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TissueLymphoContexts SIGNED

Tissue-resident Lymphocytes: Development and Function in “real-life” Contexts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TissueLymphoContexts project word cloud

Explore the words cloud of the TissueLymphoContexts project. It provides you a very rough idea of what is the project "TissueLymphoContexts" about.

generation    surveillance    lung    line    induce    repair    cd8    resident    immunity    summary    barrier    alter    living    networks    defense    abundance    mucosal    representing    dramatically    first    functions    composition    bdquo    infection    canonical    tissue    most    induction    pathogens    pools    compartments    exposed    environments    cellular    array    pathogen    microbial    regulate    resistant    effector    human    strategy    alterations    basal    polyclonal    surfaces    homeostasis    immune    microbiota    models    trms    contexts    anatomical    inflammatory    environmental    restore    spaces    orchestrate    laboratory    infections    free    function    vascular    interactions    memory    bacteria    mechanisms    clinical    experimental    tissues    life    spf    vaccination    disease    solid    physiologic    hospitalized    local    men    types    exposure    cells    mirror    patients    antigenically    activation    host    front    invasion    reveal    fundamental    lymphocytes    symbionts    explore    mice    protection    kept    immunotherapy    physiology    organs   

Project "TissueLymphoContexts" data sheet

The following table provides information about the project.

Coordinator
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG 

Organization address
address: SANDERRING 2
city: WUERZBURG
postcode: 97070
website: http://www.uni-wuerzburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) coordinator 1˙498˙750.00

Map

 Project objective

Most anatomical compartments, including mucosal barrier surfaces, solid organs and vascular spaces host different types of tissue-resident lymphocytes providing local networks for immune surveillance and front-line defense to microbial invasion. In addition to immediate effector functions, tissue-resident lymphocytes orchestrate and regulate inflammatory responses, and contribute to tissue homeostasis, repair and barrier function. Understanding the generation and function of tissue-resident lymphocytes is therefore expected to reveal targets for improving vaccination and immunotherapy. Barrier tissues of free-living mice and men, but not those of laboratory mice kept under specific pathogen free conditions, are continuously exposed to an array of antigenically complex pathogens, microbial symbionts and environmental factors, which dramatically alter the abundance, composition and basal activation state of local pools of tissue-resident cells. Therefore, we propose to study the development, functions and cellular interactions of tissue-resident lymphocytes in experimental models that mirror “real-life” contexts. First, we will investigate how polyclonal pools of tissue-resident memory CD8 T cells (TRMs) are established during infection with antigenically complex pathogens. Second, we will restore physiologic exposure to specific pathogens and induce alterations of local microbiota in SPF mice, in order to investigate the induction, function and local interactions of tissue-resident lymphocytes in physiologic tissue environments. In addition, we will explore targeted microbial exposure as a „vaccination“ strategy to induce „non-canonical“ tissue-resident cells in the lung in order to improve protection against infections with multi-resistant bacteria representing major clinical problems in hospitalized patients. In summary, we will investigate fundamental mechanisms of tissue immunity and vaccination in contexts relevant for human physiology and disease.

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The information about "TISSUELYMPHOCONTEXTS" are provided by the European Opendata Portal: CORDIS opendata.

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