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SAFER SIGNED

Selective Agonists For Serotonin Receptors

Total Cost €

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EC-Contrib. €

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Partnership

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 SAFER project word cloud

Explore the words cloud of the SAFER project. It provides you a very rough idea of what is the project "SAFER" about.

insights    building    models    computational    therapeutic    biased    seek    disorders    ligands    primary    structures    signalling    obtain    interdisciplinary    students    pharmaceuticals    interpret    location    crystallography    max    business    giving    translate    market    ample    scientific    selectivity    expertise    crystals    guide    advantage    society    phd    opportune    train    move    arming    community    molecular    ht2a    university    ultimate    first    fundamental    timing    demand    groups    competitive    coupled    transferrable    gain    construct    gpcrdb    drugs    synchrotron    serotonin    resource    skills    crystallographic    data    receptors    safer    job    few    complementarity    esrs    industry    subsequently    intersectoral    experiments    databases    sustainability    cross    active    mastered    basic    pharmacology    protein    mechanistic    services    understand    mechanisms    receptor    smes    worldwide    world    complementary    sweden    hallucinogens    commercial    innovation    biological    cns    crystal    public    lund    generate    treatments   

Project "SAFER" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.safer-itn.eu/
 Total cost 1˙286˙630 €
 EC max contribution 1˙286˙630 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-EID
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 290˙081.00
2    SAROMICS BIOSTRUCTURES AB SE (Lund) participant 512˙670.00
3    ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE UA (KYIV) participant 483˙878.00

Map

 Project objective

SAFER will train 5 ESRs, PhD students, to obtain ample scientific, business and transferrable skills, arming them with the expertise to translate knowledge into products and services with importance for European industry and society. All ESRs will first train together at one university to develop complementary skills and basic research data; and subsequently move to two SMEs for applied and commercial research.

The ultimate scientific goal for the SAFER program is to gain molecular understanding and improve selectivity in treatments of CNS-related disorders. This will be done through an interdisciplinary and intersectoral approach, building on a strong complementarity between partners, with a particular focus on the serotonin 5-HT2A receptor – the primary target for many pharmaceuticals and hallucinogens. SAFER will generate and cross-interpret pharmacology and crystallographic data, and construct computational mechanistic models and databases that can explain and guide its experiments. Thus, SAFER will gain new insights into molecular mechanisms that are fundamental to understand the biological and therapeutic effects, and to develop safer drugs. SAFER ESRs will be highly competitive on the job market and much in demand. In particular, crystallography and biased signalling pharmacology of G protein-coupled receptors (e.g. 5-HT2A) are new and highly active research fields, today mastered by only a very few research groups worldwide. The timing and location of SAFER are particularly opportune, taking advantage of the new synchrotron MAX IV in Lund, Sweden, which is world leading for the study of challenging crystals. SAFER will seek to exploit innovation opportunities from novel molecular mechanisms, ligands, and crystal structures. The results will be integrated into a public community resource, GPCRdb, giving a unique potential to achieve community impact and long-term sustainability.

 Deliverables

List of deliverables.
2nd report on dissemination activities Documents, reports 2019-10-03 18:10:31
SAFER web site Websites, patent fillings, videos etc. 2019-07-24 18:15:34
1st report on dissemination activities Documents, reports 2019-07-24 18:15:34

Take a look to the deliverables list in detail:  detailed list of SAFER deliverables.

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The information about "SAFER" are provided by the European Opendata Portal: CORDIS opendata.

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