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Novel insights into the sensing of salt stress in plants: understanding the relationship between salt stress response and cytosolic pH changes.

Total Cost €


EC-Contrib. €






 sigNal project word cloud

Explore the words cloud of the sigNal project. It provides you a very rough idea of what is the project "sigNal" about.

shoots    hypothesis    signal    thr    ph    sos3    meet    shift    provokes    relaying    plant    group    initiate    determinants    dependent    accumulation    activates    antiporter    sos2    integrate    stage    na    perceives    sensed    variety    signature    ca    regulates    overly    roots    components    sos1    experiments    posit    criteria    cytosolic    intracellular    learned    ratio    triggered    salt    localized    messenger    recruits    concentration    stresses    cells    core    prof    induce    signals    interactions    alkalinisation    plants    signalling    imaging    kinase    partition    subcellular    sensitive    sos    experimental    stress    ser    visualisation    homeostasis    additional    abiotic    phosphorylation    calcium    demonstrated    toxic    schumacher    technics    salinity    mechanisms    protein    existence    structural    fluorescence    regulatory    sodicity    levels    pm    activate    responsible    free    postdoct    sensor    input    activated    prevents    duiring    localisations    paradigm    sensing    alkaline   

Project "sigNal" data sheet

The following table provides information about the project.


Organization address
postcode: 69117

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The Salt Overly Sensitive (SOS) pathway is one of the main regulatory systems responsible for Na homeostasis in plants. The SOS pathway is activated by salt stress and comprises three core components: SOS1, SOS2 and SOS3. SOS3 is a calcium (Ca) sensor that perceives the increase of intracellular Ca triggered by salt stress and recruits SOS2, a Ser/Thr protein kinase, to the PM. The complex activates protein SOS1 by phosphorylation, a PM-localized Na/H antiporter that prevents the accumulation of Na to toxic levels and regulates Na partition between roots and shoots. Cytosolic free Ca is a common second messenger in the signalling of a variety of abiotic stresses. The wide range of Ca-activated responses lead us to posit the existence of additional mechanisms relaying input signals that, together with this Ca signature, would initiate the specific response for a particular stress. The hypothesis of my proposal is that the increase in intracellular Na concentration provokes the alkalinisation of the intracellular pH, what would be sensed by SOS3. SOS3 would work as pH and Ca sensor, which would integrate this pH shift and the Ca signature to activate SOS pathway.

To support the hypothesis of cytosolic alkalinisation as a salt stress signal and SOS3 as a Ca and pH sensor, two experimental criteria must be meet: (1) salinity should induce an alkaline pH shift in plant cells, and (2) structural determinants of pH-sensing should be demonstrated in SOS3. To achieve my goal: (1) I will use a system, improved by Prof. Schumacher’s group, which allows the visualisation of pH changes in selected subcellular localisations through fluorescence ratio imaging experiments; and (2) I will use the technics learned and used duiring my postdoct stage to study whether SOS3 interactions and/or activity are pH dependent.

This research will provide a new paradigm of how sodicity is sensed by plant cells.

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The information about "SIGNAL" are provided by the European Opendata Portal: CORDIS opendata.

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