EU H2020 Project "BONDS (Bilayered ON-Demand Scaffolds: On-Demand Delivery from induced Pluripotent..)": description, partecipants, costs and EC-fundings

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BONDS project word cloud

Explore the words cloud of the BONDS project. It provides you a very rough idea of what is the project "BONDS" about.

skin platelet leg grow gene scaffold timed microparticles innovative fibroblast mechanical releasing layer porous demand structure dfus directions pdna powerful grown fibroblasts matrix treatment designed million pluripotent uncoordinated material heal clinical diverse undergo amputation keratinocytes pro keratinisation builds dna appropriate dermis source adult technologies devastatingly drug lower alginate ppdgf platforms dermal epidermal disruptive cell never scaffolds made adapting bilayered confirm direct combines cells diabetics sips coordinated diabetic first ulcers model wounds recalcitrant stem gt film healing mostly consist pore functionalised plasmid interspersed guide tested ultrasound repair foot epidermis bonds biomimetic genes dfu environment mimic pi native platform biomaterial lab ips vivo chronic size angiogenesis angiogenic

Project "BONDS" data sheet

The following table provides information about the project.

Coordinator	ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	1˙372˙135 €
EC max contribution	1˙372˙135 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2022-09-30

#	participants	country	role	EC contrib. [€]
1	ROYAL COLLEGE OF SURGEONS IN IRELAND	IE (DUBLIN)	coordinator	1˙372˙135.00

ROYAL COLLEGE OF SURGEONS IN IRELAND

IE (DUBLIN)

coordinator

1˙372˙135.00

Project objective

This program’s goal is to develop a scaffold using a new biomaterial source that is functionalised with on-demand delivery of genes for coordinated healing of diabetic foot ulcers (DFUs). DFUs are chronic wounds that are often recalcitrant to treatment, which devastatingly results in lower leg amputation. This project builds on the PI’s experience growing matrix from induced-pluripotent stem cell derived (iPS)-fibroblasts and in developing on-demand drug delivery technologies. The aim of this project is to first develop a SiPS: a scaffold from iPS-fibroblast grown matrix, which has never been tested as a source material for scaffolds. iPS-fibroblasts grow a more pro-repair and angiogenic matrix than (non-iPS) adult fibroblasts. The SiPS structure will be bilayered to mimic native skin: dermis made mostly by fibroblasts and epidermis made by keratinocytes. The dermal layer will consist of a porous scaffold with optimised pore size and mechanical properties and the epidermal layer will be film-like, optimised for keratinisation. Second, the SiPS will be functionalised with delivery of plasmid-DNA (platelet derived growth factor gene, pPDGF) to direct angiogenesis on-demand. As DFUs undergo uncoordinated healing, timed pPDGF delivery will guide them through angiogenesis and healing. To achieve this, alginate microparticles, designed to respond to ultrasound by releasing pPDGF, will be interspersed throughout the SiPS. This BONDS will be tested in an in vivo pre-clinical DFU model to confirm its ability to heal wounds by providing cells with the appropriate biomimetic scaffold environment and timed directions for healing. With >100 million current diabetics expected to get a DFU, the BONDS would have a powerful clinical impact. This research program combines a disruptive technology, the SiPS, with a new platform for on-demand delivery of pDNA to heal DFUs. The PI will build his lab around these innovative platforms, adapting them for treatment of diverse complex wounds.

Publications

List of publications.
year	authors and title	journal	last update
2019	Ronaldo J. F. C. do Amaral, Noora M. A. Zayed, Elena I. Pascu, Brenton Cavanagh, Chris Hobbs, Francesco Santarella, Christopher R. Simpson, Ciara M. Murphy, Rukmani Sridharan, Arlyng GonzÃ¡lez-VÃ¡zquez, Barry O\'Sullivan, Fergal J. O\'Brien, Cathal J. Kearney Functionalising Collagen-Based Scaffolds With Platelet-Rich Plasma for Enhanced Skin Wound Healing Potential published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00371	Frontiers in Bioengineering and Biotechnology 7	2020-03-05
2019	Niusha Nikravesh, Owen G. Davies, Ioannis Azoidis, Richard J. A. Moakes, Lucia Marani, Mark Turner, Cathal J. Kearney, Neil M. Eisenstein, Liam M. Grover, Sophie C. Cox Physical Structuring of Injectable Polymeric Systems to Controllably Deliver Nanosized Extracellular Vesicles published pages: 1801604, ISSN: 2192-2640, DOI: 10.1002/adhm.201801604	Advanced Healthcare Materials 8/9	2020-01-28
2018	Ronaldo Jose Farias Correa Amaral, Brenton Cavanagh, Fergal Joseph O\'Brien, Cathal John Kearney Plateletâ€derived growth factor stabilises vascularisation in collagenâ€glycosaminoglycan scaffolds in vitro published pages: , ISSN: 1932-6254, DOI: 10.1002/term.2789	Journal of Tissue Engineering and Regenerative Medicine	2020-01-28

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