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Novel insights into the sensing of salt stress in plants: understanding the relationship between salt stress response and cytosolic pH changes.

Total Cost €


EC-Contrib. €






 sigNal project word cloud

Explore the words cloud of the sigNal project. It provides you a very rough idea of what is the project "sigNal" about.

experiments    cells    sos    induce    integrate    localisations    responsible    thr    visualisation    determinants    sos2    ser    triggered    shift    salt    additional    group    roots    protein    hypothesis    signals    imaging    core    structural    signalling    duiring    salinity    intracellular    activated    mechanisms    subcellular    kinase    sensing    accumulation    interactions    criteria    phosphorylation    shoots    overly    localized    sensitive    provokes    experimental    fluorescence    alkalinisation    partition    prevents    signature    prof    sensed    recruits    stress    perceives    concentration    postdoct    stresses    sos3    na    plant    ca    posit    pm    learned    ratio    signal    demonstrated    stage    activate    messenger    activates    sensor    initiate    plants    homeostasis    variety    regulates    meet    free    existence    components    sos1    calcium    regulatory    alkaline    schumacher    cytosolic    dependent    sodicity    levels    relaying    antiporter    toxic    paradigm    input    technics    abiotic    ph   

Project "sigNal" data sheet

The following table provides information about the project.


Organization address
postcode: 69117

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The Salt Overly Sensitive (SOS) pathway is one of the main regulatory systems responsible for Na homeostasis in plants. The SOS pathway is activated by salt stress and comprises three core components: SOS1, SOS2 and SOS3. SOS3 is a calcium (Ca) sensor that perceives the increase of intracellular Ca triggered by salt stress and recruits SOS2, a Ser/Thr protein kinase, to the PM. The complex activates protein SOS1 by phosphorylation, a PM-localized Na/H antiporter that prevents the accumulation of Na to toxic levels and regulates Na partition between roots and shoots. Cytosolic free Ca is a common second messenger in the signalling of a variety of abiotic stresses. The wide range of Ca-activated responses lead us to posit the existence of additional mechanisms relaying input signals that, together with this Ca signature, would initiate the specific response for a particular stress. The hypothesis of my proposal is that the increase in intracellular Na concentration provokes the alkalinisation of the intracellular pH, what would be sensed by SOS3. SOS3 would work as pH and Ca sensor, which would integrate this pH shift and the Ca signature to activate SOS pathway.

To support the hypothesis of cytosolic alkalinisation as a salt stress signal and SOS3 as a Ca and pH sensor, two experimental criteria must be meet: (1) salinity should induce an alkaline pH shift in plant cells, and (2) structural determinants of pH-sensing should be demonstrated in SOS3. To achieve my goal: (1) I will use a system, improved by Prof. Schumacher’s group, which allows the visualisation of pH changes in selected subcellular localisations through fluorescence ratio imaging experiments; and (2) I will use the technics learned and used duiring my postdoct stage to study whether SOS3 interactions and/or activity are pH dependent.

This research will provide a new paradigm of how sodicity is sensed by plant cells.

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The information about "SIGNAL" are provided by the European Opendata Portal: CORDIS opendata.

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