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MagTendon SIGNED

Magnetically Assisted Tissue Engineering Technologies for Tendon Regeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MagTendon project word cloud

Explore the words cloud of the MagTendon project. It provides you a very rough idea of what is the project "MagTendon" about.

biofabrication    therapies    breaking    mechanisms    magnetically    easily    play    disruptive    stimuli    3d    repair    explore    external    strategies    trigger    ground    spmns    rational    limited    tendons    responsive    poor    opposed    remotely    critical    nature    base    substitutes    native    homeostasis    motivated    recapitulate    sophisticated    programming    simultaneously    adipose    cues    appropriate    magtendon    regeneration    differentiation    hindered    models    tenogenic    nanoparticles    prospect    vivo    cells    laden    relies    patterns    human    te    unravel    magnetic    bioengineering    cell    architecture    dimensional    innovative    sorting    bioprinting    obtaining    tools    multimaterial    stem    behavioural    instructions    tissue    living    structural    mimicking    conventional    vitro    stimulate    musculoskeletal    unveil    render    signalling    superparamagnetic    developmental    biomechanical    tendon    limitations    criteria    combined    morphogenesis    healing    signaling    mechanoreceptors    composition    closely    engineering    cellular    modulated    technological   

Project "MagTendon" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSIDADE DO MINHO 

Organization address
address: LARGO DO PACO
city: BRAGA
postcode: 4704 553
website: www.uminho.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Portugal [PT]
 Total cost 1˙999˙854 €
 EC max contribution 1˙999˙854 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO MINHO PT (BRAGA) coordinator 1˙999˙854.00

Map

 Project objective

The poor healing ability of tendons, which play a critical role in the musculoskeletal system, as well as the limitations of currently used therapies have motivated tissue engineering (TE) strategies to develop living tendon substitutes. However, the limited knowledge on tendon development and healing processes has hindered the design of TE procedures that more closely recapitulate tendon morphogenesis. Extending beyond the state-of-the-art, MagTendon will explore conventional and innovative tools such as multimaterial 3 dimensional (3D) bioprinting to design magnetic responsive systems mimicking specific aspects of tendon tissue architecture, composition and biomechanical properties, which, combined with adequate stem cells, will render appropriate behavioural instructions to stimulate the regeneration of tendon tissue. Stem cell bioengineering approaches based on superparamagnetic nanoparticles (SPMNs), namely cell sorting, mechanoreceptors targeting and cell programming, will be used to unveil the cellular signalling pathways that trigger the tenogenic differentiation of the widely and easily obtained human adipose derived stem cells. Simultaneously, the 3D cell-laden magnetic system shall enable sophisticated 3D tissue models to unravel mechanisms behind tendon homeostasis and repair that will support the base knowledge to establish rational design criteria for the biofabrication of living tendon substitutes with the adequate signaling and structural cues to recapitulate tendon tissue developmental patterns. Therefore, the ground-breaking nature of the research proposed relies on the development of disruptive technological concepts for obtaining unique cell-laden 3D magnetically responsive systems that recapitulate key features of the native tissue and that can be further remotely modulated both in vitro and in vivo by the application of external magnetic stimuli, offering the prospect of tendon regeneration as opposed to simple tissue repair.

 Publications

year authors and title journal last update
List of publications.
2020 Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering
published pages: 83-98, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2019.06.003 		Trends in Biotechnology 38/1 2020-01-29
2019 Ana R. Tomás, Ana I. Gonçalves, Elvira Paz, Paulo Freitas, Rui M. A. Domingues, Manuela E. Gomes
Magneto-mechanical actuation of magnetic responsive fibrous scaffolds boosts tenogenesis of human adipose stem cells
published pages: 18255-18271, ISSN: 2040-3364, DOI: 10.1039/c9nr04355a 		Nanoscale 11/39 2020-01-29
2019 Raquel Costa-Almeida, Isabel Calejo, Roberta Altieri, Rui M A Domingues, Emanuele Giordano, Rui L Reis, Manuela E Gomes
Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair
published pages: 34104, ISSN: 1748-605X, DOI: 10.1088/1748-605x/ab0de6 		Biomedical Materials 14/3 2020-01-29
2019 Isabel Calejo, Raquel Costa‐Almeida, Rui L. Reis, Manuela E. Gomes
A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds
published pages: 1900200, ISSN: 2192-2640, DOI: 10.1002/adhm.201900200 		Advanced Healthcare Materials 8/15 2020-01-29
2019 Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes
Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies
published pages: 3002, ISSN: 1422-0067, DOI: 10.3390/ijms20123002 		International Journal of Molecular Sciences 20/12 2020-01-29
2019 Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
Enthesis Tissue Engineering: Biological Requirements Meet at the Interface
published pages: 330-356, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0383 		Tissue Engineering Part B: Reviews 25/4 2020-01-29
2019 Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells
published pages: 2204-2217, ISSN: 1932-6254, DOI: 10.1002/term.2967 		Journal of Tissue Engineering and Regenerative Medicine 13/12 2020-01-29
2020 Bárbara B Mendes, Manuel Gómez-Florit, Alex G Hamilton, Michael S Detamore, Rui M A Domingues, Rui L Reis, Manuela E Gomes
Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structures
published pages: 15012, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab33e8 		Biofabrication 12/1 2020-01-29

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The information about "MAGTENDON" are provided by the European Opendata Portal: CORDIS opendata.

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