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GUT3D-PLATE SIGNED

Ready-to-use cell culture plates for gut 3D models

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 GUT3D-PLATE project word cloud

Explore the words cloud of the GUT3D-PLATE project. It provides you a very rough idea of what is the project "GUT3D-PLATE" about.

intestinal    attract    accurately    substrates    investors    stages    obtain    soft    modeling    predict    attractive    commercial    disease    comiet    significantly    mimic    primary    printing    poc    explore    treatment    models    efforts    conventional    biomedical    feasibility    mimicking    business    tools    cell    community    hydrogel    plan    ease    assays    generating    designing    efficacy    physiology    innovative    3d    protecting    dimensions    toxicity    roadmap    mechanical    generation    screening    pharma    lines    culture    specialized    ready    microbiome    intestine    materials    drug    cros    platforms    tissue    compatible    societal    gut3d    investing    inserts    capacities    morphologies    ipr    plate    crypt    lack    architecture    fabricate    erc    interactions    benefit    customize    analyzing    commercialize    provides    reduce    light    predictive    cells    industry    scaffolds    market    reproducible    device    vitro    devoted    villus    manner    animal    proper    human   

Project "GUT3D-PLATE" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 150˙000.00

Map

 Project objective

3D cell culture models are considered the next-generation in vitro models. Several efforts are being devoted to better mimic human physiology and predict drug efficacy. In case of the intestinal tissue models, the 3D architecture of the intestinal tissue and the soft mechanical properties have been identified as key factors to obtain models with improved predictive capacities. However, there is a lack of low-cost and ease-to-use intestinal tissue models that encompass both elements. In the COMIET ERC project, we developed 3D cell culture scaffolds that accurately mimic the villus and crypt morphologies of the human intestine using soft materials. We used an innovative light-based approach to fabricate hydrogel scaffolds with the proper dimensions and mechanical properties of the tissue, in a reproducible manner. This ERC PoC GUT3D-PLATE will develop further the technology and customize a 3D low cost printing device to be able to fabricate ready-to-commercialize 3D cell culture substrates mimicking the intestinal physiology. These substrates will be provided as ready-to-use cell culture inserts, compatible with conventional assays and without the need of specialized equipment. The scaffolds support the growth of conventional intestinal cell lines and primary-derived cells and can be used as platforms for drug screening, disease modeling and microbiome interactions. GUT3D-PLATE will also explore the commercial feasibility of the product by protecting the IPR, analyzing the market, and designing a business plan that provides the roadmap to attract investors. The intestinal 3D culture models will be attractive not only to the biomedical research community, but also to the pharma industry and CROs as they are increasingly investing in tools that better predict drug treatment efficacy and toxicity at early stages of the drug development process. This will reduce significantly the need for animal models and the overall cost, generating a major societal benefit.

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The information about "GUT3D-PLATE" are provided by the European Opendata Portal: CORDIS opendata.

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