EU H2020 Project "SPLINTER (Signaling of plant intracellular immune receptors)": description, partecipants, costs and EC-fundings

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SPLINTER project word cloud

Explore the words cloud of the SPLINTER project. It provides you a very rough idea of what is the project "SPLINTER" about.

family opportunity tomato context requirement career resistance home food compromised arises candidates temperature domains social crop heart full self lacking receptor containing independently bacteria plant naturally economic stress signaling lower phytopathogenic solanacearum downstream nod strategy warming security mid critical sufficient global concerning deployment country terminal threat vegetable preliminary hence canonical potent receptors genetic ralstonia lived pathogen devastating nlrs stresses function worldwide hypothesis data unlike manipulating world returning researcher mainly decipher immune model encoded disease recognition indicate arabidopsis environmental nlr length diseases elevated splinter source act risk crops intracellular genes occurring breakdown activate truncated

Project "SPLINTER" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 website: www.inra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	https://www.researchgate.net/profile/Maud_Bernoux
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-RI
Starting year	2018
Duration (year-month-day)	from 2018-03-05 to 2020-09-05

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT	FR (PARIS CEDEX 07)	coordinator	185˙076.00

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT

FR (PARIS CEDEX 07)

coordinator

185˙076.00

Project objective

Plant diseases are an economic, environmental and social threat affecting crop production worldwide. Effective plant disease resistance is a critical requirement to maintain world food security. Deployment of resistance (R) genes in crops is currently the most effective strategy for genetic control of disease. However, this type of resistance can be short-lived and is often affected by environmental stresses such as elevated temperature, which is highly concerning in the context of global warming. The proposed research aims to decipher the signaling function of intracellular plant immune receptors of the NOD-like receptor (NLR) family encoded by canonical and non-canonical (truncated) R genes. The opportunity at the heart of this project arises from the finding that N-terminal domains of NLRs act as potent signaling domains that are self-sufficient to activate immune responses independently of pathogen recognition and preliminary data indicate that this signaling activity is not compromised at elevated temperature (unlike full length NLRs). Hence, manipulating signaling downstream of pathogen recognition may lower the risk of resistance breakdown and provide a source of disease resistance adapted to global warming. Naturally occurring truncated NLRs lacking some of the canonical domains but containing N-terminal signaling domains are promising candidates to investigate this hypothesis. “SPLINTER” will focus on the signaling function of canonical and non-canonical NLRs in the major vegetable crop tomato, and the model plant Arabidopsis, mainly in response to the devastating phytopathogenic bacteria Ralstonia solanacearum and under temperature stress. This project will also establish a long-term research path for an early-mid career researcher returning to her home country.

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