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REGENERBONE TERMINATED

REGENERATING LARGE BONE DEFECTS

Total Cost €

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EC-Contrib. €

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Partnership

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 REGENERBONE project word cloud

Explore the words cloud of the REGENERBONE project. It provides you a very rough idea of what is the project "REGENERBONE" about.

basis    market    biomimetic    mechanical    dose    replaced    facial    repair    severe    toward    autograft    peptide    ideally    business    strategies    bone    sourcing    risks    proof    reported    goes    erc    cell    structural    medical    introducing    clinical    metals    appropriate    drawbacks    activation    osteoinductive    molecules    orthopedics    critical    era    ceramics    animals    device    biomim    osteoconductive    supra    innovative    stem    building    regenerbone    adverse    grafts    model    bioactive    efficient    medicine    trigger    defect    maxilla    effect    conducting    reconstruction    shape    maxillo    introduce    pain    frame    deposited    donor    size    successful    personalized    approved    actively    site    components    surgeries    nanomedicine    search    implant    temporally    situ    defects    trials    containing    polymers    appealing    infection    prolonged    orthobiologics    satisfying    architectured    solution    consists    oscodi    material    securing    synthetic    gold    biologics    films    carrier    standard    film    physiological    regeneration    surgery    safe   

Project "REGENERBONE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT POLYTECHNIQUE DE GRENOBLE 

Organization address
address: AVENUE FELIX VIALLET 46
city: GRENOBLE CEDEX 1
postcode: 38031
website: http://www.grenoble-inp.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 149˙998 €
 EC max contribution 149˙998 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT POLYTECHNIQUE DE GRENOBLE FR (GRENOBLE CEDEX 1) coordinator 149˙998.00

Map

 Project objective

In the field of orthopedics and maxillo-facial surgeries, there is still no satisfying solution to repair critical size bone defects. Autograft, which is the current gold standard, presents several drawbacks, including prolonged pain on donor site and higher infection risks. It needs to be replaced by efficient, safe and easy-to-use strategies. Some synthetic bone grafts are providing mechanical and osteoconductive properties, but there is a need to introduce a bioactive molecules, such as a growth factor or a peptide, to trigger actively bone repair. These “orthobiologics” products are appealing since they trigger stem cell activation in situ. There are several approved products containing orthobiologics on the market for bone regeneration, but the physiological delivery of orthobiologics remains a challenge: severe adverse effect have been reported due to the supra-physiological dose of biologics used. In addition these product do not provide structural properties which is necessary for critical size defect reconstruction. Ideally the carrier for the bioactive molecules should be appropriate and enable a spatially/temporally-controlled molecules delivery with physiological dose. Our nanomedicine technology consists of an osteoinductive biomimetic films that can be deposited on architectured implant of any shape and material (ceramics, polymers, metals). The aim of REGENERBONE is to advance our technology toward a clinical application in maxilla-facial surgery and orthopedics. This will be done by conducting pre-clinical trials in large animals, doing a market search, securing the sourcing of the film components and building a business model. The successful results we obtained recently in the frame of the ERC BIOMIM and Proof-of-Concept OSCODI are the basis for REGENERBONE, which goes a step beyond in the long process of introducing an innovative medical device to the market in an era of personalized medicine.

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The information about "REGENERBONE" are provided by the European Opendata Portal: CORDIS opendata.

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