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TissueLymphoContexts SIGNED

Tissue-resident Lymphocytes: Development and Function in “real-life” Contexts

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TissueLymphoContexts project word cloud

Explore the words cloud of the TissueLymphoContexts project. It provides you a very rough idea of what is the project "TissueLymphoContexts" about.

front    lung    cd8    homeostasis    defense    alterations    organs    mucosal    contexts    representing    clinical    free    orchestrate    infections    barrier    first    environments    networks    dramatically    polyclonal    vaccination    resistant    solid    pathogen    cellular    function    restore    most    composition    array    invasion    strategy    line    microbiota    mechanisms    pathogens    microbial    immunity    activation    surfaces    basal    men    pools    inflammatory    types    host    spaces    living    human    cells    surveillance    exposed    abundance    alter    physiology    disease    environmental    generation    immunotherapy    compartments    memory    antigenically    mice    effector    life    regulate    mirror    protection    patients    reveal    experimental    vascular    induce    tissue    functions    models    interactions    canonical    exposure    anatomical    trms    hospitalized    local    immune    physiologic    lymphocytes    bacteria    infection    summary    resident    kept    tissues    repair    induction    explore    spf    laboratory    bdquo    fundamental    symbionts   

Project "TissueLymphoContexts" data sheet

The following table provides information about the project.

Coordinator
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG 

Organization address
address: SANDERRING 2
city: WUERZBURG
postcode: 97070
website: http://www.uni-wuerzburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) coordinator 1˙498˙750.00

Map

 Project objective

Most anatomical compartments, including mucosal barrier surfaces, solid organs and vascular spaces host different types of tissue-resident lymphocytes providing local networks for immune surveillance and front-line defense to microbial invasion. In addition to immediate effector functions, tissue-resident lymphocytes orchestrate and regulate inflammatory responses, and contribute to tissue homeostasis, repair and barrier function. Understanding the generation and function of tissue-resident lymphocytes is therefore expected to reveal targets for improving vaccination and immunotherapy. Barrier tissues of free-living mice and men, but not those of laboratory mice kept under specific pathogen free conditions, are continuously exposed to an array of antigenically complex pathogens, microbial symbionts and environmental factors, which dramatically alter the abundance, composition and basal activation state of local pools of tissue-resident cells. Therefore, we propose to study the development, functions and cellular interactions of tissue-resident lymphocytes in experimental models that mirror “real-life” contexts. First, we will investigate how polyclonal pools of tissue-resident memory CD8 T cells (TRMs) are established during infection with antigenically complex pathogens. Second, we will restore physiologic exposure to specific pathogens and induce alterations of local microbiota in SPF mice, in order to investigate the induction, function and local interactions of tissue-resident lymphocytes in physiologic tissue environments. In addition, we will explore targeted microbial exposure as a „vaccination“ strategy to induce „non-canonical“ tissue-resident cells in the lung in order to improve protection against infections with multi-resistant bacteria representing major clinical problems in hospitalized patients. In summary, we will investigate fundamental mechanisms of tissue immunity and vaccination in contexts relevant for human physiology and disease.

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The information about "TISSUELYMPHOCONTEXTS" are provided by the European Opendata Portal: CORDIS opendata.

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