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SONGBIRD SIGNED

SOphisticated 3D cell culture scaffolds for Next Generation Barrier-on-chip In vitro moDels

Total Cost €

EC-Contrib. €

Partnership

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SONGBIRD project word cloud

Explore the words cloud of the SONGBIRD project. It provides you a very rough idea of what is the project "SONGBIRD" about.

uses cells models vitro model molecules miniaturised unlock comprising toolbox urgent biologically validate cell sophisticated platform transformation neurodegenerative soft realising versatile scientific heterogeneous 3d box precise suspended generation passage population microsystem synthesis blood network structure tool gain types correlation medical mechanistic serve materials scaffolds expertise validated structured location reduce incorporate speed layer missing output nanotoxicology animal life completely million experimental barrier handle cultures run brain microfluidic songbird suitable ethical microfabrication engineering 10 mechanically free drugs chip ageing final economic pi biological drug 2d screening hydrogel science months animals physically platforms strictly diseases culture vivo vision relevance

Project "SONGBIRD" data sheet

The following table provides information about the project.

Coordinator	UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UPPSALA UNIVERSITET UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	coordinator	1˙500˙000.00

Map

Project objective

The blood-brain barrier is a sophisticated biological barrier comprising several different cell types, structured in a well-defined order with the task to strictly control the passage of molecules - such as drugs against neurodegenerative diseases - from the blood into the brain. To reduce the ethical and economic costs of drug development, which in EU today uses ~10 million experimental animals every year, we must develop in vitro models of the blood-brain barrier with high in vivo correlation, as these are completely missing today.

SONGBIRD aims to achieve this with the scientific approach to - Develop advanced microfabrication methods to handle biologically derived materials - Structure the materials into heterogeneous 3D multi-layer suspended cell culture scaffolds - Incorporate blood-brain barrier cells with precise control on location and order - Integrated the 3D scaffolds into a microfluidic network as a miniaturised screening platform

The vision is to develop and validate versatile microfabrication methods to mechanically structure and physically handle soft biological materials to unlock the use of next generation animal-free barrier-on-chip models that can be used to speed up drug development, serve as screening platforms for nanotoxicology and help medical researchers to gain mechanistic insight in drug delivery. During SONGBIRD, I will focus on the blood-brain barrier due to its urgent relevance for drug development for the ageing population but the final processing tool-box will be suitable for realising in vitro models of any biological barrier in the future.

SONGBIRD is proposed to run for 60 months and will include researchers with expertise in microsystem engineering (PI), hydrogel synthesis and drug delivery. The expected output is a validated 3D barrier-on-chip model as well as a microfabrication toolbox for biological materials enabling transformation from 2D to 3D cell cultures in several other life science research areas.

Publications

List of publications.
year	authors and title	journal	last update
2019	Anna Fornell, Carl Johannesson, Sean S. Searle, Axel Happstadius, Johan Nilsson, Maria Tenje An acoustofluidic platform for non-contact trapping of cell-laden hydrogel droplets compatible with optical microscopy published pages: 44101, ISSN: 1932-1058, DOI: 10.1063/1.5108583	Biomicrofluidics 13/4	2019-09-05

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The information about "SONGBIRD" are provided by the European Opendata Portal: CORDIS opendata.

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