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EpiCBiome SIGNED

Development of an innovative Airway-on-Chip microbiome cell culture model to investigate host-microbiome interactions at the airway epithelial surface

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "EpiCBiome" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.lumc.nl/org/longziekten/research/105681/
 Total cost 162˙864 €
 EC max contribution 162˙864 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 162˙864.00
2    EMULATE INC US (BOSTON) partner 0.00

Map

 Project objective

Patients with chronic inflammatory lung diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD) have a higher prevalence of respiratory infections. These infections accelerate disease progression and are associated with substantial morbidity and (especially in COPD) even mortality. Recent studies show that the airway microbiome of patients with asthma and COPD is different from that of healthy subjects. In murine lungs this has been shown to promote airway inflammation and loss of lung function. To this point it is unclear how changes in microbiome composition contribute to susceptibility for respiratory infections. Currently, treatment of patients with asthma and COPD is limited to symptom reduction and prevention of disease progression and hampered by the large amount of patients resistant to corticosteroid treatment. Understanding why these patients have an altered microbiome and increased susceptibility to respiratory infections is therefore pivotal to develop more effective healthcare strategies. Studies on host-microbiome interactions are mostly performed in murine models of airway diseases. Unfortunately, these models often fail to accurately reflect human disease. However, the recent development of Organ-on-a-Chip technology has effectively recapitulated many features of the modelled organ, thereby adding a level of complexity to cell cultures that is urgently needed. In contrast to existing airway epithelial cell cultures, these models contain several cell types, cultured at the air-liquid interface under a constant flow of air and nutrients while exposed to mechanical stress. However, also these cultures still lack an essential component of the airways: the airway microbiome. Therefore, the work described in this proposal aims to create an innovative human state-of-the-art Airway-on-Chip microbiome model to investigate the interaction of the airway epithelium with the microbiome and how this is linked to susceptibility for infection.

 Publications

year authors and title journal last update
List of publications.
2018 Anne van der Does, Gimano Amatngalim, Bart Keijser, Pieter Hiemstra, Remi Villenave
Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases
published pages: 49, ISSN: 2076-393X, DOI: 10.3390/vaccines6030049
Vaccines 6/3 2019-10-29

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