MagTendon SIGNED
Magnetically Assisted Tissue Engineering Technologies for Tendon Regeneration
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0MagTendon project word cloud
Explore the words cloud of the MagTendon project. It provides you a very rough idea of what is the project "MagTendon" about.
Project "MagTendon" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSIDADE DO MINHO
Organization address contact info |
| Coordinator Country | Portugal [PT] |
| Total cost | 1˙999˙854 € |
| EC max contribution | 1˙999˙854 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-05-01 to 2023-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSIDADE DO MINHO | PT (BRAGA) | coordinator | 1˙999˙854.00 |
Map
Project objective
The poor healing ability of tendons, which play a critical role in the musculoskeletal system, as well as the limitations of currently used therapies have motivated tissue engineering (TE) strategies to develop living tendon substitutes. However, the limited knowledge on tendon development and healing processes has hindered the design of TE procedures that more closely recapitulate tendon morphogenesis. Extending beyond the state-of-the-art, MagTendon will explore conventional and innovative tools such as multimaterial 3 dimensional (3D) bioprinting to design magnetic responsive systems mimicking specific aspects of tendon tissue architecture, composition and biomechanical properties, which, combined with adequate stem cells, will render appropriate behavioural instructions to stimulate the regeneration of tendon tissue. Stem cell bioengineering approaches based on superparamagnetic nanoparticles (SPMNs), namely cell sorting, mechanoreceptors targeting and cell programming, will be used to unveil the cellular signalling pathways that trigger the tenogenic differentiation of the widely and easily obtained human adipose derived stem cells. Simultaneously, the 3D cell-laden magnetic system shall enable sophisticated 3D tissue models to unravel mechanisms behind tendon homeostasis and repair that will support the base knowledge to establish rational design criteria for the biofabrication of living tendon substitutes with the adequate signaling and structural cues to recapitulate tendon tissue developmental patterns. Therefore, the ground-breaking nature of the research proposed relies on the development of disruptive technological concepts for obtaining unique cell-laden 3D magnetically responsive systems that recapitulate key features of the native tissue and that can be further remotely modulated both in vitro and in vivo by the application of external magnetic stimuli, offering the prospect of tendon regeneration as opposed to simple tissue repair.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering published pages: 83-98, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2019.06.003 |
Trends in Biotechnology 38/1 | 2020-01-29 |
| 2019 |
Ana R. Tomás, Ana I. Gonçalves, Elvira Paz, Paulo Freitas, Rui M. A. Domingues, Manuela E. Gomes Magneto-mechanical actuation of magnetic responsive fibrous scaffolds boosts tenogenesis of human adipose stem cells published pages: 18255-18271, ISSN: 2040-3364, DOI: 10.1039/c9nr04355a |
Nanoscale 11/39 | 2020-01-29 |
| 2019 |
Raquel Costa-Almeida, Isabel Calejo, Roberta Altieri, Rui M A Domingues, Emanuele Giordano, Rui L Reis, Manuela E Gomes Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair published pages: 34104, ISSN: 1748-605X, DOI: 10.1088/1748-605x/ab0de6 |
Biomedical Materials 14/3 | 2020-01-29 |
| 2019 |
Isabel Calejo, Raquel Costaâ€Almeida, Rui L. Reis, Manuela E. Gomes A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendonâ€toâ€Bone Interface Gradient Scaffolds published pages: 1900200, ISSN: 2192-2640, DOI: 10.1002/adhm.201900200 |
Advanced Healthcare Materials 8/15 | 2020-01-29 |
| 2019 |
Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies published pages: 3002, ISSN: 1422-0067, DOI: 10.3390/ijms20123002 |
International Journal of Molecular Sciences 20/12 | 2020-01-29 |
| 2019 |
Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes Enthesis Tissue Engineering: Biological Requirements Meet at the Interface published pages: 330-356, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0383 |
Tissue Engineering Part B: Reviews 25/4 | 2020-01-29 |
| 2019 |
Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes Evaluation of tenogenic differentiation potential of selected subpopulations of human adiposeâ€derived stem cells published pages: 2204-2217, ISSN: 1932-6254, DOI: 10.1002/term.2967 |
Journal of Tissue Engineering and Regenerative Medicine 13/12 | 2020-01-29 |
| 2020 |
Bárbara B Mendes, Manuel Gómez-Florit, Alex G Hamilton, Michael S Detamore, Rui M A Domingues, Rui L Reis, Manuela E Gomes Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structures published pages: 15012, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab33e8 |
Biofabrication 12/1 | 2020-01-29 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MAGTENDON" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MAGTENDON" are provided by the European Opendata Portal: CORDIS opendata.