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SaRNAReg SIGNED

Staphylococcus aureus sRNA targetomes and regulatory networks involved in fast adaptive responses: structure, mechanisms and dynamics

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SaRNAReg project word cloud

Explore the words cloud of the SaRNAReg project. It provides you a very rough idea of what is the project "SaRNAReg" about.

identification    ribosome    scrutiny    multidrug    population    hence    regulation    commercially    regulators    aureus    unravel    gene    mechanisms    nosocomial    compounds    rna    contain    possibility    human    unprecedented    deepest    roles    dynamics    strains    srnas    microbiome    antimicrobial    virulence    obtain    transcriptional    small    exploited    regulate    publications    monitor    fight    responsible    resistant    drug    environmental    infections    combination    severe    physiology    profiling    affinity    acquired    stress    strategies    staphylococcus    opportunistic    adapt    action    patenting    biological    behavior    purification    mediated    unexpected    sequencing    synthesis    biochemical    coupled    community    ms2    networks    multiple    bacterium    targetomes    influence    genetic    technologies    mysteries    innovative    questions    rnas    perspectives    expression    srna    regulated    dependent    pave    visualize    monoclonal    individual    stresses    licensing    draw    single    pathogen    cell    elucidate    techniques    regulatory   

Project "SaRNAReg" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-06-04   to  2020-06-03

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Staphylococcus aureus is an opportunistic human pathogen responsible for severe nosocomial and community acquired infections. S. aureus has evolved a large number of strategies to regulate the synthesis of multiple virulence factors including the use of small regulatory RNAs (sRNAs). These sRNAs in combination with transcriptional regulators adapt cell growth in response to various stresses and environmental conditions. Hence, the identification of sRNAs regulatory networks is of crucial importance in the fight against emerging multidrug resistant strains. Using recent and innovative technologies (i.e. MS2-affinity purification coupled with RNA sequencing and ribosome profiling), we will investigate biological roles of sRNAs, elucidate their targetomes, and their mechanisms of action that was not possible to obtain with classical genetic and biochemical approaches. This project is aimed to draw comprehensive sRNA regulatory networks, which may contain many new targets regulated by unexpected mechanisms and unravel the deepest mysteries in sRNA field in this major opportunistic pathogen. Finally, sRNA-mediated regulation dynamics will be analyzed with unprecedented scrutiny in single-cell studies. The recent development of techniques to visualize RNA and to monitor gene expression in individual bacterium, offer the possibility to address specific questions related to the dynamics of sRNA regulation. Proposed single cell studies will be crucial to investigate the dynamics of sRNAs-dependent regulation, but also to monitor its impact on a monoclonal population behavior in response to a particular stress. Such analysis will open long term perspectives such as to monitor the influence of the microbiome on S. aureus physiology. It should also pave the way to the identification of novel targets for drug design and to the development of novel antimicrobial compounds. New findings will be commercially exploited through patenting and licensing before publications.

 Publications

year authors and title journal last update
List of publications.
2020 Emma Desgranges, Isabelle Caldelari, Stefano Marzi, David Lalaouna
Navigation through the twists and turns of RNA sequencing technologies: Application to bacterial regulatory RNAs
published pages: 194506, ISSN: 1874-9399, DOI: 10.1016/j.bbagrm.2020.194506
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1863/3 2020-03-05
2019 Jens Georg, David Lalaouna, Shengwei Hou, Steffen C. Lott, Isabelle Caldelari, Stefano Marzi, Wolfgang R. Hess, Pascale Romby
The power of cooperation: Experimental and computational approaches in the functional characterization of bacterial sRNAs
published pages: , ISSN: 0950-382X, DOI: 10.1111/mmi.14420
Molecular Microbiology 2020-02-13
2019 David Lalaouna, Jessica Baude, Zongfu Wu, Arnaud Tomasini, Johana Chicher, Stefano Marzi, François Vandenesch, Pascale Romby, Isabelle Caldelari, Karen Moreau
RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation
published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gkz728
Nucleic Acids Research 2019-09-05

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The information about "SARNAREG" are provided by the European Opendata Portal: CORDIS opendata.

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