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POLYTHEA SIGNED

Design and photo-optimization of Photosensitizer for Human Health and Food security applications or “how light can save lives”

Total Cost €

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EC-Contrib. €

0

Partnership

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 POLYTHEA project word cloud

Explore the words cloud of the POLYTHEA project. It provides you a very rough idea of what is the project "POLYTHEA" about.

activating    effect    absence    network    ps    created    overcome    types    prosthetic    proposes    pdt    sterilizing    skin    prevention    gram    active    inflammatory    anti    excitation    treatments    unfortunately    valuable    surfaces    barriers    immune    oxygen    ros    tetrapyrrolic    infections    photophysical    fight    structure    death    excitable    joint    parallel    ejd    practical    supports    induce    phd    sectorial    therapy    chemo    toxicity    self    countries    efficacy    inspired    first    bio    academic    largely    photodynamic    photo    employees    scientific    gathering    utmost    cancer    improvement    carriers    background    eradication    industry    pact    expectations    good    biofilms    aid    health    fragmented    meet    bactericidal    bacterial    compounds    solving    cell    esrs    biological    inter    molecules    events    human    reactive    multidisciplinary    photosensitizers    species    tumour    candidates    disease    bandages    security    antimicrobial    drug    innovative    food    light    polythea    training    secondments    microbial    doctorate   

Project "POLYTHEA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LIMOGES 

Organization address
address: François Mitterrand 33
city: Limoges
postcode: 87032
website: www.unilim.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙548˙256 €
 EC max contribution 2˙548˙256 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-EJD
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LIMOGES FR (Limoges) coordinator 525˙751.00
2    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) participant 797˙023.00
3    UNIVERSITE DE NEUCHATEL CH (NEUCHATEL) participant 265˙226.00
4    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 255˙374.00
5    BIOEMISSION TECHNOLOGY SOLUTIONS IKE EL (ATHINA) participant 242˙386.00
6    UNIVERSIDADE DE COIMBRA PT (COIMBRA) participant 238˙356.00
7    POLITECHNIKA WROCLAWSKA PL (WROCLAW) participant 224˙137.00

Map

 Project objective

The development of active compounds that can efficiently fight microbial infections and cancer are of utmost importance for food security and human health, two main challenges for Europe. Tetrapyrrolic photosensitizers (PS) are good candidates to meet these expectations. These photo-excitable molecules induce cell death via the formation of oxygen reactive species (ROS) and present very low toxicity in the absence of light. They are already used in photodynamic therapy (PDT) for cancer or skin disease treatments or in photo-antimicrobial chemo-therapy (PACT). Unfortunately, the research and training are still largely fragmented in this field in Europe. Some scientific barriers have to be overcome to increase their efficacy, e.g. improvement of the excitation pathways, ROS production, specific cell targeting, Gram (-) bactericidal effect and prevention and/or eradication of biofilms. That is why the EJD Polythea project aims developing an integrated and multidisciplinary approach of PDT through the implementation of 10 PhD research projects. The Polythea consortium proposes to develop (i) new tetrapyrrolic PS for various types of PDT including anti-cancer, anti-bacterial, anti-inflammatory and immune-activating application, improving their photophysical and biological properties; and (ii) innovative bio-inspired drug carriers or supports. In parallel, a joint doctorate structure gathering 5 countries will be created and a multidisciplinary and inter-sectorial training programme will be implemented through network events and secondments to non-academic partners. It will provide a common background on PDT to the ESRs and make them more valuable employees, effective at problem solving. Practical applications should come out of this project such as first aid bandages, new skin/anti-tumour treatments, self-sterilizing surfaces for food industry or prosthetic devices.

