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MagTendon SIGNED

Magnetically Assisted Tissue Engineering Technologies for Tendon Regeneration

Total Cost €

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EC-Contrib. €

0

Partnership

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 MagTendon project word cloud

Explore the words cloud of the MagTendon project. It provides you a very rough idea of what is the project "MagTendon" about.

unravel    mechanisms    programming    patterns    architecture    nature    technological    developmental    easily    signalling    strategies    cell    repair    play    trigger    living    engineering    hindered    adipose    relies    external    responsive    opposed    modulated    criteria    motivated    recapitulate    breaking    vivo    unveil    dimensional    vitro    poor    magnetic    base    closely    laden    superparamagnetic    nanoparticles    multimaterial    tissue    prospect    obtaining    cellular    magnetically    explore    rational    cells    te    stimulate    3d    innovative    therapies    appropriate    sorting    tools    sophisticated    models    morphogenesis    render    biofabrication    composition    instructions    structural    behavioural    bioengineering    tendons    magtendon    regeneration    human    signaling    spmns    mechanoreceptors    bioprinting    stem    mimicking    native    limited    disruptive    healing    tenogenic    tendon    ground    cues    substitutes    homeostasis    biomechanical    differentiation    musculoskeletal    remotely    critical    stimuli    limitations    simultaneously    combined    conventional   

Project "MagTendon" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DO MINHO 

Organization address
address: LARGO DO PACO
city: BRAGA
postcode: 4704 553
website: www.uminho.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙999˙854 €
 EC max contribution 1˙999˙854 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO MINHO PT (BRAGA) coordinator 1˙999˙854.00

Map

 Project objective

The poor healing ability of tendons, which play a critical role in the musculoskeletal system, as well as the limitations of currently used therapies have motivated tissue engineering (TE) strategies to develop living tendon substitutes. However, the limited knowledge on tendon development and healing processes has hindered the design of TE procedures that more closely recapitulate tendon morphogenesis. Extending beyond the state-of-the-art, MagTendon will explore conventional and innovative tools such as multimaterial 3 dimensional (3D) bioprinting to design magnetic responsive systems mimicking specific aspects of tendon tissue architecture, composition and biomechanical properties, which, combined with adequate stem cells, will render appropriate behavioural instructions to stimulate the regeneration of tendon tissue. Stem cell bioengineering approaches based on superparamagnetic nanoparticles (SPMNs), namely cell sorting, mechanoreceptors targeting and cell programming, will be used to unveil the cellular signalling pathways that trigger the tenogenic differentiation of the widely and easily obtained human adipose derived stem cells. Simultaneously, the 3D cell-laden magnetic system shall enable sophisticated 3D tissue models to unravel mechanisms behind tendon homeostasis and repair that will support the base knowledge to establish rational design criteria for the biofabrication of living tendon substitutes with the adequate signaling and structural cues to recapitulate tendon tissue developmental patterns. Therefore, the ground-breaking nature of the research proposed relies on the development of disruptive technological concepts for obtaining unique cell-laden 3D magnetically responsive systems that recapitulate key features of the native tissue and that can be further remotely modulated both in vitro and in vivo by the application of external magnetic stimuli, offering the prospect of tendon regeneration as opposed to simple tissue repair.

 Publications

year authors and title journal last update
List of publications.
2020 Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering
published pages: 83-98, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2019.06.003
Trends in Biotechnology 38/1 2020-01-29
2019 Ana R. Tomás, Ana I. Gonçalves, Elvira Paz, Paulo Freitas, Rui M. A. Domingues, Manuela E. Gomes
Magneto-mechanical actuation of magnetic responsive fibrous scaffolds boosts tenogenesis of human adipose stem cells
published pages: 18255-18271, ISSN: 2040-3364, DOI: 10.1039/c9nr04355a
Nanoscale 11/39 2020-01-29
2019 Raquel Costa-Almeida, Isabel Calejo, Roberta Altieri, Rui M A Domingues, Emanuele Giordano, Rui L Reis, Manuela E Gomes
Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair
published pages: 34104, ISSN: 1748-605X, DOI: 10.1088/1748-605x/ab0de6
Biomedical Materials 14/3 2020-01-29
2019 Isabel Calejo, Raquel Costa‐Almeida, Rui L. Reis, Manuela E. Gomes
A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds
published pages: 1900200, ISSN: 2192-2640, DOI: 10.1002/adhm.201900200
Advanced Healthcare Materials 8/15 2020-01-29
2019 Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes
Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies
published pages: 3002, ISSN: 1422-0067, DOI: 10.3390/ijms20123002
International Journal of Molecular Sciences 20/12 2020-01-29
2019 Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
Enthesis Tissue Engineering: Biological Requirements Meet at the Interface
published pages: 330-356, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0383
Tissue Engineering Part B: Reviews 25/4 2020-01-29
2019 Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells
published pages: 2204-2217, ISSN: 1932-6254, DOI: 10.1002/term.2967
Journal of Tissue Engineering and Regenerative Medicine 13/12 2020-01-29
2020 Bárbara B Mendes, Manuel Gómez-Florit, Alex G Hamilton, Michael S Detamore, Rui M A Domingues, Rui L Reis, Manuela E Gomes
Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structures
published pages: 15012, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab33e8
Biofabrication 12/1 2020-01-29

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The information about "MAGTENDON" are provided by the European Opendata Portal: CORDIS opendata.

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