Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. bonds

BONDS TERMINATED

Bilayered ON-Demand Scaffolds: On-Demand Delivery from induced Pluripotent Stem Cell Derived Scaffolds for Diabetic Foot Ulcers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 BONDS project word cloud

Explore the words cloud of the BONDS project. It provides you a very rough idea of what is the project "BONDS" about.

plasmid    lab    first    recalcitrant    clinical    adult    cells    functionalised    ppdgf    porous    size    scaffolds    environment    direct    directions    grown    leg    angiogenesis    powerful    healing    amputation    combines    ips    epidermis    source    dfus    native    microparticles    pdna    repair    diabetics    stem    devastatingly    builds    heal    layer    keratinisation    bonds    genes    lower    material    demand    appropriate    ultrasound    drug    ulcers    gt    treatment    foot    fibroblast    alginate    million    mostly    interspersed    dfu    timed    platform    platforms    dna    guide    platelet    grow    epidermal    model    diverse    designed    diabetic    gene    technologies    made    pro    scaffold    dermis    vivo    film    matrix    structure    wounds    chronic    bilayered    tested    cell    adapting    uncoordinated    pore    pluripotent    biomaterial    never    coordinated    biomimetic    skin    consist    mimic    mechanical    keratinocytes    confirm    angiogenic    sips    dermal    fibroblasts    disruptive    releasing    undergo    innovative    pi   

Project "BONDS" data sheet

The following table provides information about the project.

Coordinator		 ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Ireland [IE]
 Total cost 1˙372˙135 €
 EC max contribution 1˙372˙135 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 1˙372˙135.00

Map

 Project objective

This program’s goal is to develop a scaffold using a new biomaterial source that is functionalised with on-demand delivery of genes for coordinated healing of diabetic foot ulcers (DFUs). DFUs are chronic wounds that are often recalcitrant to treatment, which devastatingly results in lower leg amputation. This project builds on the PI’s experience growing matrix from induced-pluripotent stem cell derived (iPS)-fibroblasts and in developing on-demand drug delivery technologies. The aim of this project is to first develop a SiPS: a scaffold from iPS-fibroblast grown matrix, which has never been tested as a source material for scaffolds. iPS-fibroblasts grow a more pro-repair and angiogenic matrix than (non-iPS) adult fibroblasts. The SiPS structure will be bilayered to mimic native skin: dermis made mostly by fibroblasts and epidermis made by keratinocytes. The dermal layer will consist of a porous scaffold with optimised pore size and mechanical properties and the epidermal layer will be film-like, optimised for keratinisation. Second, the SiPS will be functionalised with delivery of plasmid-DNA (platelet derived growth factor gene, pPDGF) to direct angiogenesis on-demand. As DFUs undergo uncoordinated healing, timed pPDGF delivery will guide them through angiogenesis and healing. To achieve this, alginate microparticles, designed to respond to ultrasound by releasing pPDGF, will be interspersed throughout the SiPS. This BONDS will be tested in an in vivo pre-clinical DFU model to confirm its ability to heal wounds by providing cells with the appropriate biomimetic scaffold environment and timed directions for healing. With >100 million current diabetics expected to get a DFU, the BONDS would have a powerful clinical impact. This research program combines a disruptive technology, the SiPS, with a new platform for on-demand delivery of pDNA to heal DFUs. The PI will build his lab around these innovative platforms, adapting them for treatment of diverse complex wounds.

 Publications

year authors and title journal last update
List of publications.
2019 Ronaldo J. F. C. do Amaral, Noora M. A. Zayed, Elena I. Pascu, Brenton Cavanagh, Chris Hobbs, Francesco Santarella, Christopher R. Simpson, Ciara M. Murphy, Rukmani Sridharan, Arlyng González-Vázquez, Barry O\'Sullivan, Fergal J. O\'Brien, Cathal J. Kearney
Functionalising Collagen-Based Scaffolds With Platelet-Rich Plasma for Enhanced Skin Wound Healing Potential
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00371 		Frontiers in Bioengineering and Biotechnology 7 2020-03-05
2019 Niusha Nikravesh, Owen G. Davies, Ioannis Azoidis, Richard J. A. Moakes, Lucia Marani, Mark Turner, Cathal J. Kearney, Neil M. Eisenstein, Liam M. Grover, Sophie C. Cox
Physical Structuring of Injectable Polymeric Systems to Controllably Deliver Nanosized Extracellular Vesicles
published pages: 1801604, ISSN: 2192-2640, DOI: 10.1002/adhm.201801604 		Advanced Healthcare Materials 8/9 2020-01-28
2018 Ronaldo Jose Farias Correa Amaral, Brenton Cavanagh, Fergal Joseph O\'Brien, Cathal John Kearney
Platelet‐derived growth factor stabilises vascularisation in collagen‐glycosaminoglycan scaffolds in vitro
published pages: , ISSN: 1932-6254, DOI: 10.1002/term.2789 		Journal of Tissue Engineering and Regenerative Medicine 2020-01-28

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BONDS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BONDS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Cu4Peroxide (2020)

The electrochemical synthesis of hydrogen peroxide

Read More  

CHIPTRANSFORM (2018)

On-chip optical communication with transformation optics

Read More  

CUSTOMER (2019)

Customizable Embedded Real-Time Systems: Challenges and Key Techniques

Read More