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EuroNeurotrophin SIGNED

A European training network for the discovery of neurotrophins small molecule mimetics as candidate therapeutic agents for neurodegeneration and neuroinflammation

Total Cost €

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EC-Contrib. €

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Partnership

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EuroNeurotrophin project word cloud

Explore the words cloud of the EuroNeurotrophin project. It provides you a very rough idea of what is the project "EuroNeurotrophin" about.

mnd translate small profiles collaborative therapeutic cure therapies 12 forth discovery consists candidate training doctoral molecules first limitation successful als nd seminal molecule possess diseases comprehend clinical ad render prohibitive companies societies beneficiaries fail neuroprotection skills neurodegenerative motivated probes tissue demonstrated neurons tackle point market treatments pathogenesis complementary stage poor translation single accelerate survival function actions stability penetration collectively specialists conduct designed collaborations biological skilled of enriched pharmacokinetic interrogate neurotrophins ms builds patented pd mimetics expertise shown academic euroneurotrophin emphasise exists drugs private worldwide idea molecular 14 nhrf neurogenesis groups drug preclinical deep network neurotrophin

Project "EuroNeurotrophin" data sheet

The following table provides information about the project.

Coordinator	ETHNIKO IDRYMA EREVNON Organization address address: VAS KONSTANTINOU 48 city: ATHINA postcode: 11635 website: www.eie.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Total cost	3˙555˙758 €
EC max contribution	3˙555˙758 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2017
Funding Scheme	MSCA-ITN-ETN
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ETHNIKO IDRYMA EREVNON ETHNIKO IDRYMA EREVNON Organization address address: VAS KONSTANTINOU 48 city: ATHINA postcode: 11635 website: www.eie.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	coordinator	484˙773.00
2	AvantiCell Science Ltd AvantiCell Science Ltd Organization address address: GIBBSYARD BUILDING city: AYR postcode: KA6 5HW website: www.avanticell.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (AYR)	participant	546˙575.00
3	HITS GGMBH HITS GGMBH Organization address address: SCHLOSS WOLFSBRUNNENWEG 35 city: HEIDELBERG postcode: 69118 website: http://www.h-its.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	498˙432.00
4	IDRYMA TECHNOLOGIAS KAI EREVNAS IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	participant	484˙773.00
5	THE UNIVERSITY OF SHEFFIELD THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	participant	273˙287.00
6	UNIVERSITE DE CAEN NORMANDIE UNIVERSITE DE CAEN NORMANDIE Organization address address: ESPLANADE DE LA PAIX city: CAEN CEDEX 5 postcode: 14032 website: www.unicaen.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (CAEN CEDEX 5)	participant	262˙875.00
7	UNIVERSITA DEGLI STUDI DI SIENA UNIVERSITA DEGLI STUDI DI SIENA Organization address address: VIA BANCHI DI SOTTO 55 city: SIENA postcode: 53100 website: www.unisi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	participant	258˙061.00
8	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	255˙374.00
9	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	249˙216.00
10	ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Organization address address: 6 CHRISTOU LADA STR city: ATHINA postcode: 10561 website: www.elke.uoa.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	242˙386.00
11	ACCELOPMENT AG ACCELOPMENT AG Organization address address: SEEFELDSTRASSE 198 city: ZUERICH postcode: 8008 website: www.accelopment.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	partner	0.00
12	Innovative Technologies in Biological Systems Innovative Technologies in Biological Systems Organization address address: PARQUE TECNOLOGICO DE BIZKAIA 502-1 city: Derio postcode: 48160 website: www.innoprot.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Derio)	partner	0.00
13	Novartis (ΕλλÎ¬ς) Α.Ε.Β.Ε. Novartis (ΕλλÎ¬ς) Α.Ε.Β.Ε. Organization address address: National Rd. No 1 12th Km city: Metamorphosis postcode: 14451 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (Metamorphosis)	partner	0.00
14	PANEPISTIMIO KRITIS PANEPISTIMIO KRITIS Organization address address: UNIVERSITY CAMPUS GALLOS city: RETHIMNO postcode: 74100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (RETHIMNO)	partner	0.00
15	Peakdale Molecular Limited Peakdale Molecular Limited Organization address address: Sheffield Road city: Chapel-en-le-Frith postcode: SK23 0PG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Chapel-en-le-Frith)	partner	0.00
16	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	partner	0.00
17	Ventac A/S Ventac A/S Organization address address: Agern Alle 24 city: Hoersholm postcode: 2970 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (Hoersholm)	partner	0.00

Map

Project objective

Neurodegenerative diseases (ND) like AD, PD, MS and ALS/MND are on the rise in developed societies worldwide. Currently, there exists no cure for any ND, and most of the available drugs fail to tackle ND pathogenesis. Preclinical studies point to the therapeutic potential of neurotrophins, which have been shown to control a number of aspects of survival, development and function of neurons. However, the poor pharmacokinetic properties of neurotrophins render their use as drugs prohibitive. The key idea behind this project is to address this limitation by developing novel small molecule, neurotrophin mimetics with favourable profiles of stability, tissue penetration and targeted biological actions. We are motivated by seminal (patented) results of beneficiaries NHRF and FORTH, who recently demonstrated promising effects of small neurotrophin mimetics in neuroprotection and neurogenesis. EuroNeurotrophin will be the first European consortium to study small molecule neurotrophin mimetics in depth, use them as molecular probes to interrogate neurotrophins, and emphasise their clinical translation. This approach requires highly skilled researchers that have a deep understanding of neurotrophins, comprehend all steps of drug discovery and development for ND, and possess the necessary skills to translate results into novel therapies. The network has been designed to address the need for the development of new ND treatments through the collaborative training of 14 early-stage researchers. It builds on previous successful collaborations enriched with key specialists, and consists of 12 leading European research groups and 6 private companies of complementary expertise covering all steps of drug discovery and development. Collectively we will (a) conduct a unique training programme that could not be achieved by doctoral training within a single academic institution and (b) accelerate the translation of identified drug candidate molecules into the market.

Publications

List of publications.
year	authors and title	journal	last update
2020	Athanasios Ziogas, Tomoki Maekawa, Johannes R. Wiessner, Thi Trang Le, David Sprott, Maria Troullinaki, Ales Neuwirth, Vasiliki Anastasopoulou, Sylvia Grossklaus, Kyoung-Jin Chung, Markus Sperandio, Triantafyllos Chavakis, George Hajishengallis, Vasileia Ismini Alexaki DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1 published pages: 1214-1224, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1900746	The Journal of Immunology 204/5	2020-03-11
2019	Canelif Yilmaz, Kanelina Karali, Georgia Fodelianaki, Achille Gravanis, Triantafyllos Chavakis, Ioannis Charalampopoulos, Vasileia Ismini Alexaki Neurosteroids as regulators of neuroinflammation published pages: 100788, ISSN: 0091-3022, DOI: 10.1016/j.yfrne.2019.100788	Frontiers in Neuroendocrinology 55	2020-03-11

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