Opendata, web and dolomites

DEFEAT SIGNED

DiseasE-FreE social life without Antibiotics resisTance

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 DEFEAT project word cloud

Explore the words cloud of the DEFEAT project. It provides you a very rough idea of what is the project "DEFEAT" about.

metazoan    bacterial    defensive    societies    adjusting    crops    disease    dates    cocktails    proliferate    termites    sophisticated    bypass    natural    insect    proposing    consecutive    clarify    practices    individual    biology    successfully    hosts    farming    complementary    documenting    invade    sustainability    evolution    counter    defence    virtually    strategically    fundamentally    hallmarks    human    six    insights    antimicrobials    symbiosis    pathogens    group    communities    lines    compounds    agricultural    model    proximate    pioneering    antimicrobial    stark    nothing    organism    gut    cancer    first    diseases    specialised    contributions    essentially    million    forces    allowed    symbiont    organisms    trigger    capitalise    defences    fungus    principles    lived    evolutionary    ways    branches    remarkable    evasion    analogous    rampant    contrast    stewardship    fundamental    suffering    evolve    despite    parasites    fungal    symbionts    preclude    resistance    multilevel    extensive   

Project "DEFEAT" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://www.socialsymbioticevolution.com/
 Total cost 1˙998˙809 €
 EC max contribution 1˙998˙809 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙998˙809.00

Map

 Project objective

The application of antimicrobial compounds produced by hosts or defensive symbionts to counter the effects of diseases has been identified in a number of organisms, but despite extensive studies on their presence, we know essentially nothing about why antimicrobials do not trigger rampant resistance evolution in target parasites. In stark contrast to virtually any other organism, fungus-farming termites have evolved a sophisticated agricultural symbiosis that pre-dates human farming by 30 million years without suffering from specialised diseases. I will capitalise on recent pioneering work in my group on proximate evidence for antimicrobial defences in the termites, their fungal crops, and their complex gut bacterial communities, by proposing to develop the farming symbiosis as a major model to test three novel concepts that may account for the evasion of resistance evolution. First, the antimicrobial compounds may have properties and evolve in ways that preclude resistance evolution in pathogens. Second, resistance is only possible towards individual compounds and not natural antimicrobial cocktails. Third, pathogens can only successfully invade and proliferate if they bypass several consecutive lines of defence, analogous to the six hallmarks of metazoan defence against cancer development. Addressing these concepts will allow fundamental insights into the remarkable success of complementary symbiont contributions to defence, and they will clarify the forces of multilevel natural selection that have allowed long-lived insect societies to evolve sustainability. Documenting and understanding these disease management principles is fundamentally important for several branches of evolutionary biology, and strategically important for adjusting human practices for future antimicrobial stewardship.

 Publications

year authors and title journal last update
List of publications.
2020 Veronica M. Sinotte, Justinn Renelies-Hamilton, Benjamin A. Taylor, Kirsten M. Ellegaard, Panagiotis Sapountzis, Mireille Vasseur-Cognet, Michael Poulsen
Synergies Between Division of Labor and Gut Microbiomes of Social Insects
published pages: , ISSN: 2296-701X, DOI: 10.3389/fevo.2019.00503
Frontiers in Ecology and Evolution 7 2020-02-05
2019 Kasun Bodawatta, Michael Poulsen, Nick Bos
Foraging Macrotermes natalensis Fungus-Growing Termites Avoid a Mycopathogen but Not an Entomopathogen
published pages: 185, ISSN: 2075-4450, DOI: 10.3390/insects10070185
Insects 10/7 2019-12-17
2018 Michael Poulsen, Nick Bos, Sara Kildgaard
Learning from Nature: understanding sustainable antibiotic use
published pages: 176-179, ISSN: , DOI:
Health Europa 7 2019-12-17

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