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EVICARE SIGNED

Extracellular Vesicle-Inspired CArdiac Repair

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EVICARE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙997˙297 €
 EC max contribution 1˙997˙297 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 1˙997˙297.00

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 Project objective

More than 3.5 million people are newly diagnosed with heart failure every year in Europe with a long-term prognosis of 50% mortality within 4 years. There is a major need for more innovative, regenerative therapies that have the potential to change the course of disease. My hypothesis is that we can recondition heart failure by stimulating cardiac repair with extracellular vesicles that are derived from progenitor cells. In my laboratory, extracellular released vesicles containing a cocktail of stimulating factors, are amongst the most potent vectors for cardiac repair. To achieve a sustainable and long-term therapeutic effect of these vesicles and enhance cardiac function by stimulating myocardial repair, we will 1) improve local cardiac delivery of progenitor cell-derived extracellular vesicles, 2) understand the mechanism of action of extracellular vesicles, and 3) stimulate extracellular vesicles release and/or production by progenitor cells. These questions form the rationale for the current proposal in which we will co-inject extracellular vesicles and slow-release biomaterials into the damaged myocardium. By subsequent genetic tracing, we will determine fate mapping of injected vesicles in vivo, and perform further mechanistic understanding in in vitro culture models of targeted and identified myocardial cell types. Moreover, we will upscale the vesicles production by progenitor cells further via bioreactor culturing and medium-throughput screening on factors that stimulate vesicles release. The use of stem cell-derived extracellular vesicles to stimulate cardiac repair will potentially allow for an off-the shelf approach, including mechanistic understanding and future clinical use. Additionally, since these vesicles act as a natural carrier system outperforming current artificial drug delivery, we might understand and mimic their characteristics to enhance local (RNA-based) drug delivery systems for cardiovascular application.

 Publications

year authors and title journal last update
List of publications.
2019 Marijn M.C. Peters, Timion A. Meijs, Wouter Gathier, Pieter A.M. Doevendans, Joost P.G. Sluijter, Steven A.J. Chamuleau, Klaus Neef
Follistatin-like 1 in Cardiovascular Disease and Inflammation
published pages: , ISSN: 1389-5575, DOI: 10.2174/1389557519666190312161551
Mini-Reviews in Medicinal Chemistry 19 2019-10-08
2017 Emma A. Mol, Marie-José Goumans, Pieter A. Doevendans, Joost P.G. Sluijter, Pieter Vader
Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation
published pages: 2061-2065, ISSN: 1549-9634, DOI: 10.1016/j.nano.2017.03.011
Nanomedicine: Nanotechnology, Biology and Medicine 13/6 2019-10-08
2019 Rudolf A. de Boer, Gilles De Keulenaer, Johann Bauersachs, Dirk Brutsaert, John G. Cleland, Javier Diez, Xiao‐Jun Du, Paul Ford, Frank R. Heinzel, Kenneth E. Lipson, Theresa McDonagh, Natalia Lopez‐Andres, Ida G. Lunde, Alexander R. Lyon, Piero Pollesello, Sanjay K. Prasad, Carlo G. Tocchetti, Manuel Mayr, Joost P.G. Sluijter, Thomas Thum, Carsten Tschöpe, Faiez Zannad, Wolfram‐Hubertus Zim
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology
published pages: 272-285, ISSN: 1388-9842, DOI: 10.1002/ejhf.1406
European Journal of Heart Failure 21/3 2019-10-08
2018 Alain van Mil, Geerthe Margriet Balk, Klaus Neef, Jan Willem Buikema, Folkert W Asselbergs, Sean M Wu, Pieter A Doevendans, Joost P G Sluijter
Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential
published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvy208
Cardiovascular Research 2019-10-08
2019 Janita A. Maring, Kirsten Lodder, Emma Mol, Vera Verhage, Karien C. Wiesmeijer, Calinda K. E. Dingenouts, Asja T. Moerkamp, Janine C. Deddens, Pieter Vader, Anke M. Smits, Joost P. G. Sluijter, Marie-José Goumans
Cardiac Progenitor Cell–Derived Extracellular Vesicles Reduce Infarct Size and Associate with Increased Cardiovascular Cell Proliferation
published pages: 5-17, ISSN: 1937-5387, DOI: 10.1007/s12265-018-9842-9
Journal of Cardiovascular Translational Research 12/1 2019-10-08
2019 Sandra Crnko, Bastiaan C. Du Pré, Joost P. G. Sluijter, Linda W. Van Laake
Circadian rhythms and the molecular clock in cardiovascular biology and disease
published pages: , ISSN: 1759-5002, DOI: 10.1038/s41569-019-0167-4
Nature Reviews Cardiology 2019-10-08
2019 Rosalinda Madonna, Linda W Van Laake, Hans Erik Botker, Sean M Davidson, Raffaele De Caterina, Felix B Engel, Thomas Eschenhagen, Francesco Fernandez-Aviles, Derek J Hausenloy, Jean-Sebastien Hulot, Sandrine Lecour, Jonathan Leor, Philippe Menasché, Maurizio Pesce, Cinzia Perrino, Fabrice Prunier, Sophie Van Linthout, Kirsti Ytrehus, Wolfram-Hubertus Zimmermann, Peter Ferdinandy, Joost P G Sluijt
ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure
published pages: 488-500, ISSN: 0008-6363, DOI: 10.1093/cvr/cvz010
Cardiovascular Research 115/3 2019-10-08
2018 F. van den Akker, K.R. Vrijsen, J.C. Deddens, J.W. Buikema, M. Mokry, L.W. van Laake, P.A. Doevendans, J.P.G. Sluijter
Suppression of T cells by mesenchymal and cardiac progenitor cells is partly mediated via extracellular vesicles
published pages: e00642, ISSN: 2405-8440, DOI: 10.1016/j.heliyon.2018.e00642
Heliyon 4/6 2019-06-12
2018 Aisha Gohar, Dominique P.V. de Kleijn, Arno W. Hoes, Frans H. Rutten, Denise Hilfiker-Kleiner, Péter Ferdinandy, Joost P.G. Sluijter, Hester M. den Ruijter
Vascular extracellular vesicles in comorbidities of heart failure with preserved ejection fraction in men and women: The hidden players. A mini review
published pages: , ISSN: 1537-1891, DOI: 10.1016/j.vph.2018.05.006
Vascular Pharmacology 2019-06-12
2017 Joost Petrus Gerardus Sluijter, Sean Michael Davidson, Chantal M Boulanger, Edit Iren Buzás, Dominique Paschalis Victor de Kleijn, Felix Benedikt Engel, Zoltán Giricz, Derek J Hausenloy, Raj Kishore, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Cinzia Perrino, Fabrice Prunier, Susmita Sahoo, Ray Michel Schiffelers, Rainer Schulz, Linda Wilhelmina Van Laake, Kirsti Ytrehus, Péter Ferdinandy
Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology
published pages: 19-34, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx211
Cardiovascular Research 114/1 2019-06-12
2017 E. A. Mol, M. J. Goumans, J. P. G. Sluijter
Cardiac Progenitor-Cell Derived Exosomes as Cell-Free Therapeutic for Cardiac Repair
published pages: 207-219, ISSN: , DOI: 10.1007/978-981-10-4397-0_14
2019-06-12

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