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GUT3D-PLATE SIGNED

Ready-to-use cell culture plates for gut 3D models

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GUT3D-PLATE project word cloud

Explore the words cloud of the GUT3D-PLATE project. It provides you a very rough idea of what is the project "GUT3D-PLATE" about.

inserts    benefit    fabricate    architecture    modeling    intestinal    reduce    analyzing    platforms    intestine    predict    efficacy    stages    reproducible    plate    gut3d    societal    device    manner    plan    biomedical    tools    compatible    cros    explore    microbiome    models    screening    comiet    conventional    treatment    feasibility    crypt    accurately    toxicity    specialized    vitro    animal    mimic    substrates    primary    human    dimensions    light    attract    generating    attractive    ipr    devoted    investing    mechanical    printing    lack    soft    culture    drug    commercial    villus    provides    morphologies    assays    capacities    innovative    efforts    cells    generation    lines    mimicking    physiology    poc    business    significantly    cell    industry    commercialize    investors    predictive    materials    3d    customize    protecting    proper    designing    community    erc    obtain    market    roadmap    scaffolds    hydrogel    disease    pharma    tissue    interactions    ease    ready   

Project "GUT3D-PLATE" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 150˙000.00

Map

 Project objective

3D cell culture models are considered the next-generation in vitro models. Several efforts are being devoted to better mimic human physiology and predict drug efficacy. In case of the intestinal tissue models, the 3D architecture of the intestinal tissue and the soft mechanical properties have been identified as key factors to obtain models with improved predictive capacities. However, there is a lack of low-cost and ease-to-use intestinal tissue models that encompass both elements. In the COMIET ERC project, we developed 3D cell culture scaffolds that accurately mimic the villus and crypt morphologies of the human intestine using soft materials. We used an innovative light-based approach to fabricate hydrogel scaffolds with the proper dimensions and mechanical properties of the tissue, in a reproducible manner. This ERC PoC GUT3D-PLATE will develop further the technology and customize a 3D low cost printing device to be able to fabricate ready-to-commercialize 3D cell culture substrates mimicking the intestinal physiology. These substrates will be provided as ready-to-use cell culture inserts, compatible with conventional assays and without the need of specialized equipment. The scaffolds support the growth of conventional intestinal cell lines and primary-derived cells and can be used as platforms for drug screening, disease modeling and microbiome interactions. GUT3D-PLATE will also explore the commercial feasibility of the product by protecting the IPR, analyzing the market, and designing a business plan that provides the roadmap to attract investors. The intestinal 3D culture models will be attractive not only to the biomedical research community, but also to the pharma industry and CROs as they are increasingly investing in tools that better predict drug treatment efficacy and toxicity at early stages of the drug development process. This will reduce significantly the need for animal models and the overall cost, generating a major societal benefit.

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The information about "GUT3D-PLATE" are provided by the European Opendata Portal: CORDIS opendata.

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