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CURE SIGNED

Constructing a ‘Eubiosis Reinstatement Therapy’ for Asthma

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

CURE project word cloud

Explore the words cloud of the CURE project. It provides you a very rough idea of what is the project "CURE" about.

humans persistence disruptive microbiome allergy infect mixtures abundance upper calls treatment virus reinstating tool data infection respiratory adding appearing interventions cure infections western populations notwithstanding treatments immune countries disease dysbiosis expression airways airway burden relatively preparations eubiosis naturally asthmatic validated phage initiation levels inflammatory ecology never interface hospitalisations despite fine deaths generally acute follow model presentation strategy interactions tuned bacterial rebalancing reaching indicate unexplored dysregulation susceptibility atopic predictive phages bacteriophages vitro close symptom appropriate deviations suboptimal characteristically world imposes microbe dysbiotic pathophysiology host health huge untangling grossly predict reveal imbalanced clinical feasible candidates attacks unacceptably viruses asthma patients efforts pandemic therapy innovation

Project "CURE" data sheet

The following table provides information about the project.

Coordinator	ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Organization address address: 6 CHRISTOU LADA STR city: ATHINA postcode: 10561 website: www.elke.uoa.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Project website	https://www.cureasthma.eu
Total cost	2˙971˙750 €
EC max contribution	2˙971˙750 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Organization address address: 6 CHRISTOU LADA STR city: ATHINA postcode: 10561 website: www.elke.uoa.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	coordinator	353˙750.00
2	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	1˙128˙000.00
3	SCHWEIZERISCHES FORSCHUNGSINSTITUT FUER HOCHGEBIRGSKLIMA UND MEDIZIN IN DAVOS SCHWEIZERISCHES FORSCHUNGSINSTITUT FUER HOCHGEBIRGSKLIMA UND MEDIZIN IN DAVOS Organization address address: PROMENADE 35 city: DAVOS PLATZ postcode: 7270 website: www.sfi-davos.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (DAVOS PLATZ)	participant	287˙500.00
4	UNIVERSYTET MEDYCZNY W LODZI. UNIVERSYTET MEDYCZNY W LODZI. Organization address address: Al. Kosciuszki, 4 city: LODZ postcode: 90419 website: www.umed.lodz.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (LODZ)	participant	232˙500.00
5	GIORGI ELIAVA INSTITUTE OF BACTERIOPHAGY, MICROBIOLOGY AND VIROLOGY GIORGI ELIAVA INSTITUTE OF BACTERIOPHAGY, MICROBIOLOGY AND VIROLOGY Organization address address: GOTUA STREET 3 city: TBILISI postcode: 160 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	GE (TBILISI)	participant	222˙500.00
6	IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Organization address address: SORANOU EFESIOU 4 city: ATHINA postcode: 115 27 website: www.bioacademy.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	222˙500.00
7	UMEA UNIVERSITET UMEA UNIVERSITET Organization address address: UNIVERSITETOMRADET city: UMEA postcode: 901 87 website: www.umu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UMEA)	participant	217˙500.00
8	MARIOS LYMARAKIS KAI SIA EE MARIOS LYMARAKIS KAI SIA EE Organization address address: ETHNIKIS ANTISTASEOS 132 city: GERAKAS ATTIKI postcode: 15344 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (GERAKAS ATTIKI)	participant	135˙000.00
9	EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING Organization address address: rue du Congrès 35 city: Brussels postcode: 1000 website: http://www.efanet.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (Brussels)	participant	112˙500.00
10	ELIAVA BIO PREPARATIONS LTD ELIAVA BIO PREPARATIONS LTD Organization address address: GOTUA STREET 3 city: TBILISI postcode: 160 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	GE (TBILISI)	participant	60˙000.00

Map

Project objective

The asthma pandemic imposes a huge burden on patients and health systems in both developed and developing countries. Notwithstanding major efforts in untangling its pathophysiology, we are not even close to reaching a cure. Despite available treatments, symptom control is generally suboptimal and hospitalisations and deaths remain at unacceptably high levels. This calls for disruptive innovation towards a long-term treatment strategy. Asthma is an inflammatory condition associated with immune deviations, most often atopic allergy. However, a key characteristic of asthma that remains relatively unexplored is susceptibility to infection. Most acute asthma attacks follow upper respiratory infections; infections are also associated with asthma initiation and persistence. Recent studies reveal that the respiratory microbiome is characteristically imbalanced (dysbiotic) in asthma. Our own data indicate that a feature of dysbiosis in asthma is reduced abundance of bacteriophages (phages). These bacterial viruses infect and are able to naturally control bacterial populations. Phage therapy has been grossly neglected in the western world and is currently just appearing as a novel tool against infection. However, it has never been used for rebalancing dysbiosis in humans. We propose that reinstating eubiosis within the asthmatic airway through phage therapy is feasible and will be able to control the immune dysregulation and clinical presentation of the disease. To achieve this, we must be able to predict the effects of adding phage mixtures to the complex ecology of the airways and design appropriate interventions. In CURE, we will develop a predictive model using information from virus-bacterial interactions, host responses and clinical disease expression, validated and fine-tuned using an in-vitro host-microbe-phage interface system. The project will develop phage preparations as candidates for clinical testing in asthma

Deliverables

List of deliverables.
Website and logo	Websites, patent fillings, videos etc.	2019-05-31 10:20:03
Variability in space & time	Documents, reports	2019-05-31 10:20:01
Data Management Plan	Documents, reports	2019-05-31 10:20:04

Take a look to the deliverables list in detail: detailed list of CURE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Evangelos Andreakos, Ivan Zanoni, Ioanna E Galani Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control published pages: 67-75, ISSN: 0952-7915, DOI: 10.1016/j.coi.2018.10.007	Current Opinion in Immunology 56	2019-04-18

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The information about "CURE" are provided by the European Opendata Portal: CORDIS opendata.

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