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QuanTII SIGNED

Quantitative T cell Immunology and Immunotherapy

Total Cost €

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EC-Contrib. €

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Partnership

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Project "QuanTII" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 3˙923˙652 €
 EC max contribution 3˙923˙652 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 819˙863.00
2    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 510˙748.00
3    BAYER AKTIENGESELLSCHAFT DE (Leverkusen) participant 498˙432.00
4    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) participant 498˙432.00
5    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 273˙287.00
6    MEDIMMUNE LIMITED UK (CAMBRIDGE) participant 273˙287.00
7    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) participant 265˙674.00
8    NATIONAL UNIVERSITY OF IRELAND MAYNOOTH IE (Maynooth) participant 265˙674.00
9    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 262˙875.00
10    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 255˙374.00

Map

 Project objective

Health and disease are regulated, to a large extent, by our immune system. The immune system not only protects the body from infectious disease, but is involved in a number of conditions of increasing incidence and morbidity, such as diabetes, rheumatoid arthritis, inflammatory bowel disease and allergies. In cancer, the immune system can be both cause and cure; it contributes to chronic inflammation that promotes tumour development, but it can also provide the ultimate weapon against metastatic disease. Thus, the development of ways to harness, direct or restrain immune responses has great potential for enhancing human health. Understanding the mechanisms that control the abundance of different lymphocyte (a type of white blood cell) subsets is key to therapeutically targeting immune responses. Ultimately, this understanding must be sought in quantitative terms, explaining how the rates of cell proliferation, differentiation, survival and death are determined by molecular mechanisms and cellular interactions. Current immunological research is beginning to combine experimental approaches with mathematical analysis to quantitate immune dynamics. A severe obstacle to more rapid progress in this area is the lack of appropriately trained scientists. In this ETN, European scientists, with a rich track record in collaborative research and training, have come together to deliver a highly collaborative, multidisciplinary and intersectoral research training programme for 15 early stage researchers (ESRs) in Quantitative T cell Immunology and Immunotherapy (QuanTII).

 Publications

year authors and title journal last update
List of publications.
2019 Jung‐Hyun Park, Adam T. Waickman, Joseph Reynolds, Mario Castro, Carmen Molina‐París
IL7 receptor signaling in T cells: A mathematical modeling perspective
published pages: , ISSN: 1939-5094, DOI: 10.1002/wsbm.1447
Wiley Interdisciplinary Reviews: Systems Biology and Medicine 11/5 2020-04-11
2019 Luis de la Higuera, Martín López-García, Mario Castro, Niloufar Abourashchi, Grant Lythe, Carmen Molina-París
Fate of a Naive T Cell: A Stochastic Journey
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00194
Frontiers in Immunology 10 2020-04-11
2018 Thomas Höfer, Hans-Reimer Rodewald
Differentiation-based model of hematopoietic stem cell functions and lineage pathways
published pages: 1106-1113, ISSN: 0006-4971, DOI: 10.1182/blood-2018-03-791517
Blood 132/11 2020-04-11

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