MINIRES
A Minimalist Peptide Elastomer
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0MINIRES project word cloud
Explore the words cloud of the MINIRES project. It provides you a very rough idea of what is the project "MINIRES" about.
Project "MINIRES" data sheet
The following table provides information about the project.
| Coordinator |
POLITECNICO DI MILANO
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Total cost | 150˙000 € |
| EC max contribution | 150˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-04-01 to 2019-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | POLITECNICO DI MILANO | IT (MILANO) | coordinator | 150˙000.00 |
Map
Project objective
The MINIRES project aims at developing and bringing to the market a revolutionary bioelastomer material based on a novel strategy of structural modification of a “minimalist” peptide sequence derived from Resilin (Res), i.e., a polymeric rubber-like natural protein with outstanding elasticity, critical in the flight and jumping systems of insects. In the course of the ERC funded Starting Grant FOLDHALO (grant agreement no. 307108), I focused on the modification of a repeat sequence of the Exon-1 (~320 amino acids) of Res. We found that a biomimetic chemical modification of this sequence (i.e., halogenation) induces the emergence of elastomeric properties resembling those of the full-length Res protein. This is surprising for such a short peptide, and the unmodified peptide, in fact, does not show such properties. Halogenation determines a huge change in the material properties due to the induced physical (supramolecular) cross-linking of the peptide chains. The main advantage of the novel “minimalist” bioelastomer that we developed lies in its chemical and structural simplicity. This simplicity allows foreseeing easy industrial scalability at low costs, trivial processing, either as pure compound or component of elastomeric formulations, as well as possibility of further chemical and structural modifications (opening up a family of small elastomeric peptides). Expected outcomes of the MINIRES project are to perform a technical and commercial feasibility study to move the developed “minimalist” bioelastomer from the lab to the market. In particular, within the MINIRES project, we intend to accelerate the maturity level of this technology, by technically validating it, as well as scouting market opportunities and setting up a suitable exploitation strategy (licensing vs. start-up creation) for valorizing the patent that has being deposited.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Kavitha Buntara Sanjeeva, Claudia Pigliacelli, Lara Gazzera, Valentina Dichiarante, Francesca Baldelli Bombelli, Pierangelo Metrangolo Halogen bond-assisted self-assembly of gold nanoparticles in solution and on a planar surface published pages: 18407-18415, ISSN: 2040-3364, DOI: 10.1039/c9nr07054k |
Nanoscale 11/39 | 2020-02-18 |
| 2019 |
Claudia Pigliacelli, Kavitha Buntara Sanjeeva, Nonappa, Andrea Pizzi, Alessandro Gori, Francesca Baldelli Bombelli, Pierangelo Metrangolo In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.8b08805 |
ACS Nano | 2020-02-18 |
| 2019 |
Alfonso Gautieri, Alberto Milani, Andrea Pizzi, Federica Rigoldi, Alberto Redaelli, Pierangelo Metrangolo Molecular dynamics investigation of halogenated amyloidogenic peptides published pages: , ISSN: 1610-2940, DOI: 10.1007/s00894-019-4012-9 |
Journal of Molecular Modeling 25/5 | 2020-02-18 |
| 2019 |
Andrea Pizzi, Haxel Lionel Ozores, MartÃn Calvelo, Rebeca GarcÃa-Fandiño, Manuel AmorÃn, Nicola Demitri, Giancarlo Terraneo, Silvia Bracco, Angiolina Comotti, Piero Sozzani, Charl X. Bezuidenhout, Pierangelo Metrangolo, Juan R. Granja Tight Xenon Confinement in a Crystalline Sandwich-like Hydrogen-Bonded Dimeric Capsule of a Cyclic Peptide published pages: 14472-14476, ISSN: 1433-7851, DOI: 10.1002/anie.201906599 |
Angewandte Chemie International Edition 58/41 | 2020-02-18 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MINIRES" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MINIRES" are provided by the European Opendata Portal: CORDIS opendata.