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MASTFAST

Rapid production of HUMAN MAST CELLS

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MASTFAST project word cloud

Explore the words cloud of the MASTFAST project. It provides you a very rough idea of what is the project "MASTFAST" about.

hematopoietic    healing    validate    differentiation    personalized    strategies    implicated    wound    too    yields    anaphylaxsis    time    mucosal    normal    culture    autism    breaking    stem    translate    calls    hampered    engineered    few    inability    fatigue    optimize    chronic    airways    granules    intestinal    mast    molecules    interact    dysmotility    ground    enrichment    mouse    goals    rapid    pain    patient    components    escs    population    industry    bone    grow    adg    mutant    unexpected    erc    dysregulation    made    ige    hesc    crispr    phenotypic    treatments    12    complement    marrow    release    produces    embryonic    discovery    cultures    reporter    homogenous    cas9    pathogen    gene    drug    limit    angiogenesis    treatment    341096    human    allergic    medicine    weeks    esc    skin    alternative    allergies    dysfunction    cell    syndrome    instead    tissue    mastocytoma    proteases    activated    damage    cells    functional    connective    function    hescs    damaging   

Project "MASTFAST" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 148˙914 €
 EC max contribution 148˙914 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 148˙914.00

Map

 Project objective

Mast cells are involved in the allergic response, anaphylaxsis, wound healing and angiogenesis. When activated via IgE, damage/pathogen-induced molecules or complement components, the granules of mast cells release proteases. Dysregulation of mast cells is implicated in allergies of the skin and airways, autism, chronic fatigue syndrome, pain, mastocytoma and intestinal dysmotility. Strategies to limit the damaging effects of mast calls are needed. However, the development of novel treatments is hampered by the inability to grow mast cells rapidly and efficiently in culture. Bone marrow cell cultures typically take 12 weeks before mast cells are available for study. Even then, there are too few cells to use for drug discovery or patient-specific treatment strategies. Embryonic stem cells (ESC) represent an alternative method for the production of mast cells. An unexpected ground-breaking discovery from our ERC AdG 341096 studies aiming to produce hematopoietic stem cells, was the development of a novel method that instead produces large numbers of mast cells in a short time. Mouse ESC engineered with a unique reporter gene that allows for cell enrichment during a multi-step culture yields a homogenous population of phenotypic and functional connective tissue and mucosal mast cells. Within only 3 weeks large numbers of mast cells are generated. To translate this method for large scale rapid production of human mast cells we will 1) characterize unique human reporter ESCs made by Crispr/CAS9 state-of-the-art method; 2) optimize human mast cell production from reporter hESCs in a multi-step differentiation culture; 3) characterize/validate the function of hESC-derived mast cells (normal and mutant); 4) interact with industry to use hESC-derived mast cells for drug-discovery and studies of mast cell differentiation and dysfunction. Long-term goals include the development of mast cell treatment strategies for personalized medicine.

 Publications

year authors and title journal last update
List of publications.
2018 Mari-Liis Kauts, Bianca De Leo, Carmen Rodríguez-Seoane, Roger Ronn, Fokion Glykofrydis, Antonio Maglitto, Polynikis Kaimakis, Margarita Basi, Helen Taylor, Lesley Forrester, Adam C. Wilkinson, Berthold Göttgens, Philippa Saunders, Elaine Dzierzak
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells
published pages: 1009-1020, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.08.007
Stem Cell Reports 11/4 2020-01-23

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