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BONDS TERMINATED

Bilayered ON-Demand Scaffolds: On-Demand Delivery from induced Pluripotent Stem Cell Derived Scaffolds for Diabetic Foot Ulcers

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BONDS project word cloud

Explore the words cloud of the BONDS project. It provides you a very rough idea of what is the project "BONDS" about.

environment    source    first    material    guide    mostly    chronic    size    dfu    pluripotent    model    ppdgf    dermis    never    ulcers    epidermal    consist    bilayered    coordinated    lower    timed    mimic    made    heal    amputation    platform    clinical    healing    native    scaffold    dna    pore    vivo    foot    alginate    dfus    diabetic    diabetics    grown    keratinocytes    pro    ultrasound    film    lab    fibroblast    interspersed    million    mechanical    recalcitrant    repair    cell    direct    angiogenic    functionalised    fibroblasts    wounds    treatment    designed    biomimetic    technologies    adult    combines    leg    dermal    innovative    epidermis    microparticles    diverse    bonds    platelet    ips    grow    releasing    demand    powerful    tested    biomaterial    directions    devastatingly    skin    platforms    pdna    confirm    adapting    uncoordinated    sips    keratinisation    genes    drug    gene    builds    angiogenesis    structure    appropriate    pi    cells    layer    matrix    porous    gt    scaffolds    plasmid    disruptive    undergo    stem   

Project "BONDS" data sheet

The following table provides information about the project.

Coordinator		 ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Ireland [IE]
 Total cost 1˙372˙135 €
 EC max contribution 1˙372˙135 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 1˙372˙135.00

Map

 Project objective

This program’s goal is to develop a scaffold using a new biomaterial source that is functionalised with on-demand delivery of genes for coordinated healing of diabetic foot ulcers (DFUs). DFUs are chronic wounds that are often recalcitrant to treatment, which devastatingly results in lower leg amputation. This project builds on the PI’s experience growing matrix from induced-pluripotent stem cell derived (iPS)-fibroblasts and in developing on-demand drug delivery technologies. The aim of this project is to first develop a SiPS: a scaffold from iPS-fibroblast grown matrix, which has never been tested as a source material for scaffolds. iPS-fibroblasts grow a more pro-repair and angiogenic matrix than (non-iPS) adult fibroblasts. The SiPS structure will be bilayered to mimic native skin: dermis made mostly by fibroblasts and epidermis made by keratinocytes. The dermal layer will consist of a porous scaffold with optimised pore size and mechanical properties and the epidermal layer will be film-like, optimised for keratinisation. Second, the SiPS will be functionalised with delivery of plasmid-DNA (platelet derived growth factor gene, pPDGF) to direct angiogenesis on-demand. As DFUs undergo uncoordinated healing, timed pPDGF delivery will guide them through angiogenesis and healing. To achieve this, alginate microparticles, designed to respond to ultrasound by releasing pPDGF, will be interspersed throughout the SiPS. This BONDS will be tested in an in vivo pre-clinical DFU model to confirm its ability to heal wounds by providing cells with the appropriate biomimetic scaffold environment and timed directions for healing. With >100 million current diabetics expected to get a DFU, the BONDS would have a powerful clinical impact. This research program combines a disruptive technology, the SiPS, with a new platform for on-demand delivery of pDNA to heal DFUs. The PI will build his lab around these innovative platforms, adapting them for treatment of diverse complex wounds.

 Publications

year authors and title journal last update
List of publications.
2019 Ronaldo J. F. C. do Amaral, Noora M. A. Zayed, Elena I. Pascu, Brenton Cavanagh, Chris Hobbs, Francesco Santarella, Christopher R. Simpson, Ciara M. Murphy, Rukmani Sridharan, Arlyng González-Vázquez, Barry O\'Sullivan, Fergal J. O\'Brien, Cathal J. Kearney
Functionalising Collagen-Based Scaffolds With Platelet-Rich Plasma for Enhanced Skin Wound Healing Potential
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00371 		Frontiers in Bioengineering and Biotechnology 7 2020-03-05
2019 Niusha Nikravesh, Owen G. Davies, Ioannis Azoidis, Richard J. A. Moakes, Lucia Marani, Mark Turner, Cathal J. Kearney, Neil M. Eisenstein, Liam M. Grover, Sophie C. Cox
Physical Structuring of Injectable Polymeric Systems to Controllably Deliver Nanosized Extracellular Vesicles
published pages: 1801604, ISSN: 2192-2640, DOI: 10.1002/adhm.201801604 		Advanced Healthcare Materials 8/9 2020-01-28
2018 Ronaldo Jose Farias Correa Amaral, Brenton Cavanagh, Fergal Joseph O\'Brien, Cathal John Kearney
Platelet‐derived growth factor stabilises vascularisation in collagen‐glycosaminoglycan scaffolds in vitro
published pages: , ISSN: 1932-6254, DOI: 10.1002/term.2789 		Journal of Tissue Engineering and Regenerative Medicine 2020-01-28

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The information about "BONDS" are provided by the European Opendata Portal: CORDIS opendata.

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