BONDS TERMINATED
Bilayered ON-Demand Scaffolds: On-Demand Delivery from induced Pluripotent Stem Cell Derived Scaffolds for Diabetic Foot Ulcers
Total Cost €
0EC-Contrib. €
0Partnership
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0BONDS project word cloud
Explore the words cloud of the BONDS project. It provides you a very rough idea of what is the project "BONDS" about.
Project "BONDS" data sheet
The following table provides information about the project.
| Coordinator |
ROYAL COLLEGE OF SURGEONS IN IRELAND
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Total cost | 1˙372˙135 € |
| EC max contribution | 1˙372˙135 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-10-01 to 2022-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ROYAL COLLEGE OF SURGEONS IN IRELAND | IE (DUBLIN) | coordinator | 1˙372˙135.00 |
Map
Project objective
This program’s goal is to develop a scaffold using a new biomaterial source that is functionalised with on-demand delivery of genes for coordinated healing of diabetic foot ulcers (DFUs). DFUs are chronic wounds that are often recalcitrant to treatment, which devastatingly results in lower leg amputation. This project builds on the PI’s experience growing matrix from induced-pluripotent stem cell derived (iPS)-fibroblasts and in developing on-demand drug delivery technologies. The aim of this project is to first develop a SiPS: a scaffold from iPS-fibroblast grown matrix, which has never been tested as a source material for scaffolds. iPS-fibroblasts grow a more pro-repair and angiogenic matrix than (non-iPS) adult fibroblasts. The SiPS structure will be bilayered to mimic native skin: dermis made mostly by fibroblasts and epidermis made by keratinocytes. The dermal layer will consist of a porous scaffold with optimised pore size and mechanical properties and the epidermal layer will be film-like, optimised for keratinisation. Second, the SiPS will be functionalised with delivery of plasmid-DNA (platelet derived growth factor gene, pPDGF) to direct angiogenesis on-demand. As DFUs undergo uncoordinated healing, timed pPDGF delivery will guide them through angiogenesis and healing. To achieve this, alginate microparticles, designed to respond to ultrasound by releasing pPDGF, will be interspersed throughout the SiPS. This BONDS will be tested in an in vivo pre-clinical DFU model to confirm its ability to heal wounds by providing cells with the appropriate biomimetic scaffold environment and timed directions for healing. With >100 million current diabetics expected to get a DFU, the BONDS would have a powerful clinical impact. This research program combines a disruptive technology, the SiPS, with a new platform for on-demand delivery of pDNA to heal DFUs. The PI will build his lab around these innovative platforms, adapting them for treatment of diverse complex wounds.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Ronaldo J. F. C. do Amaral, Noora M. A. Zayed, Elena I. Pascu, Brenton Cavanagh, Chris Hobbs, Francesco Santarella, Christopher R. Simpson, Ciara M. Murphy, Rukmani Sridharan, Arlyng González-Vázquez, Barry O\'Sullivan, Fergal J. O\'Brien, Cathal J. Kearney Functionalising Collagen-Based Scaffolds With Platelet-Rich Plasma for Enhanced Skin Wound Healing Potential published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00371 |
Frontiers in Bioengineering and Biotechnology 7 | 2020-03-05 |
| 2019 |
Niusha Nikravesh, Owen G. Davies, Ioannis Azoidis, Richard J. A. Moakes, Lucia Marani, Mark Turner, Cathal J. Kearney, Neil M. Eisenstein, Liam M. Grover, Sophie C. Cox Physical Structuring of Injectable Polymeric Systems to Controllably Deliver Nanosized Extracellular Vesicles published pages: 1801604, ISSN: 2192-2640, DOI: 10.1002/adhm.201801604 |
Advanced Healthcare Materials 8/9 | 2020-01-28 |
| 2018 |
Ronaldo Jose Farias Correa Amaral, Brenton Cavanagh, Fergal Joseph O\'Brien, Cathal John Kearney Plateletâ€derived growth factor stabilises vascularisation in collagenâ€glycosaminoglycan scaffolds in vitro published pages: , ISSN: 1932-6254, DOI: 10.1002/term.2789 |
Journal of Tissue Engineering and Regenerative Medicine | 2020-01-28 |
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