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MINIRES

A Minimalist Peptide Elastomer

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MINIRES project word cloud

Explore the words cloud of the MINIRES project. It provides you a very rough idea of what is the project "MINIRES" about.

320    advantage    pure    huge    intend    setting    supramolecular    perform    induces    deposited    minires    determines    foldhalo    patent    polymeric    critical    scouting    accelerate    peptides    commercial    maturity    modifications    feasibility    simplicity    move    starting    fact    elastomeric    acids    physical    length    trivial    outstanding    technically    modification    exon    start    formulations    amino    suitable    rubber    cross    surprising    creation    strategy    scalability    small    307108    repeat    chemical    emergence    revolutionary    lies    jumping    material    biomimetic    peptide    possibility    industrial    structural    sequence    full    unmodified    protein    lab    insects    minimalist    erc    market    opening    vs    found    natural    licensing    valorizing    bioelastomer    either    halogenation    elasticity    course    validating    foreseeing    outcomes    grant    compound    resilin    linking    flight    family    resembling    res    chains   

Project "MINIRES" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI MILANO 

Organization address
address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133
website: www.polimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 150˙000.00

Map

 Project objective

The MINIRES project aims at developing and bringing to the market a revolutionary bioelastomer material based on a novel strategy of structural modification of a “minimalist” peptide sequence derived from Resilin (Res), i.e., a polymeric rubber-like natural protein with outstanding elasticity, critical in the flight and jumping systems of insects. In the course of the ERC funded Starting Grant FOLDHALO (grant agreement no. 307108), I focused on the modification of a repeat sequence of the Exon-1 (~320 amino acids) of Res. We found that a biomimetic chemical modification of this sequence (i.e., halogenation) induces the emergence of elastomeric properties resembling those of the full-length Res protein. This is surprising for such a short peptide, and the unmodified peptide, in fact, does not show such properties. Halogenation determines a huge change in the material properties due to the induced physical (supramolecular) cross-linking of the peptide chains. The main advantage of the novel “minimalist” bioelastomer that we developed lies in its chemical and structural simplicity. This simplicity allows foreseeing easy industrial scalability at low costs, trivial processing, either as pure compound or component of elastomeric formulations, as well as possibility of further chemical and structural modifications (opening up a family of small elastomeric peptides). Expected outcomes of the MINIRES project are to perform a technical and commercial feasibility study to move the developed “minimalist” bioelastomer from the lab to the market. In particular, within the MINIRES project, we intend to accelerate the maturity level of this technology, by technically validating it, as well as scouting market opportunities and setting up a suitable exploitation strategy (licensing vs. start-up creation) for valorizing the patent that has being deposited.

 Publications

year authors and title journal last update
List of publications.
2019 Kavitha Buntara Sanjeeva, Claudia Pigliacelli, Lara Gazzera, Valentina Dichiarante, Francesca Baldelli Bombelli, Pierangelo Metrangolo
Halogen bond-assisted self-assembly of gold nanoparticles in solution and on a planar surface
published pages: 18407-18415, ISSN: 2040-3364, DOI: 10.1039/c9nr07054k
Nanoscale 11/39 2020-02-18
2019 Claudia Pigliacelli, Kavitha Buntara Sanjeeva, Nonappa, Andrea Pizzi, Alessandro Gori, Francesca Baldelli Bombelli, Pierangelo Metrangolo
In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination
published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.8b08805
ACS Nano 2020-02-18
2019 Alfonso Gautieri, Alberto Milani, Andrea Pizzi, Federica Rigoldi, Alberto Redaelli, Pierangelo Metrangolo
Molecular dynamics investigation of halogenated amyloidogenic peptides
published pages: , ISSN: 1610-2940, DOI: 10.1007/s00894-019-4012-9
Journal of Molecular Modeling 25/5 2020-02-18
2019 Andrea Pizzi, Haxel Lionel Ozores, Martín Calvelo, Rebeca García-Fandiño, Manuel Amorín, Nicola Demitri, Giancarlo Terraneo, Silvia Bracco, Angiolina Comotti, Piero Sozzani, Charl X. Bezuidenhout, Pierangelo Metrangolo, Juan R. Granja
Tight Xenon Confinement in a Crystalline Sandwich-like Hydrogen-Bonded Dimeric Capsule of a Cyclic Peptide
published pages: 14472-14476, ISSN: 1433-7851, DOI: 10.1002/anie.201906599
Angewandte Chemie International Edition 58/41 2020-02-18

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