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sigNal SIGNED

Novel insights into the sensing of salt stress in plants: understanding the relationship between salt stress response and cytosolic pH changes.

Total Cost €

EC-Contrib. €

Partnership

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sigNal project word cloud

Explore the words cloud of the sigNal project. It provides you a very rough idea of what is the project "sigNal" about.

shoots hypothesis signal thr ph sos3 meet shift provokes relaying plant group initiate determinants dependent accumulation activates antiporter sos2 integrate stage na perceives sensed variety signature ca regulates overly roots components sos1 experiments posit criteria cytosolic intracellular learned ratio triggered salt localized messenger recruits concentration stresses cells core prof induce signals interactions alkalinisation plants signalling imaging kinase partition subcellular sensitive sos experimental stress ser visualisation homeostasis additional abiotic phosphorylation calcium demonstrated toxic schumacher technics salinity mechanisms protein existence structural fluorescence regulatory sodicity levels pm activate responsible free postdoct sensor input activated prevents duiring localisations paradigm sensing alkaline

Project "sigNal" data sheet

The following table provides information about the project.

Coordinator	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	171˙460 €
EC max contribution	171˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	coordinator	171˙460.00

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Project objective

The Salt Overly Sensitive (SOS) pathway is one of the main regulatory systems responsible for Na homeostasis in plants. The SOS pathway is activated by salt stress and comprises three core components: SOS1, SOS2 and SOS3. SOS3 is a calcium (Ca) sensor that perceives the increase of intracellular Ca triggered by salt stress and recruits SOS2, a Ser/Thr protein kinase, to the PM. The complex activates protein SOS1 by phosphorylation, a PM-localized Na/H antiporter that prevents the accumulation of Na to toxic levels and regulates Na partition between roots and shoots. Cytosolic free Ca is a common second messenger in the signalling of a variety of abiotic stresses. The wide range of Ca-activated responses lead us to posit the existence of additional mechanisms relaying input signals that, together with this Ca signature, would initiate the specific response for a particular stress. The hypothesis of my proposal is that the increase in intracellular Na concentration provokes the alkalinisation of the intracellular pH, what would be sensed by SOS3. SOS3 would work as pH and Ca sensor, which would integrate this pH shift and the Ca signature to activate SOS pathway.

To support the hypothesis of cytosolic alkalinisation as a salt stress signal and SOS3 as a Ca and pH sensor, two experimental criteria must be meet: (1) salinity should induce an alkaline pH shift in plant cells, and (2) structural determinants of pH-sensing should be demonstrated in SOS3. To achieve my goal: (1) I will use a system, improved by Prof. Schumacher’s group, which allows the visualisation of pH changes in selected subcellular localisations through fluorescence ratio imaging experiments; and (2) I will use the technics learned and used duiring my postdoct stage to study whether SOS3 interactions and/or activity are pH dependent.

This research will provide a new paradigm of how sodicity is sensed by plant cells.

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The information about "SIGNAL" are provided by the European Opendata Portal: CORDIS opendata.