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SilkFUSION SIGNED

Genetically engineered human pluripotent stem cells, functionalized silk-fibroin platforms and bio-inks: a novel solution for large-scale ex-vivo platelet production, transfusion and drug research

Total Cost €

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EC-Contrib. €

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Partnership

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 SilkFUSION project word cloud

Explore the words cloud of the SilkFUSION project. It provides you a very rough idea of what is the project "SilkFUSION" about.

platform    ink    patients    bio    clinical    human    mks    hpscs    silkfusion    3d    drugs    plts    fibroin    ex    efficacy    plt    vivo    silk    platelets   

Project "SilkFUSION" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PAVIA 

Organization address
address: STRADA NUOVA 65
city: PAVIA
postcode: 27100
website: www.unipv.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙998˙500 €
 EC max contribution 2˙998˙500 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme /RIA
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) coordinator 738˙327.00
2    Institut Gustave Roussy FR (VILLEJUIF) participant 688˙327.00
3    THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 688˙327.00
4    CELLINK AB SE (GOTHENBURG) participant 344˙163.00
5    INTEGRATED SYSTEMS ENGINEERING SRL IT (BRUGHERIO) participant 319˙580.00
6    KNOWLEDGE INNOVATION MARKET S.L. ES (BARCELONA) participant 219˙773.00

Mappa

 Project objective

'The demand for human platelets (plts) for medical research and clinical applications is massive. The primary goal of SilkFUSION is to engineer groundbreaking 3D nanotechnologies for large-scale production of blood plts for human transfusion from human pluripotent stem cells (hPSCs). Our hypothesis is that plt production ex-vivo can be optimized by providing megakaryocytes (Mks) with the correct physical and biochemical environment.

To prove this, we will develop a unique technological platform by engineering non-thrombogenic silk-fibroin biomaterial with proteins, that were proven to promote a 55-fold gain in plt production, to create a three-dimensional ex-vivo bone marrow model that will enhance plt release from Mks derived from hPSCs. Our platform will include (i) novel applications to study pathogenetic mechanisms in patients with inherited platelet production disorders using genetically modified hPSCs; (ii) screening technology for predicting therapeutic efficacy of drugs for thrombocytopenic patients. The development of this technology will exploit an extremely innovative approach using silk-fibroin as a bio-ink for 3D printing a 'live chip' containing viable Mks for reproducible drug testing.

Our long-term vision is to foster the production of plts in-vitro for clinical transfusions in humans at a scale and cost that will address current supply challenges regarding (i) immunologically matched products to alloimmunised patients; (ii) “supercharged” platelets with recombinant FVIIa generating plts specifically suited for patients with acute haemorrhage resulting from trauma, surgery and wounded in conflict zones. The successful development and distribution of the SilkFUSION platforms will also offer researchers and clinicians specialized precision instruments and bio-ink kits for determining the safety and efficacy of drugs, reducing costs of ineffective therapies while promoting affordable functional strategies for the development of novel molecules.'

 Work performed, outcomes and results:  advancements report(s) 

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The information about "SILKFUSION" are provided by the European Opendata Portal: CORDIS opendata.

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