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SUGARSmart SIGNED

SUGARSmart: Smart design of recombinant antibody fragments specific for carbohydrate molecules

Total Cost €

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EC-Contrib. €

0

Partnership

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 SUGARSmart project word cloud

Explore the words cloud of the SUGARSmart project. It provides you a very rough idea of what is the project "SUGARSmart" about.

antibody    mutational    locations    modeling    molecular    chain    diagnosis    lectins    experiments    cancer    shuffling    mutagenesis    quantify    explore    elisa    hyperacute    roles    sugarsmart    reagents    engineer    sites    glycans    attempt    complete    diverse    molecules    itc    physio    smart    coherent    alpha    diseases    immunity    tested    computationally    engineering    limited    techniques    normal    complexity    mutants    limits    fragment    strategies    framework    pathological    array    proposes    polar    recognition    antibodies    first    diagnostic    structural    cell    validity    therapeutics    interactions    predictions    validation    computational    gal    suited    functionally    rational    bioprosthetic    spr    scfv    transplantation    single    glycan    workflow    pursued    detection    anti    assays    domains    models    interdisciplinary    predict    wise    pipeline    rejection    predicted    experimental    mutations    aromatic    affinity    combining    specificity   

Project "SUGARSmart" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-10   to  2020-07-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00

Map

 Project objective

The development of new approaches to explore the diverse role of glycans in normal and physio- pathological conditions of the cell is a major challenge. Our previous research recognized roles of anti-glycan recognition molecules (lectins and antibodies) in the diagnosis of diseases like cancer, immunity, and hyperacute rejection upon bioprosthetic transplantation etc. However, because of the structural complexity, well-established approaches for developing glycan-based therapeutics are limited.

To address this issues, SUGARSmart aims to develop a workflow for rational design of single-chain fragment variable (scFv) antibodies to enhance glycan recognition capabilities, both specificity- and affinity-wise (improving detection limits of assays). Three major aims will be pursued: First, we will apply molecular modeling to predict mutations which lead to enhance affinity and specificity of anti-αGal scFv. A range of mutational strategies will be tested in order to learn which scFv domains, which particular locations (functionally important sites), and which mutations (aromatic or polar) are best suited to improve affinity and specificity. Second, computationally predicted mutants will be obtained by mutagenesis or chain shuffling. Validity of the predictions will be tested by affinity-measurement (ITC/SPR), array techniques and ELISA. At the end, validation of computational models of scFv-glycan interactions with experimental techniques will enable us to propose a workflow to engineer other anti-glycan scFv antibodies.

Overall, this project proposes an interdisciplinary approach to enhance our ability to quantify and engineer glycan recognition molecules having potential application in the smart and tailored development of future diagnostic reagents and therapeutics. To the best of our knowledge this will be the first attempt to provide a complete and coherent framework for anti-glycan antibody engineering, combining a wide computational pipeline and experiments.

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The information about "SUGARSMART" are provided by the European Opendata Portal: CORDIS opendata.

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relatedResult rcn (658352) AGGIORNATO correttamente
lastchecktime (2021-03-05 22:55:48) correctly updated