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3DBrainStrom SIGNED

Brain metastases: Deciphering tumor-stroma interactions in three dimensions for the rational design of nanomedicines

Total Cost €

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EC-Contrib. €

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Partnership

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 3DBrainStrom project word cloud

Explore the words cloud of the 3DBrainStrom project. It provides you a very rough idea of what is the project "3DBrainStrom" about.

nanomedicines    tumor    nanocarriers    clinically    prevention    mechanical    regression    discovery    mice    serum    extracellular    disease    intervention    cellular    outcome    settings    3d    crosstalk    therapeutics    lacking    evaluation    materialize    flowing    precision    tissue    compartments    plates    therapeutic    prediction    paradigm    experimental    constitute    drivers    models    hemodynamics    containing    translational    stroma    responsiveness    polymeric    nano    plastic    signaling    functional    perception    followed    treat    breakthroughs    vaccines    generating    bridge    metastases    clinical    antitumor    libraries    matrix    patients    capture    rates    colonization    patient    metastatic    immunodeficient    therapies    survival    revolutionizing    nowadays    tumors    consequently    preclinical    pave    printed    rigid    prevent    accumulate    2d    despite    hurdle    vessels    discoveries    translation    vivo    fundamental    grown    fronts    elicit    micrometastases    poor    human    anticancer    molecular    drug    immune    brain    physio    selectively    vast    performed    gap    shift    insights    macrometastatic    cells    cancer   

Project "3DBrainStrom" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙353˙125 €
 EC max contribution 2˙353˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 2˙353˙125.00

Map

 Project objective

Brain metastases represent a major therapeutic challenge. Despite significant breakthroughs in targeted therapies, survival rates of patients with brain metastases remain poor. Nowadays, discovery, development and evaluation of new therapies are performed on human cancer cells grown in 2D on rigid plastic plates followed by in vivo testing in immunodeficient mice. These experimental settings are lacking and constitute a fundamental hurdle for the translation of preclinical discoveries into clinical practice. We propose to establish 3D-printed models of brain metastases (Aim 1), which include brain extracellular matrix, stroma and serum containing immune cells flowing in functional tumor vessels. Our unique models better capture the clinical physio-mechanical tissue properties, signaling pathways, hemodynamics and drug responsiveness. Using our 3D-printed models, we aim to develop two new fronts for identifying novel clinically-relevant molecular drivers (Aim 2) followed by the development of precision nanomedicines (Aim 3). We will exploit our vast experience in anticancer nanomedicines to design three therapeutic approaches that target various cellular compartments involved in brain metastases: 1) Prevention of brain metastatic colonization using targeted nano-vaccines, which elicit antitumor immune response; 2) Intervention of tumor-brain stroma cells crosstalk when brain micrometastases establish; 3) Regression of macrometastatic disease by selectively targeting tumor cells. These approaches will materialize using our libraries of polymeric nanocarriers that selectively accumulate in tumors. This project will result in a paradigm shift by generating new preclinical cancer models that will bridge the translational gap in cancer therapeutics. The insights and tumor-stroma-targeted nanomedicines developed here will pave the way for prediction of patient outcome, revolutionizing our perception of tumor modelling and consequently the way we prevent and treat cancer.

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The information about "3DBRAINSTROM" are provided by the European Opendata Portal: CORDIS opendata.

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