra solutions outstanding ground extensive rounds fine interdisciplinary biology

Project "EVOdrops" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	3˙452˙422 €
EC max contribution	3˙452˙422 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2018
Funding Scheme	MSCA-ITN-ETN
Starting year	2018
Duration (year-month-day)	from 2018-10-01 to 2022-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	coordinator	606˙345.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	527˙543.00
3	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	303˙172.00
4	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	281˙276.00
5	BIOMILLENIA BIOMILLENIA Organization address address: 102 AVENUE GASTON ROUSSEL BIOCITECH city: ROMAINVILLE postcode: 93230 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ROMAINVILLE)	participant	274˙802.00
6	UNIVERSITE DE PARIS UNIVERSITE DE PARIS Organization address address: 85 BD SAINT GERMAIN city: PARIS postcode: 75006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	274˙802.00
7	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	participant	256˙320.00
8	TECHNISCHE UNIVERSITAET MUENCHEN TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	252˙788.00
9	INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK Organization address address: KASPRZAKA 44/52 city: WARSZAWA postcode: 1224 website: http://www.ichf.edu.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (WARSZAWA)	participant	227˙478.00
10	UAB THERMO FISHER SCIENTIFIC BALTICS UAB THERMO FISHER SCIENTIFIC BALTICS Organization address address: V.Graiciuno 8 city: VILNIUS postcode: 2241 website: www.fermentas.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LT (VILNIUS)	participant	223˙947.00
11	VILNIAUS UNIVERSITETAS VILNIAUS UNIVERSITETAS Organization address address: UNIVERSITETO G. 3 city: VILNIUS postcode: 1513 website: http://www.vu.lt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LT (VILNIUS)	participant	223˙947.00
12	UNIVERSITE PARIS DESCARTES UNIVERSITE PARIS DESCARTES Organization address address: RUE DE L ECOLE DE MEDECINE 12 city: PARIS CEDEX 06 postcode: 75270 website: www.univ-paris5.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 06)	participant	0.00
13	BASF SE BASF SE Organization address address: CARL BOSCH STRASSE 38 city: LUDWIGSHAFEN AM RHEIN postcode: 67063 website: www.basf.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUDWIGSHAFEN AM RHEIN)	partner	0.00
14	BLACKTRACE HOLDINGS LIMITED BLACKTRACE HOLDINGS LIMITED Organization address address: JARMAN WAY 27 city: ROYSTON postcode: SG8 5HW website: www.blacktrace.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ROYSTON)	partner	0.00
15	DROP-TECH LTD DROP-TECH LTD Organization address address: Canterbury Street, Canterbury Court 91 city: Cambridge postcode: CB4 3QU website: http://www.drop-tech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Cambridge)	partner	0.00
16	ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS Organization address address: RUE VAUQUELIN 10 city: PARIS postcode: 75231 website: www.espci-paristech.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	partner	0.00
17	MICROFLUIDIC CHIPSHOP GMBH MICROFLUIDIC CHIPSHOP GMBH Organization address address: STOCKHOLMER STRASSE 20 city: JENA postcode: 7747 website: www.microfluidic-ChipShop.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (JENA)	partner	0.00
18	PRESIDENT AND FELLOWS OF HARVARD COLLEGE PRESIDENT AND FELLOWS OF HARVARD COLLEGE Organization address address: MASSACHUSETTS AVENUE 1350 city: CAMBRIDGE postcode: 2138 website: www.bidmc.harvard.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (CAMBRIDGE)	partner	0.00
19	SPHERE FLUIDICS LIMITED SPHERE FLUIDICS LIMITED Organization address address: THE JONAS WEBB BUILDING, BABRAHAM RESEARCH CAMPUS city: BABRAHAM CAMBRIDGE postcode: CB22 3AT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BABRAHAM CAMBRIDGE)	partner	0.00
20	THE UNIVERSITY OF HONG KONG THE UNIVERSITY OF HONG KONG Organization address address: Pokfulam Road city: Pokfulam postcode: n.a. website: www.hku.hk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HK (Pokfulam)	partner	0.00

Map

Project objective

Natural evolution is a powerful process that has given rise to the functionally diverse set of proteins present in all living systems. Repetitive rounds of mutation, selection and amplification have optimised nature’s catalysts, the enzymes, to perform an enormous range of different reactions. However, natural evolution has driven the optimisation of enzymes subjected to living functions of microorganisms, according to ill-defined and fluctuating external conditions and is not suitable for industrial processes since it lacks of control of selection pressure. In EVOdrops, we will use directed evolution to overcome these limitations. It is a synthetic, man-made approach of evolution, aiming at improving living systems based on predefined needs, controlling the external selection pressure. While natural evolution took billions of years to optimise macromolecules, directed evolution – to be efficient in an industrial process – requires both the generation of genetic diversity and ultra-high throughput screening capabilities to recover the variants of interest. We will develop and optimise these tools using the ground-breaking potential of droplet-based microfluidics for high-throughput experimentation and the fine control of gene library construction. EVOdrops, a European training network, will bring together the leading research scientists, laboratories and industries in Europe with outstanding expertise in protein engineering and microfluidics and 13 early stage researchers. We will offer an extensive multi- and interdisciplinary training to ensure that they can solve these urgent and unmet challenges in biotechnology and biomedicine. We will use a multidisciplinary approach combining soft matter, microfluidics and chemical biology to design solutions for the selection of new enzymes of industrial and therapeutic interest. In the future, our approaches can be generalised to challenges involving high-throughput miniaturised biochemical or cell-based assays.

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The information about "EVODROPS" are provided by the European Opendata Portal: CORDIS opendata.