 Publications

year authors and title journal last update
List of publications.
2020 Dáire J. Gibbons, Aram Farawar, Paul Mazzella, Stéphanie Leroy-Lhez, René M. Williams
Making Triplets from Photo-generated Charges: Observations, Mechanisms and Theory
published pages: , ISSN: 1474-905X, DOI: 10.1039/c9pp00399a
Photochemical & Photobiological Sciences 2020-02-27
2020 Nidia Maldonado-Carmona, Tan Sothea Ouk, Mário J. F. Calvete, Mariette M. Pereira, Nicolas Villandier, Stéphanie Leroy-Lhez
Conjugating biomaterials with photosensitizers: advances and perspectives for Photodynamic Antimicrobial Chemotherapy
published pages: , ISSN: 1474-905X, DOI: 10.1039/c9pp00398c
Photochemical & Photobiological Sciences 2020-02-27
2019 Arno Wiehe, Jessica M. O\'Brien, Mathias O. Senge
Trends and targets in antiviral phototherapy
published pages: 2565-2612, ISSN: 1474-905X, DOI: 10.1039/c9pp00211a
Photochemical & Photobiological Sciences 18/11 2020-02-27
2019 Leszek M. Mazur, Thomas Roland, Stephanie Leroy-Lhez, Vincent Sol, Marek Samoc, Ifor D.W. Samuel, Katarzyna Matczyszyn
Efficient Singlet Oxygen Photogeneration by Zinc Porphyrin Dimers upon One- and Two-Photon Excitation
published pages: 4271-4277, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.8b12561
The Journal of Physical Chemistry B 123/19 2020-02-27
2019 Manuel Gallardo-Villagrán, David Yannick Leger, Bertrand Liagre, Bruno Therrien
Photosensitizers Used in the Photodynamic Therapy of Rheumatoid Arthritis
published pages: 3339, ISSN: 1422-0067, DOI: 10.3390/ijms20133339
International Journal of Molecular Sciences 20/13 2020-02-27
2019 Benjamin F Hohlfeld, Keith J Flanagan, Nora Kulak, Mathias O. Senge, Mathias Christmann, Arno Wiehe
Synthesis of Porphyrinoids, BODIPYs and (Dipyrrinato)ruthenium(II) Complexes from Pre-functionalized Dipyrromethanes
published pages: , ISSN: 1434-193X, DOI: 10.1002/ejoc.201900530
European Journal of Organic Chemistry 2020-02-27
2018 Claudia S. Gutsche, Susanna Gräfe, Burkhard Gitter, Keith J. Flanagan, Mathias O. Senge, Nora Kulak, Arno Wiehe
Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives
published pages: , ISSN: 1477-9226, DOI: 10.1039/C8DT03059F
Dalton Transactions 2020-02-27
2018 Susan Callaghan, Mathias O. Senge
The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy
published pages: , ISSN: 1474-905X, DOI: 10.1039/C8PP00008E
Photochemical & Photobiological Sciences 2020-02-27
2018 Guillaume Marchand, Claude A. Calliste, René M. Williams, Charlotte McLure, Stéphanie Leroy-Lhez, Nicolas Villandier
Acetylated Lignins: A Potential Bio-Sourced Photosensitizer
published pages: 5512-5516, ISSN: 2365-6549, DOI: 10.1002/slct.201801039
ChemistrySelect 3/20 2020-02-27
2018 Bruno Therrien
The Role of the Second Coordination Sphere in the Biological Activity of Arene Ruthenium Metalla-Assemblies
published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2018.00602
Frontiers in Chemistry 6 2020-02-27
2019 Bhavya Khurana, Piotr Gierlich, Alina Meindl, Lígia C. Gomes-da-Silva, Mathias O. Senge
Hydrogels: soft matters in photomedicine
published pages: , ISSN: 1474-905X, DOI: 10.1039/c9pp00221a
Photochemical & Photobiological Sciences 2019 2020-02-27
2019 Claire Donohoe, Mathias O. Senge, Luís G. Arnaut, Lígia C. Gomes-da-Silva
Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity
published pages: , ISSN: 0304-419X, DOI: 10.1016/j.bbcan.2019.07.003
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2020-02-27

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