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3DBrainStrom SIGNED

Brain metastases: Deciphering tumor-stroma interactions in three dimensions for the rational design of nanomedicines

Total Cost €

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EC-Contrib. €

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Partnership

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 3DBrainStrom project word cloud

Explore the words cloud of the 3DBrainStrom project. It provides you a very rough idea of what is the project "3DBrainStrom" about.

plates    outcome    clinically    evaluation    patient    flowing    signaling    poor    despite    settings    paradigm    immunodeficient    crosstalk    responsiveness    matrix    perception    insights    physio    bridge    constitute    anticancer    prediction    stroma    selectively    consequently    metastatic    mechanical    immune    metastases    capture    models    regression    intervention    generating    discovery    therapies    vivo    patients    containing    plastic    tumors    nowadays    discoveries    polymeric    drug    fundamental    extracellular    experimental    rigid    prevention    tissue    2d    materialize    elicit    rates    preclinical    fronts    antitumor    precision    survival    micrometastases    brain    performed    serum    human    translation    therapeutics    grown    3d    clinical    tumor    colonization    revolutionizing    gap    printed    prevent    cancer    lacking    breakthroughs    cells    molecular    hurdle    translational    followed    cellular    vaccines    therapeutic    functional    compartments    nano    hemodynamics    vessels    drivers    mice    vast    accumulate    treat    pave    nanocarriers    disease    nanomedicines    macrometastatic    libraries    shift   

Project "3DBrainStrom" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙353˙125 €
 EC max contribution 2˙353˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 2˙353˙125.00

Map

 Project objective

Brain metastases represent a major therapeutic challenge. Despite significant breakthroughs in targeted therapies, survival rates of patients with brain metastases remain poor. Nowadays, discovery, development and evaluation of new therapies are performed on human cancer cells grown in 2D on rigid plastic plates followed by in vivo testing in immunodeficient mice. These experimental settings are lacking and constitute a fundamental hurdle for the translation of preclinical discoveries into clinical practice. We propose to establish 3D-printed models of brain metastases (Aim 1), which include brain extracellular matrix, stroma and serum containing immune cells flowing in functional tumor vessels. Our unique models better capture the clinical physio-mechanical tissue properties, signaling pathways, hemodynamics and drug responsiveness. Using our 3D-printed models, we aim to develop two new fronts for identifying novel clinically-relevant molecular drivers (Aim 2) followed by the development of precision nanomedicines (Aim 3). We will exploit our vast experience in anticancer nanomedicines to design three therapeutic approaches that target various cellular compartments involved in brain metastases: 1) Prevention of brain metastatic colonization using targeted nano-vaccines, which elicit antitumor immune response; 2) Intervention of tumor-brain stroma cells crosstalk when brain micrometastases establish; 3) Regression of macrometastatic disease by selectively targeting tumor cells. These approaches will materialize using our libraries of polymeric nanocarriers that selectively accumulate in tumors. This project will result in a paradigm shift by generating new preclinical cancer models that will bridge the translational gap in cancer therapeutics. The insights and tumor-stroma-targeted nanomedicines developed here will pave the way for prediction of patient outcome, revolutionizing our perception of tumor modelling and consequently the way we prevent and treat cancer.

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The information about "3DBRAINSTROM" are provided by the European Opendata Portal: CORDIS opendata.

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