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SAFER SIGNED

Selective Agonists For Serotonin Receptors

Total Cost €

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EC-Contrib. €

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Partnership

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 SAFER project word cloud

Explore the words cloud of the SAFER project. It provides you a very rough idea of what is the project "SAFER" about.

resource    structures    services    molecular    location    move    complementary    crystals    train    fundamental    protein    seek    first    data    giving    community    models    gain    treatments    advantage    biased    job    public    subsequently    ht2a    therapeutic    world    transferrable    synchrotron    demand    ultimate    cns    receptor    drugs    students    construct    arming    guide    interdisciplinary    experiments    university    lund    translate    selectivity    scientific    gpcrdb    obtain    commercial    serotonin    business    computational    max    smes    worldwide    complementarity    active    phd    pharmacology    biological    mastered    hallucinogens    expertise    ligands    mechanistic    pharmaceuticals    industry    crystallography    understand    few    innovation    receptors    opportune    society    crystallographic    sweden    primary    skills    intersectoral    insights    cross    databases    building    safer    generate    groups    market    ample    signalling    crystal    mechanisms    disorders    coupled    basic    sustainability    esrs    interpret    timing    competitive   

Project "SAFER" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.safer-itn.eu/
 Total cost 1˙286˙630 €
 EC max contribution 1˙286˙630 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-EID
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 290˙081.00
2    SAROMICS BIOSTRUCTURES AB SE (Lund) participant 512˙670.00
3    ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE UA (KYIV) participant 483˙878.00

Map

 Project objective

SAFER will train 5 ESRs, PhD students, to obtain ample scientific, business and transferrable skills, arming them with the expertise to translate knowledge into products and services with importance for European industry and society. All ESRs will first train together at one university to develop complementary skills and basic research data; and subsequently move to two SMEs for applied and commercial research.

The ultimate scientific goal for the SAFER program is to gain molecular understanding and improve selectivity in treatments of CNS-related disorders. This will be done through an interdisciplinary and intersectoral approach, building on a strong complementarity between partners, with a particular focus on the serotonin 5-HT2A receptor – the primary target for many pharmaceuticals and hallucinogens. SAFER will generate and cross-interpret pharmacology and crystallographic data, and construct computational mechanistic models and databases that can explain and guide its experiments. Thus, SAFER will gain new insights into molecular mechanisms that are fundamental to understand the biological and therapeutic effects, and to develop safer drugs. SAFER ESRs will be highly competitive on the job market and much in demand. In particular, crystallography and biased signalling pharmacology of G protein-coupled receptors (e.g. 5-HT2A) are new and highly active research fields, today mastered by only a very few research groups worldwide. The timing and location of SAFER are particularly opportune, taking advantage of the new synchrotron MAX IV in Lund, Sweden, which is world leading for the study of challenging crystals. SAFER will seek to exploit innovation opportunities from novel molecular mechanisms, ligands, and crystal structures. The results will be integrated into a public community resource, GPCRdb, giving a unique potential to achieve community impact and long-term sustainability.

 Deliverables

List of deliverables.
2nd report on dissemination activities Documents, reports 2019-10-03 18:10:31
SAFER web site Websites, patent fillings, videos etc. 2019-07-24 18:15:34
1st report on dissemination activities Documents, reports 2019-07-24 18:15:34

Take a look to the deliverables list in detail:  detailed list of SAFER deliverables.

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The information about "SAFER" are provided by the European Opendata Portal: CORDIS opendata.

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