Explore the words cloud of the AutoClean project. It provides you a very rough idea of what is the project "AutoClean" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||1˙955˙666 €|
|EC max contribution||1˙955˙666 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-06-01 to 2023-05-31|
Take a look of project's partnership.
|1||UNIVERSITAETSKLINIKUM FREIBURG||DE (FREIBURG)||coordinator||1˙955˙666.00|
Autophagy, a lysosomal degradation pathway in which the cell digests its own components, is an essential biological pathway that promotes organismal health and longevity and helps combat cancer and neurodegenerative diseases. Accordingly, the 2016 Nobel Prize in Physiology or Medicine was awarded for research in autophagy. Although autophagy has been extensively studied from yeast to mammals, the molecular events that underlie its induction and progression remain elusive. A highly conserved protein kinase, Atg1, plays a unique and essential role in initiating autophagy, yet despite this pivotal importance it has taken over twenty years for its first downstream target to be discovered. However, whilst our identification of the autophagy related membrane protein Atg9 as the first Atg1 substrate is an important advance, the molecular mechanisms that enable the extensive remodelling of cellular membranes that occurs during autophagy is still completely undefined. A detailed knowledge of the inputs and outputs of the Atg1 kinase will enable us to provide a definitive mechanistic understanding of autophagy. We have devised a novel permeabilized cell assay that reconstitutes the pathway in vitro, allowing us to recapitulate key steps in the autophagic process and thereby determine how the individual steps that lead up to autophagy are controlled. We will use this system to dissect the functional role of Atg1 kinase in autophagosome-vacuole fusion (Objective 1), and to determine the origin of the autophagic membrane and the role of Atg1 in expanding these (Objective 2). To reveal how Atg1/ULK1 kinase is activated in mammalian cells, we will apply the unique and carefully tailored synthetic in vivo approaches that we have recently developed (Objective 3). By focusing on the activation of the Atg1 kinase and the molecular events that it executes, we will be able to explain its central role in regulating the autophagic process and define the mechanistic steps in the pathway.
|year||authors and title||journal||last update|
Levent Bas, Daniel Papinski, Claudine Kraft
Ykt6 mediates autophagosome-vacuole fusion
published pages: e1526006, ISSN: 2372-3556, DOI: 10.1080/23723556.2018.1526006
|Molecular & Cellular Oncology 5/6||2020-01-30|
David M. Hollenstein, RubÃ©n GÃ³mez-SÃ¡nchez, Akif Ciftci, Franziska Kriegenburg, Muriel Mari, Raffaela Torggler, Mariya Licheva, Fulvio Reggiori, Claudine Kraft
Vac8 spatially confines autophagosome formation at the vacuole in S. cerevisiae
published pages: jcs235002, ISSN: 0021-9533, DOI: 10.1242/jcs.235002
|Journal of Cell Science 132/22||2020-01-30|
Levent Bas, Daniel Papinski, Mariya Licheva, Raffaela Torggler, Sabrina Rohringer, Martina Schuschnig, Claudine Kraft
Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosomeâ€“vacuole fusion
published pages: 3656-3669, ISSN: 0021-9525, DOI: 10.1083/jcb.201804028
|The Journal of Cell Biology 217/10||2020-01-30|
Daniel Poveda-Huertes, Stanka Matic, Adinarayana Marada, Lukas Habernig, Mariya Licheva, Lisa Myketin, Ralf Gilsbach, Sergi Tosal-Castano, Daniel Papinski, Patrycja Mulica, Oliver Kretz, Cansu KÃ¼cÃ¼kkÃ¶se, Asli Aras Taskin, Lutz Hein, Claudine Kraft, Sabrina BÃ¼ttner, Chris Meisinger, F.-Nora VÃ¶gtle
An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates
published pages: 180-188.e9, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.09.026
|Molecular Cell 77/1||2020-01-30|
Claudine Kraft, Patricia Boya, Patrice Codogno, Zvulun Elazar, Eeva-Liisa Eskelinen, Judith FarrÃ©s, Vladimir Kirkin, Heinz Jungbluth, Ana Martinez, Ole Pless, Charlotte Primard, Tassula Proikas-Cezanne, Anne Simonsen, Fulvio Reggiori
Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy
published pages: 347-351, ISSN: 1554-8627, DOI: 10.1080/15548627.2018.1515532
Franziska Kriegenburg, Levent Bas, Jieqiong Gao, Christian Ungermann, Claudine Kraft
The multi-functional SNARE protein Ykt6 in autophagosomal fusion processes
published pages: 639-651, ISSN: 1538-4101, DOI: 10.1080/15384101.2019.1580488
|Cell Cycle 18/6-7||2020-01-30|
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The information about "AUTOCLEAN" are provided by the European Opendata Portal: CORDIS opendata.