Explore the words cloud of the PRESTIGE-AF project. It provides you a very rough idea of what is the project "PRESTIGE-AF" about.
The following table provides information about the project.
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
|Coordinator Country||United Kingdom [UK]|
|Total cost||6˙958˙896 €|
|EC max contribution||6˙958˙896 € (100%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2017-12-01 to 2022-11-30|
Take a look of project's partnership.
|1||IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE||UK (LONDON)||coordinator||3˙332˙520.00|
|2||UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT||DE (WURZBURG)||participant||1˙019˙373.00|
|3||FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA||ES (BARCELONA)||participant||468˙398.00|
|4||UNIVERSITATSKLINIKUM HEIDELBERG||DE (HEIDELBERG)||participant||447˙700.00|
|5||MEDIZINISCHE UNIVERSITAT GRAZ||AT (GRAZ)||participant||343˙300.00|
|6||KING'S COLLEGE LONDON||UK (LONDON)||participant||340˙000.00|
|7||UNIVERSITE DE BORDEAUX||FR (BORDEAUX)||participant||330˙609.00|
|8||JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG||DE (WUERZBURG)||participant||283˙372.00|
|9||THE UNIVERSITY OF LIVERPOOL||UK (LIVERPOOL)||participant||116˙562.00|
|10||AZIENDA OSPEDALIERA DI PERUGIA||IT (PERUGIA)||participant||115˙012.00|
|11||REGION NORDJYLLAND (NORTH DENMARK REGION)||DK (AALBORG)||participant||112˙500.00|
|12||STROKE ALLIANCE FOR EUROPE||BE (BRUSSELS)||participant||45˙000.00|
|13||THE UNIVERSITY OF BIRMINGHAM||UK (BIRMINGHAM)||participant||4˙547.00|
Intracerebral hemorrhage (ICH) is a severe stroke subtype causing higher mortality and more disability than other strokes. 20% of ICH survivors have atrial fibrillation (AF), a major cause of ischemic stroke (IS). While IS in AF patients is generally prevented by oral anticoagulants (OAC), their use in ICH survivors is uncertain due to increased bleeding risk. No evidence from randomized controlled trials (RCT) is available addressing this dilemma. Personalized risk prediction is desirable to balance benefits of OAC against bleeding risk for individualized prevention.
Objectives: (1) To perform the first sufficiently powered RCT in ICH survivors with AF testing if direct OAC are superior for IS prevention and non-inferior regarding ICH recurrence versus antiplatelet or no antithrombotic therapy (2) To personalize antithrombotic prevention by multidimensional risk modeling (3) To estimate population impact of trial outputs on health economic consequences and generalizability to European population (4) To explore patient-centered aspects including adherence, attitudes towards antithrombotic therapy and gender imbalances in trial enrollment.
Methods: Prospective, open RCT with blinded outcome assessment. Hierarchical sequential testing of co-primary endpoint IS and recurrent ICH. Sample size: 662 patients. RCT will recruit in 70 centers in 6 countries over 2 years with 2 year follow-up. Clinical characteristics, MRI, blood-biomarkers and genetics will be characterized at baseline to model a new personalized risk prediction tool.
Relevance for work program: PRESTIGE-AF addresses the unmet need of best antithrombotic stroke prevention in ICH patients with AF. Recurrent stroke reduces individual life expectancy, quality of life and has high public health impact. Work packages integrating biological data will generate new tools to tailor prevention. Modeling of economic and societal consequences and replication in real-life settings will estimate population impact.
|First study subject approvals package||Documents, reports||2020-03-24 00:29:29|
|Educational video onâ€œSample Collection Methods for Biomarker Studiesâ€||Websites, patent fillings, videos etc.||2020-03-24 00:29:29|
|PRESTIGE-AF â€œDissemination Packageâ€||Other||2020-03-24 00:29:29|
|Launch of website and social media accounts||Websites, patent fillings, videos etc.||2020-03-24 00:29:29|
|Dissemination & Communication Plan||Documents, reports||2020-03-24 00:29:29|
Take a look to the deliverables list in detail: detailed list of PRESTIGE-AF deliverables.
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The information about "PRESTIGE-AF" are provided by the European Opendata Portal: CORDIS opendata.
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