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VALSL

Valorisation of splice-switching oligonucleotides for lung cancer therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 VALSL project word cloud

Explore the words cloud of the VALSL project. It provides you a very rough idea of what is the project "VALSL" about.

context    combination    mechanistic    therapeutic    tumours    recruitment    lack    cell    alone    ranging    bridge    adenocarcinoma    fundamental    here    reagents    innovation    messenger    aligned    society    property    antagonistic    added    chemotherapy    mascp    vitro    class    gene    venture    rnas    funds    protection    splicing    experimental    gap    xenografts    neurodegenerative    optimization    treatments    pathologies    requests    proteins    roles    models    functions    dose    efficient    molecular    route    repress    alternative    goals    proliferation    translate    plays    variety    modifying    alterations    modulate    mechanisms    antisense    administered    company    mouse    prognosis    assets    stakeholders    cancer    intellectual    inhibit    lung    incidence    poc    critical    patient    preclinical    poor    oligonucleotides    therapies    regulation    spin    displaying    mice    single    disease    mechanism    tumour    market    linked    capital    healthcare    plethora    intranasally    erc    successful    off   

Project "VALSL" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO CENTRE DE REGULACIO GENOMICA 

Organization address
address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003
website: www.crg.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙894 €
 EC max contribution 149˙894 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) coordinator 149˙894.00

Map

 Project objective

Here we propose to test the therapeutic potential of a novel class of reagents, known as splicing-modifying antisense oligonucleotides, in preclinical models of lung adenocarcinoma, including patient-derived tumours in mice. Alternative splicing is a major mechanism of gene regulation by which different messenger RNAs and proteins are generated from a single gene, often displaying distinct, even antagonistic functions. Alterations in alternative splicing have been linked with a plethora of pathologies ranging from neurodegenerative disease to cancer. As a result of detailed mechanistic analyses of alternative splicing regulation in the context of the ERC-funded MASCP project, we have identified antisense oligonucleotides that modulate alternative splicing of a gene that plays key roles in the control of lung cancer cell proliferation. These reagents repress cell growth in vitro as well as inhibit tumour growth when administered intranasally in mouse models of lung adenocarcinoma. The main experimental goal of the ERC PoC proposal is to test the therapeutic value of the antisense oligonucleotides in a variety of patient-derived xenografts in mice, alone or in combination with other treatments, including chemotherapy. This will require previous optimization of dose and delivery route, which is being carried out with available support from other healthcare innovation funds. These goals are aligned with requests from various stakeholders, and funding from the ERC PoC program will be critical for successful valorisation of our assets, intellectual property protection and recruitment of venture capital to establish a spin-off company. Given the high incidence, poor prognosis and lack of efficient therapies for lung cancer, the work proposed can translate fundamental knowledge on molecular mechanisms of gene regulation derived from the ERC-funded MASCP project into applications whose valorisation can bridge the gap to market and provide added value for society.

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The information about "VALSL" are provided by the European Opendata Portal: CORDIS opendata.

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