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MyelinPlasticity SIGNED

Neuronal regulation of CNS myelin plasticity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MyelinPlasticity" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙729 €
 EC max contribution 1˙999˙729 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙999˙729.00

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 Project objective

Myelin is essential for normal brain function, as it provides fast signal transmission, promotes synchronisation of neuronal signals and helps to maintain neuronal function. Alterations in myelination are increasingly being implicated as a mechanism for sensory-motor learning. The importance of myelin becomes evident in diseases, such as multiple sclerosis (MS), where myelin damage causes cognitive and motor disability. Moreover, recent studies have highlighted the contribution of myelin to many diseases that were previously considered to be ‘neuronal’, such as dementia, schizophrenia, autism and bipolar disorder. Despite the profound importance of myelin, there are serious deficits in our understanding of how myelination is regulated and to what extent myelin is plastic; which are impediments for understanding both the functional connectivity of the central nervous system (CNS) and white matter disease.

We, and others, have shown that myelination can be regulated by neuronal activity, thus I hypothesize that neuronal activity is a driver of myelin plasticity, similar to synaptic plasticity. By using an innovative approach combining electrophysiology, optogenetics, pharmacogenetics, imaging, transgenic animals, behavioural tests, and in vitro and in vivo models of myelination, this research programme will determine mechanisms that mediate neuronal activity dependent myelination, establish to what extent myelin changes occur with learning and identify to what extent myelin is plastic.

The outcome of this proposal will break new ground in our understanding of myelin plasticity, and has the potential to provide novel therapeutic strategies for myelin regeneration in white matter diseases such as MS.

 Publications

year authors and title journal last update
List of publications.
2019 Wanyi Jia, Yasmine Kamen, Helena Pivonkova, Ragnhildur T. Káradóttir
Neuronal activity-dependent myelin repair after stroke
published pages: 139-144, ISSN: 0304-3940, DOI: 10.1016/j.neulet.2019.03.005
Neuroscience Letters 703 2020-03-05
2019 Sonia Olivia Spitzer, Sergey Sitnikov, Yasmine Kamen, Kimberley Anne Evans, Deborah Kronenberg-Versteeg, Sabine Dietmann, Omar de Faria, Sylvia Agathou, Ragnhildur Thóra Káradóttir
Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age
published pages: 459-471.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.12.020
Neuron 101/3 2020-03-05

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