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POLYTHEA SIGNED

Design and photo-optimization of Photosensitizer for Human Health and Food security applications or “how light can save lives”

Total Cost €

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EC-Contrib. €

0

Partnership

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 POLYTHEA project word cloud

Explore the words cloud of the POLYTHEA project. It provides you a very rough idea of what is the project "POLYTHEA" about.

health    inflammatory    bactericidal    supports    prevention    compounds    treatments    effect    fight    carriers    overcome    scientific    utmost    valuable    industry    academic    bio    fragmented    multidisciplinary    absence    oxygen    death    tumour    proposes    network    active    biofilms    reactive    solving    pact    countries    excitable    barriers    parallel    food    excitation    photosensitizers    activating    innovative    created    unfortunately    improvement    bandages    aid    species    meet    types    disease    skin    doctorate    phd    sterilizing    secondments    expectations    pdt    security    sectorial    esrs    infections    cell    events    ps    good    biological    self    polythea    inspired    human    cancer    background    photophysical    microbial    largely    light    photo    candidates    toxicity    bacterial    employees    structure    ros    first    antimicrobial    therapy    drug    chemo    surfaces    efficacy    molecules    training    practical    photodynamic    anti    induce    gram    joint    ejd    tetrapyrrolic    inter    gathering    prosthetic    immune    eradication   

Project "POLYTHEA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LIMOGES 

Organization address
address: François Mitterrand 33
city: Limoges
postcode: 87032
website: www.unilim.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙548˙256 €
 EC max contribution 2˙548˙256 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-EJD
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LIMOGES FR (Limoges) coordinator 525˙751.00
2    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) participant 797˙023.00
3    UNIVERSITE DE NEUCHATEL CH (NEUCHATEL) participant 265˙226.00
4    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 255˙374.00
5    BIOEMISSION TECHNOLOGY SOLUTIONS IKE EL (ATHINA) participant 242˙386.00
6    UNIVERSIDADE DE COIMBRA PT (COIMBRA) participant 238˙356.00
7    POLITECHNIKA WROCLAWSKA PL (WROCLAW) participant 224˙137.00

Map

 Project objective

The development of active compounds that can efficiently fight microbial infections and cancer are of utmost importance for food security and human health, two main challenges for Europe. Tetrapyrrolic photosensitizers (PS) are good candidates to meet these expectations. These photo-excitable molecules induce cell death via the formation of oxygen reactive species (ROS) and present very low toxicity in the absence of light. They are already used in photodynamic therapy (PDT) for cancer or skin disease treatments or in photo-antimicrobial chemo-therapy (PACT). Unfortunately, the research and training are still largely fragmented in this field in Europe. Some scientific barriers have to be overcome to increase their efficacy, e.g. improvement of the excitation pathways, ROS production, specific cell targeting, Gram (-) bactericidal effect and prevention and/or eradication of biofilms. That is why the EJD Polythea project aims developing an integrated and multidisciplinary approach of PDT through the implementation of 10 PhD research projects. The Polythea consortium proposes to develop (i) new tetrapyrrolic PS for various types of PDT including anti-cancer, anti-bacterial, anti-inflammatory and immune-activating application, improving their photophysical and biological properties; and (ii) innovative bio-inspired drug carriers or supports. In parallel, a joint doctorate structure gathering 5 countries will be created and a multidisciplinary and inter-sectorial training programme will be implemented through network events and secondments to non-academic partners. It will provide a common background on PDT to the ESRs and make them more valuable employees, effective at problem solving. Practical applications should come out of this project such as first aid bandages, new skin/anti-tumour treatments, self-sterilizing surfaces for food industry or prosthetic devices.

