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Opendata, web and dolomites

SilkFUSION SIGNED

Genetically engineered human pluripotent stem cells, functionalized silk-fibroin platforms and bio-inks: a novel solution for large-scale ex-vivo platelet production, transfusion and drug research

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

SilkFUSION project word cloud

Explore the words cloud of the SilkFUSION project. It provides you a very rough idea of what is the project "SilkFUSION" about.

patients immunologically surgery 55 plts pathogenetic conflict gain transfusion ink precision hpscs wounded efficacy extremely physical proteins plt biomaterial bio biochemical ex vivo 3d platforms bone matched clinical therapies engineer platform mks megakaryocytes screening silk platelets functional optimized medical kits clinicians platelet trauma chip create predicting successful modified blood suited inherited supercharged mechanisms fibroin model engineering release vision alloimmunised instruments zones recombinant demand environment drug silkfusion pluripotent regarding reproducible fviia drugs transfusions dimensional molecules acute specialized strategies proven innovative disorders supply fold live containing therapeutic groundbreaking cells human marrow printing massive reducing prove genetically ineffective stem vitro generating affordable thrombocytopenic humans primary ing hypothesis nanotechnologies safety correct haemorrhage thrombogenic technological

Project "SilkFUSION" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI PAVIA Organization address address: STRADA NUOVA 65 city: PAVIA postcode: 27100 website: www.unipv.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	https://silkfusion.eu/
Total cost	2˙998˙500 €
EC max contribution	2˙998˙500 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-11-01 to 2021-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI PAVIA UNIVERSITA DEGLI STUDI DI PAVIA Organization address address: STRADA NUOVA 65 city: PAVIA postcode: 27100 website: www.unipv.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PAVIA)	coordinator	738˙327.00
2	INSTITUT GUSTAVE ROUSSY INSTITUT GUSTAVE ROUSSY Organization address address: Rue Camille Desmoulins 39 city: VILLEJUIF postcode: 94805 website: http://www.igr.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEJUIF)	participant	688˙327.00
3	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	688˙327.00
4	CELLINK AB CELLINK AB Organization address address: ARVID WALLGRENS BACKE 20 city: GOTEBORG postcode: 413 46 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOTEBORG)	participant	344˙163.00
5	INTEGRATED SYSTEMS ENGINEERING SRL INTEGRATED SYSTEMS ENGINEERING SRL Organization address address: Via Volturno CEDRI 80 city: BRUGHERIO postcode: 20816 website: www.isenet.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BRUGHERIO)	participant	319˙580.00
6	KNOWLEDGE INNOVATION MARKET S.L. KNOWLEDGE INNOVATION MARKET S.L. Organization address address: CALLE VENEZUELA 103 PLANTA 1 PUERTA city: BARCELONA postcode: 8019 website: www.kimglobal.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	219˙773.00

Map

Project objective

'The demand for human platelets (plts) for medical research and clinical applications is massive. The primary goal of SilkFUSION is to engineer groundbreaking 3D nanotechnologies for large-scale production of blood plts for human transfusion from human pluripotent stem cells (hPSCs). Our hypothesis is that plt production ex-vivo can be optimized by providing megakaryocytes (Mks) with the correct physical and biochemical environment.

To prove this, we will develop a unique technological platform by engineering non-thrombogenic silk-fibroin biomaterial with proteins, that were proven to promote a 55-fold gain in plt production, to create a three-dimensional ex-vivo bone marrow model that will enhance plt release from Mks derived from hPSCs. Our platform will include (i) novel applications to study pathogenetic mechanisms in patients with inherited platelet production disorders using genetically modified hPSCs; (ii) screening technology for predicting therapeutic efficacy of drugs for thrombocytopenic patients. The development of this technology will exploit an extremely innovative approach using silk-fibroin as a bio-ink for 3D printing a 'live chip' containing viable Mks for reproducible drug testing.

Our long-term vision is to foster the production of plts in-vitro for clinical transfusions in humans at a scale and cost that will address current supply challenges regarding (i) immunologically matched products to alloimmunised patients; (ii) “supercharged” platelets with recombinant FVIIa generating plts specifically suited for patients with acute haemorrhage resulting from trauma, surgery and wounded in conflict zones. The successful development and distribution of the SilkFUSION platforms will also offer researchers and clinicians specialized precision instruments and bio-ink kits for determining the safety and efficacy of drugs, reducing costs of ineffective therapies while promoting affordable functional strategies for the development of novel molecules.'

Deliverables

List of deliverables.
Public Project website	Websites, patent fillings, videos etc.	2020-03-18 18:53:14
Targeted stakeholders identified and informed about the project_12	Documents, reports	2020-03-18 18:53:14
Workshops_12	Documents, reports	2020-03-18 18:53:14

Take a look to the deliverables list in detail: detailed list of SilkFUSION deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Lorenzo Tozzi, Pierre-Alexandre Laurent, Christian A. Di Buduo, Xuan Mu, Angelo Massaro, Ross Bretherton, Whitney Stoppel, David L. Kaplan, Alessandra Balduini Multi-channel silk sponge mimicking bone marrow vascular niche for platelet production published pages: 122-133, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.06.018	Biomaterials 178	2020-03-18
2018	Jennifer H. Shepherd, Daniel Howard, Amie K. Waller, Holly Rebecca Foster, Annett Mueller, Thomas Moreau, Amanda L. Evans, Meera Arumugam, GuÃ©naÃ«lle BouÃ«t Chalon, Eleonora Vriend, Natalia Davidenko, Cedric Ghevaert, Serena M. Best, Ruth E. Cameron Structurally graduated collagen scaffolds applied to the ex vivo generation of platelets from human pluripotent stem cell-derived megakaryocytes: Enhancing production and purity published pages: 135-144, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.08.019	Biomaterials 182	2020-03-18

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The information about "SILKFUSION" are provided by the European Opendata Portal: CORDIS opendata.

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