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BioMeTRe SIGNED

Biophysical mechanisms of long-range transcriptional regulation

Total Cost €

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EC-Contrib. €

0

Partnership

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 BioMeTRe project word cloud

Explore the words cloud of the BioMeTRe project. It provides you a very rough idea of what is the project "BioMeTRe" about.

description    associating    cognate    paradigms    outputs    perturbations    layer    structure    entirely    regulation    physical    engineering    fiber    chromosomes    sub    mechanisms    away    enhancers    cell    testable    topologically    tuned    mechanistic    link    enzymatic    structures    genomic    kilobases    predictions    principles    partitioned    cells    located    smaller    domains    unknown    epigenetics    transcriptional    tads    regulatory    proximity    quantitative    single    distal    levels    dimensional    tens    data    promoters    capture    totally    conformation    megabase    fine    biology    chromosome    experiments    genes    tad    chromosomal    mutual    revealed    restrict    mammals    details    interactions    molecular    transcription    relate    preferential    chromatin    hundreds    population    showed    underlying    operation    functional    models    linked    translate    boundaries    enhancer    confounding    gene    relies    formulate    communication    promoter    modeling    experimental    explore    biophysical    sequences    cis    time    vivo    interpret    genetic   

Project "BioMeTRe" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 1˙500˙000.00

Map

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 Project objective

In mammals, transcriptional control of many genes relies on cis-regulatory elements such as enhancers, which are often located tens to hundreds of kilobases away from their cognate promoters. Functional interactions between distal regulatory elements and target promoters require mutual physical proximity, which is linked to the three-dimensional structure of the chromatin fiber. Chromosome conformation capture studies revealed that chromosomes are partitioned into Topologically Associating Domains (TADs), sub-megabase domains of preferential physical interactions of the chromatin fiber. Genetic evidence showed that TAD boundaries restrict the genomic range of enhancer-promoter communication, and that interactions between regulatory sequences within TADs are further fine-tuned by smaller-scale structures. However, the mechanistic details of how physical interactions translate into transcriptional outputs are totally unknown. Here we propose to explore the biophysical mechanisms that link chromosome conformation and long-range transcriptional regulation using molecular biology, genetic engineering, single-cell experiments and physical modeling. We will measure chromosomal interactions in single cells and in time using a novel method that relies on an enzymatic process in vivo. Genetic engineering will be used to establish a cell system that allows quantitative measurement of how enhancer-promoter interactions relate to transcription at the population and single-cell levels, and to test the effects of perturbations without confounding effects. Finally, we will develop physical models of promoter operation in the presence of distal enhancers, which will be used to interpret the experimental data and formulate new testable predictions. With this integrated approach we aim at providing an entirely new layer of description of the general principles underlying transcriptional control, which could establish new paradigms for research in epigenetics and gene regulation.

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The information about "BIOMETRE" are provided by the European Opendata Portal: CORDIS opendata.

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