 Publications

year authors and title journal last update
List of publications.
2020 Dáire J. Gibbons, Aram Farawar, Paul Mazzella, Stéphanie Leroy-Lhez, René M. Williams
Making Triplets from Photo-generated Charges: Observations, Mechanisms and Theory
published pages: , ISSN: 1474-905X, DOI: 10.1039/c9pp00399a
Photochemical & Photobiological Sciences 2020-02-27
2020 Nidia Maldonado-Carmona, Tan Sothea Ouk, Mário J. F. Calvete, Mariette M. Pereira, Nicolas Villandier, Stéphanie Leroy-Lhez
Conjugating biomaterials with photosensitizers: advances and perspectives for Photodynamic Antimicrobial Chemotherapy
published pages: , ISSN: 1474-905X, DOI: 10.1039/c9pp00398c
Photochemical & Photobiological Sciences 2020-02-27
2019 Arno Wiehe, Jessica M. O\'Brien, Mathias O. Senge
Trends and targets in antiviral phototherapy
published pages: 2565-2612, ISSN: 1474-905X, DOI: 10.1039/c9pp00211a
Photochemical & Photobiological Sciences 18/11 2020-02-27
2019 Leszek M. Mazur, Thomas Roland, Stephanie Leroy-Lhez, Vincent Sol, Marek Samoc, Ifor D.W. Samuel, Katarzyna Matczyszyn
Efficient Singlet Oxygen Photogeneration by Zinc Porphyrin Dimers upon One- and Two-Photon Excitation
published pages: 4271-4277, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.8b12561
The Journal of Physical Chemistry B 123/19 2020-02-27
2019 Manuel Gallardo-Villagrán, David Yannick Leger, Bertrand Liagre, Bruno Therrien
Photosensitizers Used in the Photodynamic Therapy of Rheumatoid Arthritis
published pages: 3339, ISSN: 1422-0067, DOI: 10.3390/ijms20133339
International Journal of Molecular Sciences 20/13 2020-02-27
2019 Benjamin F Hohlfeld, Keith J Flanagan, Nora Kulak, Mathias O. Senge, Mathias Christmann, Arno Wiehe
Synthesis of Porphyrinoids, BODIPYs and (Dipyrrinato)ruthenium(II) Complexes from Pre-functionalized Dipyrromethanes
published pages: , ISSN: 1434-193X, DOI: 10.1002/ejoc.201900530
European Journal of Organic Chemistry 2020-02-27
2018 Claudia S. Gutsche, Susanna Gräfe, Burkhard Gitter, Keith J. Flanagan, Mathias O. Senge, Nora Kulak, Arno Wiehe
Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives
published pages: , ISSN: 1477-9226, DOI: 10.1039/C8DT03059F
Dalton Transactions 2020-02-27
2018 Susan Callaghan, Mathias O. Senge
The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy
published pages: , ISSN: 1474-905X, DOI: 10.1039/C8PP00008E
Photochemical & Photobiological Sciences 2020-02-27
2018 Guillaume Marchand, Claude A. Calliste, René M. Williams, Charlotte McLure, Stéphanie Leroy-Lhez, Nicolas Villandier
Acetylated Lignins: A Potential Bio-Sourced Photosensitizer
published pages: 5512-5516, ISSN: 2365-6549, DOI: 10.1002/slct.201801039
ChemistrySelect 3/20 2020-02-27
2018 Bruno Therrien
The Role of the Second Coordination Sphere in the Biological Activity of Arene Ruthenium Metalla-Assemblies
published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2018.00602
Frontiers in Chemistry 6 2020-02-27
2019 Bhavya Khurana, Piotr Gierlich, Alina Meindl, Lígia C. Gomes-da-Silva, Mathias O. Senge
Hydrogels: soft matters in photomedicine
published pages: , ISSN: 1474-905X, DOI: 10.1039/c9pp00221a
Photochemical & Photobiological Sciences 2019 2020-02-27
2019 Claire Donohoe, Mathias O. Senge, Luís G. Arnaut, Lígia C. Gomes-da-Silva
Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity
published pages: , ISSN: 0304-419X, DOI: 10.1016/j.bbcan.2019.07.003
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2020-02-27

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