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CURE SIGNED

Constructing a ‘Eubiosis Reinstatement Therapy’ for Asthma

Total Cost €

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EC-Contrib. €

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Partnership

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 CURE project word cloud

Explore the words cloud of the CURE project. It provides you a very rough idea of what is the project "CURE" about.

tool    interactions    therapy    vitro    calls    relatively    reaching    innovation    deviations    susceptibility    untangling    huge    strategy    patients    disease    grossly    indicate    tuned    microbiome    humans    allergy    dysbiotic    bacteriophages    viruses    inflammatory    appropriate    appearing    world    infection    deaths    close    western    upper    bacterial    predict    treatments    initiation    attacks    dysregulation    predictive    abundance    candidates    cure    efforts    countries    expression    atopic    model    immune    reveal    clinical    imbalanced    interventions    notwithstanding    unexplored    feasible    fine    eubiosis    asthma    microbe    health    interface    rebalancing    imposes    presentation    respiratory    follow    unacceptably    treatment    generally    preparations    reinstating    symptom    airway    suboptimal    data    never    levels    pathophysiology    dysbiosis    naturally    phages    asthmatic    validated    infections    adding    host    despite    disruptive    infect    burden    hospitalisations    ecology    characteristically    pandemic    persistence    mixtures    acute    airways    virus    phage    populations   

Project "CURE" data sheet

The following table provides information about the project.

Coordinator
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON 

Organization address
address: 6 CHRISTOU LADA STR
city: ATHINA
postcode: 10561
website: www.elke.uoa.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website https://www.cureasthma.eu
 Total cost 2˙971˙750 €
 EC max contribution 2˙971˙750 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON EL (ATHINA) coordinator 353˙750.00
2    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 1˙128˙000.00
3    SCHWEIZERISCHES FORSCHUNGSINSTITUT FUER HOCHGEBIRGSKLIMA UND MEDIZIN IN DAVOS CH (DAVOS PLATZ) participant 287˙500.00
4    UNIVERSYTET MEDYCZNY W LODZI. PL (LODZ) participant 232˙500.00
5    GIORGI ELIAVA INSTITUTE OF BACTERIOPHAGY, MICROBIOLOGY AND VIROLOGY GE (TBILISI) participant 222˙500.00
6    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) participant 222˙500.00
7    UMEA UNIVERSITET SE (UMEA) participant 217˙500.00
8    MARIOS LYMARAKIS KAI SIA EE EL (GERAKAS ATTIKI) participant 135˙000.00
9    EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING BE (Brussels) participant 112˙500.00
10    ELIAVA BIO PREPARATIONS LTD GE (TBILISI) participant 60˙000.00

Map

 Project objective

The asthma pandemic imposes a huge burden on patients and health systems in both developed and developing countries. Notwithstanding major efforts in untangling its pathophysiology, we are not even close to reaching a cure. Despite available treatments, symptom control is generally suboptimal and hospitalisations and deaths remain at unacceptably high levels. This calls for disruptive innovation towards a long-term treatment strategy. Asthma is an inflammatory condition associated with immune deviations, most often atopic allergy. However, a key characteristic of asthma that remains relatively unexplored is susceptibility to infection. Most acute asthma attacks follow upper respiratory infections; infections are also associated with asthma initiation and persistence. Recent studies reveal that the respiratory microbiome is characteristically imbalanced (dysbiotic) in asthma. Our own data indicate that a feature of dysbiosis in asthma is reduced abundance of bacteriophages (phages). These bacterial viruses infect and are able to naturally control bacterial populations. Phage therapy has been grossly neglected in the western world and is currently just appearing as a novel tool against infection. However, it has never been used for rebalancing dysbiosis in humans. We propose that reinstating eubiosis within the asthmatic airway through phage therapy is feasible and will be able to control the immune dysregulation and clinical presentation of the disease. To achieve this, we must be able to predict the effects of adding phage mixtures to the complex ecology of the airways and design appropriate interventions. In CURE, we will develop a predictive model using information from virus-bacterial interactions, host responses and clinical disease expression, validated and fine-tuned using an in-vitro host-microbe-phage interface system. The project will develop phage preparations as candidates for clinical testing in asthma

 Deliverables

List of deliverables.
Website and logo Websites, patent fillings, videos etc. 2019-05-31 10:20:03
Variability in space & time Documents, reports 2019-05-31 10:20:01
Data Management Plan Documents, reports 2019-05-31 10:20:04

Take a look to the deliverables list in detail:  detailed list of CURE deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Evangelos Andreakos, Ivan Zanoni, Ioanna E Galani
Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control
published pages: 67-75, ISSN: 0952-7915, DOI: 10.1016/j.coi.2018.10.007
Current Opinion in Immunology 56 2019-04-18

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The information about "CURE" are provided by the European Opendata Portal: CORDIS opendata.

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