Explore the words cloud of the iPS-ChOp-AF project. It provides you a very rough idea of what is the project "iPS-ChOp-AF" about.
The following table provides information about the project.
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
|Coordinator Country||Israel [IL]|
|Total cost||1˙988˙750 €|
|EC max contribution||1˙988˙750 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-03-01 to 2023-02-28|
Take a look of project's partnership.
|1||TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY||IL (HAIFA)||coordinator||1˙988˙750.00|
'Cardiac arrhythmias are responsible for significant morbidity and mortality. However, the study and treatment of these rhythm disorders have been hampered by the lack of relevant human cardiac tissue models, specifically those reflecting patient/disease-specific abnormalities, by paucity of methods for long-term electrophysiological analysis of the tissue, and by the inability to perform targeted, high-resolution, reversible, and functional perturbations of the system. To address these challenges, we propose to combine human induced pluripotent stem cells (hiPSC) and genome-editing (CRISPR) technologies, developmental biology-inspired differentiating systems that yield chamber-specific heart cells, novel tissue engineering strategies, and emerging concepts from the fields of optogenetics and chemogenetics. The resulting experimental models should represent a paradigm shift in the way we study and treat cardiac arrhythmias. To demonstrate the unique potential of this approach, we plan to focus on atrial fibrillation (AF), the most common arrhythmia. Our specific aims are to: 1. Develop patient/disease-specific hiPSC models of genetic AF and to establish hiPSC differentiation protocols to yield purified atrial cells 2. Utilize the hiPSC-atrial cells and advanced tissue-engineering strategies (hydrogels, 3D printing, decellularization) to establish 2D cell-sheet and 3D tissue models of acquired and inherited AF, in which functional re-entry ('rotors') can be studied 3. Utilize tools from optogenetics (light-sensitive ion channels and pumps) or chemogenetics (ligand-specific engineered receptors) for targeted manipulation of the system, to gain insights into AF pathogenesis and to develop novel therapies 4. Evaluate the developed optogenetic and chemogenetic treatments in animal models of AF The results of this project should provide novel mechanistic insights into AF (and other arrhythmias) and open the road for the development of novel therapeutic paradigms.'
|year||authors and title||journal||last update|
Naim Shaheen, Assad Shiti, Irit Huber, Rami Shinnawi, Gil Arbel, Amira Gepstein, Noga Setter, Idit Goldfracht, Amit Gruber, Snizhanna V. Chorna, Lior Gepstein
Human Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets Expressing Genetically Encoded Voltage Indicator for Pharmacological and Arrhythmia Studies
published pages: 1879-1894, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.04.006
|Stem Cell Reports 10/6||2019-12-16|
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