Opendata, web and dolomites

3DBrainStrom SIGNED

Brain metastases: Deciphering tumor-stroma interactions in three dimensions for the rational design of nanomedicines

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 3DBrainStrom project word cloud

Explore the words cloud of the 3DBrainStrom project. It provides you a very rough idea of what is the project "3DBrainStrom" about.

tumor    molecular    insights    plastic    3d    rigid    poor    vast    accumulate    prevention    cells    fronts    printed    functional    paradigm    consequently    flowing    elicit    drug    experimental    extracellular    mechanical    grown    outcome    stroma    compartments    vivo    pave    shift    disease    prediction    constitute    rates    clinical    breakthroughs    preclinical    therapeutic    metastatic    followed    revolutionizing    metastases    cellular    physio    patient    lacking    plates    selectively    antitumor    nowadays    therapies    brain    containing    generating    crosstalk    mice    bridge    anticancer    2d    cancer    prevent    signaling    regression    polymeric    immune    intervention    despite    micrometastases    libraries    settings    evaluation    perception    responsiveness    fundamental    patients    materialize    survival    colonization    precision    macrometastatic    therapeutics    treat    immunodeficient    translation    matrix    clinically    hemodynamics    nanomedicines    capture    drivers    discoveries    tissue    translational    discovery    nanocarriers    hurdle    vessels    nano    models    performed    vaccines    gap    human    serum    tumors   

Project "3DBrainStrom" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙353˙125 €
 EC max contribution 2˙353˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 2˙353˙125.00

Map

 Project objective

Brain metastases represent a major therapeutic challenge. Despite significant breakthroughs in targeted therapies, survival rates of patients with brain metastases remain poor. Nowadays, discovery, development and evaluation of new therapies are performed on human cancer cells grown in 2D on rigid plastic plates followed by in vivo testing in immunodeficient mice. These experimental settings are lacking and constitute a fundamental hurdle for the translation of preclinical discoveries into clinical practice. We propose to establish 3D-printed models of brain metastases (Aim 1), which include brain extracellular matrix, stroma and serum containing immune cells flowing in functional tumor vessels. Our unique models better capture the clinical physio-mechanical tissue properties, signaling pathways, hemodynamics and drug responsiveness. Using our 3D-printed models, we aim to develop two new fronts for identifying novel clinically-relevant molecular drivers (Aim 2) followed by the development of precision nanomedicines (Aim 3). We will exploit our vast experience in anticancer nanomedicines to design three therapeutic approaches that target various cellular compartments involved in brain metastases: 1) Prevention of brain metastatic colonization using targeted nano-vaccines, which elicit antitumor immune response; 2) Intervention of tumor-brain stroma cells crosstalk when brain micrometastases establish; 3) Regression of macrometastatic disease by selectively targeting tumor cells. These approaches will materialize using our libraries of polymeric nanocarriers that selectively accumulate in tumors. This project will result in a paradigm shift by generating new preclinical cancer models that will bridge the translational gap in cancer therapeutics. The insights and tumor-stroma-targeted nanomedicines developed here will pave the way for prediction of patient outcome, revolutionizing our perception of tumor modelling and consequently the way we prevent and treat cancer.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "3DBRAINSTROM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "3DBRAINSTROM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More  

RODRESET (2019)

Development of novel optogenetic approaches for improving vision in macular degeneration

Read More