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EVOdrops SIGNED

directed EVOlution in DROPS

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EVOdrops project word cloud

Explore the words cloud of the EVOdrops project. It provides you a very rough idea of what is the project "EVOdrops" about.

functions    biotechnology    mutation    repetitive    scientists    13    expertise    rounds    droplet    extensive    breaking    natural    outstanding    ground    nature    perform    ultra    synthetic    optimise    biochemical    laboratories    diversity    biomedicine    chemical    ill    catalysts    microorganisms    unmet    efficient    tools    multidisciplinary    overcome    fluctuating    variants    powerful    construction    screening    assays    cell    interdisciplinary    evolution    optimisation    fine    subjected    engineering    genetic    combining    evodrops    enzymes    living    enormous    industries    gene    network    pressure    industrial    functionally    recover    soft    experimentation    diverse    made    lacks    man    proteins    generalised    suitable    predefined    solutions    throughput    limitations    therapeutic    directed    amplification    urgent    protein    billions    of    took    generation    miniaturised    reactions    stage    training    external    microfluidics    macromolecules    library    biology   

Project "EVOdrops" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 3˙452˙422 €
 EC max contribution 3˙452˙422 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 606˙345.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 527˙543.00
3    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 303˙172.00
4    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 281˙276.00
5    BIOMILLENIA FR (ROMAINVILLE) participant 274˙802.00
6    UNIVERSITE DE PARIS FR (PARIS) participant 274˙802.00
7    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) participant 256˙320.00
8    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 252˙788.00
9    INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK PL (WARSZAWA) participant 227˙478.00
10    UAB THERMO FISHER SCIENTIFIC BALTICS LT (VILNIUS) participant 223˙947.00
11    VILNIAUS UNIVERSITETAS LT (VILNIUS) participant 223˙947.00
12    UNIVERSITE PARIS DESCARTES FR (PARIS CEDEX 06) participant 0.00
13    BASF SE DE (LUDWIGSHAFEN AM RHEIN) partner 0.00
14    BLACKTRACE HOLDINGS LIMITED UK (ROYSTON) partner 0.00
15    DROP-TECH LTD UK (Cambridge) partner 0.00
16    ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS FR (PARIS) partner 0.00
17    MICROFLUIDIC CHIPSHOP GMBH DE (JENA) partner 0.00
18    PRESIDENT AND FELLOWS OF HARVARD COLLEGE US (CAMBRIDGE) partner 0.00
19    SPHERE FLUIDICS LIMITED UK (BABRAHAM CAMBRIDGE) partner 0.00
20    THE UNIVERSITY OF HONG KONG HK (Pokfulam) partner 0.00

Map

 Project objective

Natural evolution is a powerful process that has given rise to the functionally diverse set of proteins present in all living systems. Repetitive rounds of mutation, selection and amplification have optimised nature’s catalysts, the enzymes, to perform an enormous range of different reactions. However, natural evolution has driven the optimisation of enzymes subjected to living functions of microorganisms, according to ill-defined and fluctuating external conditions and is not suitable for industrial processes since it lacks of control of selection pressure. In EVOdrops, we will use directed evolution to overcome these limitations. It is a synthetic, man-made approach of evolution, aiming at improving living systems based on predefined needs, controlling the external selection pressure. While natural evolution took billions of years to optimise macromolecules, directed evolution – to be efficient in an industrial process – requires both the generation of genetic diversity and ultra-high throughput screening capabilities to recover the variants of interest. We will develop and optimise these tools using the ground-breaking potential of droplet-based microfluidics for high-throughput experimentation and the fine control of gene library construction. EVOdrops, a European training network, will bring together the leading research scientists, laboratories and industries in Europe with outstanding expertise in protein engineering and microfluidics and 13 early stage researchers. We will offer an extensive multi- and interdisciplinary training to ensure that they can solve these urgent and unmet challenges in biotechnology and biomedicine. We will use a multidisciplinary approach combining soft matter, microfluidics and chemical biology to design solutions for the selection of new enzymes of industrial and therapeutic interest. In the future, our approaches can be generalised to challenges involving high-throughput miniaturised biochemical or cell-based assays.

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The information about "EVODROPS" are provided by the European Opendata Portal: CORDIS opendata.

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