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iPS-ChOp-AF SIGNED

Combining induced pluripotent stem cells, tissue engineering, optogenetic and chemogenetic concepts for the study and treatment of atrial fibrillation

Total Cost €

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EC-Contrib. €

0

Partnership

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 iPS-ChOp-AF project word cloud

Explore the words cloud of the iPS-ChOp-AF project. It provides you a very rough idea of what is the project "iPS-ChOp-AF" about.

chemogenetics    3d    tools    engineered    channels    optogenetics    editing    reflecting    engineering    cells    hydrogels    inability    developmental    paradigms    cell    resolution    pumps    combine    cardiac    manipulation    therapeutic    chamber    hipsc    tissue    hampered    arrhythmia    pluripotent    patient    acquired    re    plan    purified    entry    mortality    strategies    genome    2d    biology    rotors    printing    differentiation    treat    animal    stem    optogenetic    therapies    functional    heart    atrial    pathogenesis    disorders    fibrillation    arrhythmias    protocols    electrophysiological    paucity    morbidity    inspired    gain    light    yield    shift    differentiating    perturbations    ligand    experimental    sheet    models    responsible    ion    treatments    treatment    sensitive    mechanistic    chemogenetic    road    rhythm    reversible    technologies    crispr    genetic    utilize    abnormalities    paradigm    perform    receptors    disease    lack    human    ing    decellularization    inherited    insights    af   

Project "iPS-ChOp-AF" data sheet

The following table provides information about the project.

Coordinator
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY 

Organization address
address: SENATE BUILDING TECHNION CITY
city: HAIFA
postcode: 32000
website: www.technion.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙988˙750 €
 EC max contribution 1˙988˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY IL (HAIFA) coordinator 1˙988˙750.00

Map

 Project objective

'Cardiac arrhythmias are responsible for significant morbidity and mortality. However, the study and treatment of these rhythm disorders have been hampered by the lack of relevant human cardiac tissue models, specifically those reflecting patient/disease-specific abnormalities, by paucity of methods for long-term electrophysiological analysis of the tissue, and by the inability to perform targeted, high-resolution, reversible, and functional perturbations of the system. To address these challenges, we propose to combine human induced pluripotent stem cells (hiPSC) and genome-editing (CRISPR) technologies, developmental biology-inspired differentiating systems that yield chamber-specific heart cells, novel tissue engineering strategies, and emerging concepts from the fields of optogenetics and chemogenetics. The resulting experimental models should represent a paradigm shift in the way we study and treat cardiac arrhythmias. To demonstrate the unique potential of this approach, we plan to focus on atrial fibrillation (AF), the most common arrhythmia. Our specific aims are to: 1. Develop patient/disease-specific hiPSC models of genetic AF and to establish hiPSC differentiation protocols to yield purified atrial cells 2. Utilize the hiPSC-atrial cells and advanced tissue-engineering strategies (hydrogels, 3D printing, decellularization) to establish 2D cell-sheet and 3D tissue models of acquired and inherited AF, in which functional re-entry ('rotors') can be studied 3. Utilize tools from optogenetics (light-sensitive ion channels and pumps) or chemogenetics (ligand-specific engineered receptors) for targeted manipulation of the system, to gain insights into AF pathogenesis and to develop novel therapies 4. Evaluate the developed optogenetic and chemogenetic treatments in animal models of AF The results of this project should provide novel mechanistic insights into AF (and other arrhythmias) and open the road for the development of novel therapeutic paradigms.'

 Publications

year authors and title journal last update
List of publications.
2018 Naim Shaheen, Assad Shiti, Irit Huber, Rami Shinnawi, Gil Arbel, Amira Gepstein, Noga Setter, Idit Goldfracht, Amit Gruber, Snizhanna V. Chorna, Lior Gepstein
Human Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets Expressing Genetically Encoded Voltage Indicator for Pharmacological and Arrhythmia Studies
published pages: 1879-1894, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.04.006
Stem Cell Reports 10/6 2019-12-16

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