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SUGARSmart SIGNED

SUGARSmart: Smart design of recombinant antibody fragments specific for carbohydrate molecules

Total Cost €

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EC-Contrib. €

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Partnership

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 SUGARSmart project word cloud

Explore the words cloud of the SUGARSmart project. It provides you a very rough idea of what is the project "SUGARSmart" about.

attempt    lectins    complete    spr    computationally    predictions    cell    experimental    hyperacute    explore    diseases    glycans    locations    mutants    smart    functionally    shuffling    predict    affinity    validity    immunity    framework    diagnosis    interdisciplinary    suited    strategies    polar    complexity    techniques    detection    mutations    rational    reagents    predicted    therapeutics    bioprosthetic    diagnostic    sites    alpha    limits    fragment    antibodies    sugarsmart    pathological    limited    antibody    validation    assays    transplantation    domains    molecules    models    tested    wise    diverse    coherent    normal    first    mutational    itc    structural    scfv    molecular    physio    gal    rejection    computational    pursued    pipeline    quantify    experiments    combining    workflow    modeling    recognition    elisa    single    engineering    interactions    aromatic    mutagenesis    glycan    chain    roles    anti    specificity    cancer    engineer    proposes    array   

Project "SUGARSmart" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-10   to  2020-07-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00

Map

 Project objective

The development of new approaches to explore the diverse role of glycans in normal and physio- pathological conditions of the cell is a major challenge. Our previous research recognized roles of anti-glycan recognition molecules (lectins and antibodies) in the diagnosis of diseases like cancer, immunity, and hyperacute rejection upon bioprosthetic transplantation etc. However, because of the structural complexity, well-established approaches for developing glycan-based therapeutics are limited.

To address this issues, SUGARSmart aims to develop a workflow for rational design of single-chain fragment variable (scFv) antibodies to enhance glycan recognition capabilities, both specificity- and affinity-wise (improving detection limits of assays). Three major aims will be pursued: First, we will apply molecular modeling to predict mutations which lead to enhance affinity and specificity of anti-αGal scFv. A range of mutational strategies will be tested in order to learn which scFv domains, which particular locations (functionally important sites), and which mutations (aromatic or polar) are best suited to improve affinity and specificity. Second, computationally predicted mutants will be obtained by mutagenesis or chain shuffling. Validity of the predictions will be tested by affinity-measurement (ITC/SPR), array techniques and ELISA. At the end, validation of computational models of scFv-glycan interactions with experimental techniques will enable us to propose a workflow to engineer other anti-glycan scFv antibodies.

Overall, this project proposes an interdisciplinary approach to enhance our ability to quantify and engineer glycan recognition molecules having potential application in the smart and tailored development of future diagnostic reagents and therapeutics. To the best of our knowledge this will be the first attempt to provide a complete and coherent framework for anti-glycan antibody engineering, combining a wide computational pipeline and experiments.

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The information about "SUGARSMART" are provided by the European Opendata Portal: CORDIS opendata.

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