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FarCatCH SIGNED

Innovative Strategies for Unprecedented Remote C-H bond Functionalization by Catalysis

Total Cost €

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EC-Contrib. €

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Partnership

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 FarCatCH project word cloud

Explore the words cloud of the FarCatCH project. It provides you a very rough idea of what is the project "FarCatCH" about.

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Project "FarCatCH" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.bessetgroup.cnrs.fr
 Total cost 1˙497˙996 €
 EC max contribution 1˙497˙996 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙497˙996.00

Map

 Project objective

Over the last years, the landscape of the organic chemistry has been reshaped with impressive advances made in the transition metal-catalyzed carbon-hydrogen (C-H) bond functionalization field. Indeed, the functionalization of building blocks that do not display a reactive functional group but only a simple C-H bond is attractive as it avoids time-consuming and expensive prefunctionalization steps and limits the generation of waste. However, as energies required to break C-H bonds are similar, the differentiation between two C-H bonds and the selective functionalization of only one of them remain a key challenge. Therefore, the available approaches are still unsatisfactory due to important limitations: low reactivity, limited scopes and selectivity issues. In this proposal, a general approach to functionalize a CH bond located at a Far position (from a functional group) by Catalysis (FarCatCH) will be implemented with a special focus on underexplored transformations, affording important sulfur-and fluorine-containing compounds. Herein, I will develop new synthetic approaches for the remote functionalization of molecules based on i) a substrate-selectivity control and ii) the design of new catalysts using supramolecular tools. I will then iii) address a longstanding reactivity issue in organic synthesis: the trifluoromethylation of aliphatic compounds and apply the supramolecular catalysts for a remote enantioselective transformation.

Designing a full set of tools as Swiss army knife for the selective functionalization at unconventional positions inaccessible so far, can considerably change the way organic molecules are made. These original technologies will offer new synthetic routes to access original sulfur- and fluorine-containing molecules, compounds of interest in drugs discovery, material sciences, pharmaceutical and agrochemical industry.

 Publications

year authors and title journal last update
List of publications.
2019 Jianjun Wang, Heng-Ying Xiong, Emilie Petit, Laëtitia Bailly, Xavier Pannecoucke, Thomas Poisson, Tatiana Besset
BiCl 3 -Mediated direct functionalization of unsaturated C–C bonds with an electrophilic SCF 2 PO(OEt) 2 reagent
published pages: , ISSN: 1359-7345, DOI: 10.1039/c9cc01851d
Chemical Communications 2019-08-05
2019 Elodie Carbonnel, Thomas Poisson, Philippe Jubault, Xavier Pannecoucke, Tatiana Besset
Recent Advances for the Direct Introduction of the CF2Me Moiety
published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2019.00111
Frontiers in Chemistry 7 2019-08-05
2018 Carlo Sambiagio, David Schönbauer, Remi Blieck, Toan Dao-Huy, Gerit Pototschnig, Patricia Schaaf, Thomas Wiesinger, Muhammad Farooq Zia, Joanna Wencel-Delord, Tatiana Besset, Bert U. W. Maes, Michael Schnürch
A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry
published pages: 6603-6743, ISSN: 0306-0012, DOI: 10.1039/C8CS00201K
Chemical Society Reviews 47/17 2019-06-07

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