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MASTFAST

Rapid production of HUMAN MAST CELLS

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MASTFAST project word cloud

Explore the words cloud of the MASTFAST project. It provides you a very rough idea of what is the project "MASTFAST" about.

chronic    release    made    activated    interact    crispr    fatigue    functional    mutant    human    function    341096    allergies    cas9    healing    wound    stem    normal    personalized    cultures    mastocytoma    calls    intestinal    damage    produces    escs    too    enrichment    cells    medicine    rapid    dysfunction    validate    goals    optimize    patient    mast    time    proteases    pathogen    embryonic    drug    reporter    marrow    instead    hampered    bone    few    skin    breaking    granules    treatment    esc    dysmotility    implicated    industry    ige    adg    hescs    tissue    pain    components    homogenous    complement    gene    unexpected    dysregulation    ground    angiogenesis    differentiation    erc    alternative    mouse    weeks    hematopoietic    autism    yields    population    airways    cell    grow    engineered    syndrome    discovery    treatments    molecules    connective    strategies    damaging    inability    anaphylaxsis    mucosal    hesc    allergic    translate    culture    12    phenotypic    limit   

Project "MASTFAST" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 148˙914 €
 EC max contribution 148˙914 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 148˙914.00

Map

 Project objective

Mast cells are involved in the allergic response, anaphylaxsis, wound healing and angiogenesis. When activated via IgE, damage/pathogen-induced molecules or complement components, the granules of mast cells release proteases. Dysregulation of mast cells is implicated in allergies of the skin and airways, autism, chronic fatigue syndrome, pain, mastocytoma and intestinal dysmotility. Strategies to limit the damaging effects of mast calls are needed. However, the development of novel treatments is hampered by the inability to grow mast cells rapidly and efficiently in culture. Bone marrow cell cultures typically take 12 weeks before mast cells are available for study. Even then, there are too few cells to use for drug discovery or patient-specific treatment strategies. Embryonic stem cells (ESC) represent an alternative method for the production of mast cells. An unexpected ground-breaking discovery from our ERC AdG 341096 studies aiming to produce hematopoietic stem cells, was the development of a novel method that instead produces large numbers of mast cells in a short time. Mouse ESC engineered with a unique reporter gene that allows for cell enrichment during a multi-step culture yields a homogenous population of phenotypic and functional connective tissue and mucosal mast cells. Within only 3 weeks large numbers of mast cells are generated. To translate this method for large scale rapid production of human mast cells we will 1) characterize unique human reporter ESCs made by Crispr/CAS9 state-of-the-art method; 2) optimize human mast cell production from reporter hESCs in a multi-step differentiation culture; 3) characterize/validate the function of hESC-derived mast cells (normal and mutant); 4) interact with industry to use hESC-derived mast cells for drug-discovery and studies of mast cell differentiation and dysfunction. Long-term goals include the development of mast cell treatment strategies for personalized medicine.

 Publications

year authors and title journal last update
List of publications.
2018 Mari-Liis Kauts, Bianca De Leo, Carmen Rodríguez-Seoane, Roger Ronn, Fokion Glykofrydis, Antonio Maglitto, Polynikis Kaimakis, Margarita Basi, Helen Taylor, Lesley Forrester, Adam C. Wilkinson, Berthold Göttgens, Philippa Saunders, Elaine Dzierzak
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells
published pages: 1009-1020, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.08.007
Stem Cell Reports 11/4 2020-01-23

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