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SUGARSmart SIGNED

SUGARSmart: Smart design of recombinant antibody fragments specific for carbohydrate molecules

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SUGARSmart project word cloud

Explore the words cloud of the SUGARSmart project. It provides you a very rough idea of what is the project "SUGARSmart" about.

techniques    fragment    locations    complete    itc    therapeutics    suited    sugarsmart    diseases    molecular    engineer    explore    aromatic    experiments    lectins    gal    predict    cancer    single    combining    first    interactions    scfv    proposes    glycan    modeling    recognition    spr    experimental    reagents    mutational    complexity    diagnosis    antibodies    anti    limits    sites    mutants    pipeline    affinity    engineering    functionally    array    cell    bioprosthetic    computationally    hyperacute    pathological    normal    wise    molecules    structural    antibody    models    rational    domains    interdisciplinary    coherent    pursued    strategies    chain    specificity    diagnostic    transplantation    roles    predictions    validation    predicted    computational    polar    framework    alpha    mutagenesis    assays    shuffling    elisa    attempt    diverse    quantify    rejection    detection    limited    validity    tested    glycans    smart    workflow    physio    immunity    mutations   

Project "SUGARSmart" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-10   to  2020-07-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00

Map

 Project objective

The development of new approaches to explore the diverse role of glycans in normal and physio- pathological conditions of the cell is a major challenge. Our previous research recognized roles of anti-glycan recognition molecules (lectins and antibodies) in the diagnosis of diseases like cancer, immunity, and hyperacute rejection upon bioprosthetic transplantation etc. However, because of the structural complexity, well-established approaches for developing glycan-based therapeutics are limited.

To address this issues, SUGARSmart aims to develop a workflow for rational design of single-chain fragment variable (scFv) antibodies to enhance glycan recognition capabilities, both specificity- and affinity-wise (improving detection limits of assays). Three major aims will be pursued: First, we will apply molecular modeling to predict mutations which lead to enhance affinity and specificity of anti-αGal scFv. A range of mutational strategies will be tested in order to learn which scFv domains, which particular locations (functionally important sites), and which mutations (aromatic or polar) are best suited to improve affinity and specificity. Second, computationally predicted mutants will be obtained by mutagenesis or chain shuffling. Validity of the predictions will be tested by affinity-measurement (ITC/SPR), array techniques and ELISA. At the end, validation of computational models of scFv-glycan interactions with experimental techniques will enable us to propose a workflow to engineer other anti-glycan scFv antibodies.

Overall, this project proposes an interdisciplinary approach to enhance our ability to quantify and engineer glycan recognition molecules having potential application in the smart and tailored development of future diagnostic reagents and therapeutics. To the best of our knowledge this will be the first attempt to provide a complete and coherent framework for anti-glycan antibody engineering, combining a wide computational pipeline and experiments.

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The information about "SUGARSMART" are provided by the European Opendata Portal: CORDIS opendata.

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