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MagTendon SIGNED

Magnetically Assisted Tissue Engineering Technologies for Tendon Regeneration

Total Cost €

0

EC-Contrib. €

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Partnership

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 MagTendon project word cloud

Explore the words cloud of the MagTendon project. It provides you a very rough idea of what is the project "MagTendon" about.

morphogenesis    tenogenic    cells    ground    te    unravel    living    tendons    musculoskeletal    easily    closely    mimicking    programming    developmental    differentiation    play    spmns    composition    biofabrication    adipose    repair    disruptive    stimuli    mechanoreceptors    sorting    strategies    behavioural    breaking    remotely    stem    signalling    base    engineering    models    mechanisms    responsive    magnetic    conventional    opposed    tendon    vivo    simultaneously    criteria    obtaining    relies    biomechanical    magnetically    vitro    3d    homeostasis    explore    stimulate    cues    dimensional    multimaterial    limitations    instructions    structural    prospect    external    modulated    critical    nature    superparamagnetic    regeneration    cellular    tools    bioprinting    trigger    signaling    substitutes    technological    therapies    innovative    hindered    appropriate    native    tissue    unveil    combined    poor    cell    sophisticated    recapitulate    render    motivated    magtendon    limited    nanoparticles    patterns    healing    rational    laden    bioengineering    human    architecture   

Project "MagTendon" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSIDADE DO MINHO 

Organization address
address: LARGO DO PACO
city: BRAGA
postcode: 4704 553
website: www.uminho.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Portugal [PT]
 Total cost 1˙999˙854 €
 EC max contribution 1˙999˙854 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO MINHO PT (BRAGA) coordinator 1˙999˙854.00

Map

 Project objective

The poor healing ability of tendons, which play a critical role in the musculoskeletal system, as well as the limitations of currently used therapies have motivated tissue engineering (TE) strategies to develop living tendon substitutes. However, the limited knowledge on tendon development and healing processes has hindered the design of TE procedures that more closely recapitulate tendon morphogenesis. Extending beyond the state-of-the-art, MagTendon will explore conventional and innovative tools such as multimaterial 3 dimensional (3D) bioprinting to design magnetic responsive systems mimicking specific aspects of tendon tissue architecture, composition and biomechanical properties, which, combined with adequate stem cells, will render appropriate behavioural instructions to stimulate the regeneration of tendon tissue. Stem cell bioengineering approaches based on superparamagnetic nanoparticles (SPMNs), namely cell sorting, mechanoreceptors targeting and cell programming, will be used to unveil the cellular signalling pathways that trigger the tenogenic differentiation of the widely and easily obtained human adipose derived stem cells. Simultaneously, the 3D cell-laden magnetic system shall enable sophisticated 3D tissue models to unravel mechanisms behind tendon homeostasis and repair that will support the base knowledge to establish rational design criteria for the biofabrication of living tendon substitutes with the adequate signaling and structural cues to recapitulate tendon tissue developmental patterns. Therefore, the ground-breaking nature of the research proposed relies on the development of disruptive technological concepts for obtaining unique cell-laden 3D magnetically responsive systems that recapitulate key features of the native tissue and that can be further remotely modulated both in vitro and in vivo by the application of external magnetic stimuli, offering the prospect of tendon regeneration as opposed to simple tissue repair.

 Publications

year authors and title journal last update
List of publications.
2020 Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering
published pages: 83-98, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2019.06.003 		Trends in Biotechnology 38/1 2020-01-29
2019 Ana R. Tomás, Ana I. Gonçalves, Elvira Paz, Paulo Freitas, Rui M. A. Domingues, Manuela E. Gomes
Magneto-mechanical actuation of magnetic responsive fibrous scaffolds boosts tenogenesis of human adipose stem cells
published pages: 18255-18271, ISSN: 2040-3364, DOI: 10.1039/c9nr04355a 		Nanoscale 11/39 2020-01-29
2019 Raquel Costa-Almeida, Isabel Calejo, Roberta Altieri, Rui M A Domingues, Emanuele Giordano, Rui L Reis, Manuela E Gomes
Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair
published pages: 34104, ISSN: 1748-605X, DOI: 10.1088/1748-605x/ab0de6 		Biomedical Materials 14/3 2020-01-29
2019 Isabel Calejo, Raquel Costa‐Almeida, Rui L. Reis, Manuela E. Gomes
A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds
published pages: 1900200, ISSN: 2192-2640, DOI: 10.1002/adhm.201900200 		Advanced Healthcare Materials 8/15 2020-01-29
2019 Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes
Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies
published pages: 3002, ISSN: 1422-0067, DOI: 10.3390/ijms20123002 		International Journal of Molecular Sciences 20/12 2020-01-29
2019 Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
Enthesis Tissue Engineering: Biological Requirements Meet at the Interface
published pages: 330-356, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0383 		Tissue Engineering Part B: Reviews 25/4 2020-01-29
2019 Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells
published pages: 2204-2217, ISSN: 1932-6254, DOI: 10.1002/term.2967 		Journal of Tissue Engineering and Regenerative Medicine 13/12 2020-01-29
2020 Bárbara B Mendes, Manuel Gómez-Florit, Alex G Hamilton, Michael S Detamore, Rui M A Domingues, Rui L Reis, Manuela E Gomes
Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structures
published pages: 15012, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab33e8 		Biofabrication 12/1 2020-01-29

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The information about "MAGTENDON" are provided by the European Opendata Portal: CORDIS opendata.

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