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CHANNELMAT SIGNED

Microchannels for controlling cellular mechanotransduction

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CHANNELMAT" data sheet

The following table provides information about the project.

Coordinator
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL 

Organization address
address: OLSHAUSENSTRASSE 40
city: KIEL
postcode: 24118
website: http://www.uni-kiel.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL DE (KIEL) coordinator 150˙000.00

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 Project objective

Cells respond to external mechanical stimuli through an activation of a cellular mechanism called mechanotransduction. The cellular responses in this mechanism are expressed by a modification in cellular proliferation, migration and differentiation, as well as in a strengthening of their adhesion. Likewise, diseases such as cancer and cardiac dysfunctions are also related to cellular mechanotransduction. Here we propose to take a novel 3D material porous material towards commercial applications. The material serves as a platform for controlling mechanotransduction (e.g. in implant materials) and enables a control of mechanotransduction by mimicking natural 3D cellular environments. Our material contains a novel form of microporous structures represented by micron-sized channels embedded in a polymer matrix of a well-defined stiffness that has been developed within the ERC project CELLINSPIRED. The material guarantees pore interconnectivity independently of pore density and size, a unique feature offered by our fabrication procedure, for which we have applied for a patent (EP 15166793.8, PCT/EP2016/060160). Furthermore, it also provides a large, three-dimensionally controlled cell-surface contact area, such that the mechanical properties of the environment will have large impact on the cells. Our goal in this project is to validate our novel material for cellular applications where mechanotransduction is targeted. The expected outcome of our project is to receive a demonstrator material that (1) has well-defined mechanical properties, porosities and pore dimensions, (2) is biocompatible and can be sterilized, (3) can be fabricated in different levels of complexity, (4) can activate mechanotransduction in cells, and (5) can be fabricated using high-throughput processes. As for commercialization, we aim to license the patent to biomaterials companies involved in applications that range from 3D cell cultures to implant materials.

 Publications

year authors and title journal last update
List of publications.
2019 Mohammadreza Taale, Fabian Schütt, Tian Carey, Janik Marx, Yogendra Kumar Mishra, Norbert Stock, Bodo Fiedler, Felice Torrisi, Rainer Adelung, Christine Selhuber-Unkel
Biomimetic Carbon Fiber Systems Engineering: A Modular Design Strategy To Generate Biofunctional Composites from Graphene and Carbon Nanofibers
published pages: 5325-5335, ISSN: 1944-8244, DOI: 10.1021/acsami.8b17627
ACS Applied Materials & Interfaces 11/5 2019-06-06
2019 Sören B. Gutekunst, Katharina Siemsen, Steven Huth, Anneke Möhring, Britta Hesseler, Michael Timmermann, Ingo Paulowicz, Yogendra Kumar Mishra, Leonard Siebert, Rainer Adelung, Christine Selhuber-Unkel
3D Hydrogels Containing Interconnected Microchannels of Subcellular Size for Capturing Human Pathogenic Acanthamoeba Castellanii
published pages: 1784-1792, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.8b01009
ACS Biomaterials Science & Engineering 5/4 2019-06-06

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