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SONGBIRD SIGNED

SOphisticated 3D cell culture scaffolds for Next Generation Barrier-on-chip In vitro moDels

Total Cost €

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EC-Contrib. €

0

Partnership

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 SONGBIRD project word cloud

Explore the words cloud of the SONGBIRD project. It provides you a very rough idea of what is the project "SONGBIRD" about.

miniaturised    output    strictly    unlock    validated    cultures    engineering    comprising    run    network    microsystem    suitable    pi    platforms    generation    materials    expertise    model    ethical    nanotoxicology    gain    microfabrication    tool    versatile    realising    chip    speed    platform    population    ageing    animal    3d    uses    precise    serve    scientific    cells    experimental    physically    soft    toolbox    molecules    drugs    reduce    biologically    songbird    final    box    screening    culture    months    medical    models    types    vision    microfluidic    million    economic    mechanistic    vivo    incorporate    structured    scaffolds    10    hydrogel    blood    synthesis    handle    biological    drug    animals    urgent    passage    heterogeneous    vitro    location    suspended    free    brain    neurodegenerative    validate    correlation    structure    life    missing    science    transformation    sophisticated    mechanically    relevance    2d    layer    completely    barrier    diseases    cell   

Project "SONGBIRD" data sheet

The following table provides information about the project.

Coordinator
UPPSALA UNIVERSITET 

Organization address
address: VON KRAEMERS ALLE 4
city: UPPSALA
postcode: 751 05
website: www.uu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UPPSALA UNIVERSITET SE (UPPSALA) coordinator 1˙500˙000.00

Map

 Project objective

The blood-brain barrier is a sophisticated biological barrier comprising several different cell types, structured in a well-defined order with the task to strictly control the passage of molecules - such as drugs against neurodegenerative diseases - from the blood into the brain. To reduce the ethical and economic costs of drug development, which in EU today uses ~10 million experimental animals every year, we must develop in vitro models of the blood-brain barrier with high in vivo correlation, as these are completely missing today.

SONGBIRD aims to achieve this with the scientific approach to - Develop advanced microfabrication methods to handle biologically derived materials - Structure the materials into heterogeneous 3D multi-layer suspended cell culture scaffolds - Incorporate blood-brain barrier cells with precise control on location and order - Integrated the 3D scaffolds into a microfluidic network as a miniaturised screening platform

The vision is to develop and validate versatile microfabrication methods to mechanically structure and physically handle soft biological materials to unlock the use of next generation animal-free barrier-on-chip models that can be used to speed up drug development, serve as screening platforms for nanotoxicology and help medical researchers to gain mechanistic insight in drug delivery. During SONGBIRD, I will focus on the blood-brain barrier due to its urgent relevance for drug development for the ageing population but the final processing tool-box will be suitable for realising in vitro models of any biological barrier in the future.

SONGBIRD is proposed to run for 60 months and will include researchers with expertise in microsystem engineering (PI), hydrogel synthesis and drug delivery. The expected output is a validated 3D barrier-on-chip model as well as a microfabrication toolbox for biological materials enabling transformation from 2D to 3D cell cultures in several other life science research areas.

 Publications

year authors and title journal last update
List of publications.
2019 Anna Fornell, Carl Johannesson, Sean S. Searle, Axel Happstadius, Johan Nilsson, Maria Tenje
An acoustofluidic platform for non-contact trapping of cell-laden hydrogel droplets compatible with optical microscopy
published pages: 44101, ISSN: 1932-1058, DOI: 10.1063/1.5108583
Biomicrofluidics 13/4 2019-09-05

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The information about "SONGBIRD" are provided by the European Opendata Portal: CORDIS opendata.

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