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SAFER SIGNED

Selective Agonists For Serotonin Receptors

Total Cost €

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EC-Contrib. €

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Partnership

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 SAFER project word cloud

Explore the words cloud of the SAFER project. It provides you a very rough idea of what is the project "SAFER" about.

construct    gain    job    sweden    models    receptor    coupled    receptors    mastered    intersectoral    understand    experiments    giving    seek    first    esrs    competitive    community    disorders    market    ligands    therapeutic    hallucinogens    move    subsequently    interpret    few    innovation    pharmaceuticals    max    industry    sustainability    primary    biological    biased    ht2a    commercial    structures    crystallographic    computational    building    resource    pharmacology    protein    advantage    crystal    business    crystallography    drugs    groups    society    smes    data    services    insights    selectivity    timing    molecular    translate    active    train    interdisciplinary    crystals    mechanisms    complementary    public    databases    phd    signalling    obtain    mechanistic    cns    expertise    treatments    fundamental    basic    gpcrdb    generate    arming    ample    transferrable    demand    university    skills    students    opportune    safer    complementarity    world    serotonin    lund    guide    ultimate    worldwide    location    cross    synchrotron    scientific   

Project "SAFER" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.safer-itn.eu/
 Total cost 1˙286˙630 €
 EC max contribution 1˙286˙630 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-EID
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 290˙081.00
2    SAROMICS BIOSTRUCTURES AB SE (Lund) participant 512˙670.00
3    ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE UA (KYIV) participant 483˙878.00

Map

 Project objective

SAFER will train 5 ESRs, PhD students, to obtain ample scientific, business and transferrable skills, arming them with the expertise to translate knowledge into products and services with importance for European industry and society. All ESRs will first train together at one university to develop complementary skills and basic research data; and subsequently move to two SMEs for applied and commercial research.

The ultimate scientific goal for the SAFER program is to gain molecular understanding and improve selectivity in treatments of CNS-related disorders. This will be done through an interdisciplinary and intersectoral approach, building on a strong complementarity between partners, with a particular focus on the serotonin 5-HT2A receptor – the primary target for many pharmaceuticals and hallucinogens. SAFER will generate and cross-interpret pharmacology and crystallographic data, and construct computational mechanistic models and databases that can explain and guide its experiments. Thus, SAFER will gain new insights into molecular mechanisms that are fundamental to understand the biological and therapeutic effects, and to develop safer drugs. SAFER ESRs will be highly competitive on the job market and much in demand. In particular, crystallography and biased signalling pharmacology of G protein-coupled receptors (e.g. 5-HT2A) are new and highly active research fields, today mastered by only a very few research groups worldwide. The timing and location of SAFER are particularly opportune, taking advantage of the new synchrotron MAX IV in Lund, Sweden, which is world leading for the study of challenging crystals. SAFER will seek to exploit innovation opportunities from novel molecular mechanisms, ligands, and crystal structures. The results will be integrated into a public community resource, GPCRdb, giving a unique potential to achieve community impact and long-term sustainability.

 Deliverables

List of deliverables.
2nd report on dissemination activities Documents, reports 2019-10-03 18:10:31
SAFER web site Websites, patent fillings, videos etc. 2019-07-24 18:15:34
1st report on dissemination activities Documents, reports 2019-07-24 18:15:34

Take a look to the deliverables list in detail:  detailed list of SAFER deliverables.

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The information about "SAFER" are provided by the European Opendata Portal: CORDIS opendata.

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