Opendata, web and dolomites

MINIRES

A Minimalist Peptide Elastomer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MINIRES project word cloud

Explore the words cloud of the MINIRES project. It provides you a very rough idea of what is the project "MINIRES" about.

foldhalo    deposited    peptide    structural    res    small    induces    length    outcomes    lab    huge    possibility    accelerate    course    trivial    simplicity    found    perform    opening    full    lies    move    elasticity    formulations    rubber    critical    foreseeing    sequence    307108    jumping    intend    licensing    fact    cross    advantage    start    chemical    setting    erc    supramolecular    linking    determines    emergence    resilin    family    pure    scouting    vs    either    elastomeric    industrial    insects    modifications    grant    compound    modification    technically    320    scalability    protein    chains    acids    creation    validating    material    bioelastomer    flight    outstanding    natural    unmodified    biomimetic    starting    maturity    minires    minimalist    peptides    amino    exon    repeat    suitable    polymeric    surprising    halogenation    valorizing    physical    market    feasibility    commercial    strategy    resembling    patent    revolutionary   

Project "MINIRES" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI MILANO 

Organization address
address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133
website: www.polimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 150˙000.00

Map

 Project objective

The MINIRES project aims at developing and bringing to the market a revolutionary bioelastomer material based on a novel strategy of structural modification of a “minimalist” peptide sequence derived from Resilin (Res), i.e., a polymeric rubber-like natural protein with outstanding elasticity, critical in the flight and jumping systems of insects. In the course of the ERC funded Starting Grant FOLDHALO (grant agreement no. 307108), I focused on the modification of a repeat sequence of the Exon-1 (~320 amino acids) of Res. We found that a biomimetic chemical modification of this sequence (i.e., halogenation) induces the emergence of elastomeric properties resembling those of the full-length Res protein. This is surprising for such a short peptide, and the unmodified peptide, in fact, does not show such properties. Halogenation determines a huge change in the material properties due to the induced physical (supramolecular) cross-linking of the peptide chains. The main advantage of the novel “minimalist” bioelastomer that we developed lies in its chemical and structural simplicity. This simplicity allows foreseeing easy industrial scalability at low costs, trivial processing, either as pure compound or component of elastomeric formulations, as well as possibility of further chemical and structural modifications (opening up a family of small elastomeric peptides). Expected outcomes of the MINIRES project are to perform a technical and commercial feasibility study to move the developed “minimalist” bioelastomer from the lab to the market. In particular, within the MINIRES project, we intend to accelerate the maturity level of this technology, by technically validating it, as well as scouting market opportunities and setting up a suitable exploitation strategy (licensing vs. start-up creation) for valorizing the patent that has being deposited.

 Publications

year authors and title journal last update
List of publications.
2019 Kavitha Buntara Sanjeeva, Claudia Pigliacelli, Lara Gazzera, Valentina Dichiarante, Francesca Baldelli Bombelli, Pierangelo Metrangolo
Halogen bond-assisted self-assembly of gold nanoparticles in solution and on a planar surface
published pages: 18407-18415, ISSN: 2040-3364, DOI: 10.1039/c9nr07054k
Nanoscale 11/39 2020-02-18
2019 Claudia Pigliacelli, Kavitha Buntara Sanjeeva, Nonappa, Andrea Pizzi, Alessandro Gori, Francesca Baldelli Bombelli, Pierangelo Metrangolo
In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination
published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.8b08805
ACS Nano 2020-02-18
2019 Alfonso Gautieri, Alberto Milani, Andrea Pizzi, Federica Rigoldi, Alberto Redaelli, Pierangelo Metrangolo
Molecular dynamics investigation of halogenated amyloidogenic peptides
published pages: , ISSN: 1610-2940, DOI: 10.1007/s00894-019-4012-9
Journal of Molecular Modeling 25/5 2020-02-18
2019 Andrea Pizzi, Haxel Lionel Ozores, Martín Calvelo, Rebeca García-Fandiño, Manuel Amorín, Nicola Demitri, Giancarlo Terraneo, Silvia Bracco, Angiolina Comotti, Piero Sozzani, Charl X. Bezuidenhout, Pierangelo Metrangolo, Juan R. Granja
Tight Xenon Confinement in a Crystalline Sandwich-like Hydrogen-Bonded Dimeric Capsule of a Cyclic Peptide
published pages: 14472-14476, ISSN: 1433-7851, DOI: 10.1002/anie.201906599
Angewandte Chemie International Edition 58/41 2020-02-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MINIRES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MINIRES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

FunDiT (2019)

Functional Diversity of T cells

Read More