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CROSS-NEUROD SIGNED

Transferring autonomous and non autonomous cell degeneration 3D models between EU and USA for development of effective therapies for neurodegenerative diseases (ND)

Total Cost €

EC-Contrib. €

Partnership

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CROSS-NEUROD project word cloud

Explore the words cloud of the CROSS-NEUROD project. It provides you a very rough idea of what is the project "CROSS-NEUROD" about.

mutations families cross cooperation grant individual underlying of countries expertise diseases nd therapeutic multidisciplinary collaborative ongoing lack coherent integrate cures prevention treatment active networking largely nds provides disease occurrence scheme spectrum elucidating network strikingly co periods innovative multinational joint integrative coordinated indicating family mini brains italy programs validation 3d mechanisms motor natural public consolidate gene leveraging vitro elucidate opportunity staff previously mnd irses cellular parkinson usa dementia greece molecular patient spinal shared models neurod 2013 7pq health neuron issue successfully bilateral cords progression perform devastating neurodegenerative animal autonomous patients pathogenic worldwide

Project "CROSS-NEUROD" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	693˙000 €
EC max contribution	594˙000 € (86%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2017
Funding Scheme	MSCA-RISE
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2022-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	306˙000.00
2	IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Organization address address: SORANOU EFESIOU 4 city: ATHINA postcode: 115 27 website: www.bioacademy.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	153˙000.00
3	FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO Organization address address: VIA FRANCESCO SFORZA 28 city: MILANO postcode: 20122 website: www.policlinico.mi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	135˙000.00
4	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK Organization address address: AMSTERDAM AVENUE 1210 ROOM city: NEW YORK postcode: 10027 7003 website: www.columbia.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	partner	0.00

Map

Project objective

Neurodegenerative diseases (NDs), such as Dementia, Parkinson’s and motor neuron diseases, are a major and continuously growing worldwide health issue, particularly devastating for patients and their families. Yet, no cures are available, largely due to the lack of knowledge of ND pathogenic mechanisms. Strikingly, co-occurrence of several NDs in the same patient or family, and evidence that mutations in the same gene lead to several NDs are indicating that common molecular pathways are involved across NDs. Elucidating these shared mechanisms could have a major impact for the treatment and the prevention of this spectrum of NDs. Leveraging on our expertise in studying autonomous and non-autonomous mechanisms of NDs, we propose an innovative, multinational and multidisciplinary collaborative research project to perform network analyses across NDs and identify key common underlying mechanisms. The CROSS-NEUROD project is focused on: 1) the development of integrative in vitro 3D disease models (mini-brains, mini-spinal cords, and motor unit) to elucidate common cellular and molecular pathways across NDs; 2) the validation in animal models of the therapeutic targets identified. To achieve these aims we will consolidate research partnerships through staff exchanges and networking activities between 3 European research organizations, two of which from Italy, one from Greece, and a partner, USA. The project is based on a 4 years coordinated joint program of exchanges of researchers for short periods. It has been developed from active bilateral cooperation between individual countries and partners and represents the natural progression of our previously funded and successfully completed EU 7PQ IRSES grant “No-MND” (2013 call). Our ongoing research programs are well supported by funding. The RISE scheme provides a unique opportunity to integrate ongoing collaboration activities into a coherent program addressing an issue of high priority for public health both in EU and USA.

Publications

List of publications.
year	authors and title	journal	last update
2019	Forotti G1, Nizzardo M1, Bucchia M2, Ramirez A2, Trombetta E3, Gatti S4, Bresolin N5, Comi GP5, Corti S6. CSF transplantation of a specific iPSC-derived neural stem cell subpopulation ameliorates the disease phenotype in a mouse model of spinal muscular atrophy with respiratory distress type 1. published pages: , ISSN: 0014-4886, DOI: 10.1016/j.expneurol.2019.113041	Experimental Neurology	2019-10-17
2019	S. CORTI1, I. FARAVELLI1, P. RINCHETTI1, S. MANCINELLI2, L. MAPELLI3, G. FOROTTI4, M. RIZZUTI4, C. CORDIGLIERI5, L. CALANDRIELLO4, S. TAMANINI1, N. BRESOLIN1, G. P. COMI1, S. LODATO2, M. NIZZARDO1 Human 3D cell culture systems to model and elucidate spinal muscular atrophy pathology and treatment* published pages: , ISSN: , DOI:		2019-10-17

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The information about "CROSS-NEUROD" are provided by the European Opendata Portal: CORDIS opendata.