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HybridImmunogenetics SIGNED

Effects of major histocompatibility complex immunogenetic profiles of wild hybrid and non-hybrid marmosets on their susceptibility to arbovirus infections

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HybridImmunogenetics project word cloud

Explore the words cloud of the HybridImmunogenetics project. It provides you a very rough idea of what is the project "HybridImmunogenetics" about.

improvements    augments    introductions    innovation    carriers    hybrid    dengue    chikungunya    caja    cutting    intimately    outbreaks    gives    susceptibility    brazil    edge    parental    intertwined    animal    pillar    region    arboviruses    portable    hypothesis    first    wild    mathematical    harnesses    hybridization    evolution    environmental    links    hybrids    advantage    mhc    immunological    biodiversity    entire    reservoirs    impacted    callithrix    generation    urbanized    genomic    west    brazilian    pathogenic    selective    paradigm    wildlife    nile    composition    borne    admixed    arbovirus    mammalian    infectious    primate    health    susceptible    relationship    stimulate    genus    infections    chance    transmission    anthropogenic    democratizes    guidelines    public    costly    suggests    invigorates    zoonotic    human    monitoring    powerfully    close    genetic    segment    regions    few    disease    natural    models    immune    data    arboviruse    histocompatability    genes    travel    introgression    diversity    exotic    notion    species    additionally    shift    sequencing    class   

Project "HybridImmunogenetics" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES PRIMATENZENTRUM GMBH 

Organization address
address: KELLNERWEG 4
city: GOTTINGEN
postcode: 37077
website: http://www.dpz.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES PRIMATENZENTRUM GMBH DE (GOTTINGEN) coordinator 171˙460.00

Map

 Project objective

Introductions of animal hybrids borne of exotic species and arboviruses represent costly anthropogenic environmental changes. These processes become intertwined if hybrids become arbovirus reservoirs. How does the admixed composition of hybrid immune genes, specifically Major Histocompatability (MHC) class I, affect the hybrid susceptibility to pathogenic disease? A human hybridization study suggests that genetic introgression gives hybrids an immunological selective advantage, but such studies are few. Europe and Brazil have been impacted by arboviruse outbreaks from dengue, chikungunya, and West Nile. Because human travel intimately links these two regions, this close relationship augments the chance of arbovirus transmission between them. Hybrids of the primate Callithrix genus occur in many highly urbanized Brazilian regions of arbovirus outbreaks, and the hybrid parental species are carriers or susceptible to arboviruses infections. Here we propose to adopt emerging, portable sequencing technology to test the hypothesis that hybrids have a selective advantage to infectious disease susceptibility using the classical Callithrix MHC class I Caja-G/F segment. Further we will investigate diversity, natural selection, and genetic introgression at the genomic level and Caja-G/F segment in wild hybrid and non-hybrid Callithrix. By using this entire segment, this study powerfully harnesses the potential of the MHC region as a pillar of evolution studies and invigorates a paradigm shift in how such an important genomic region is studied. Additionally, this project will be the first to apply cutting-edge portable sequencing technology to study mammalian biodiversity, evolution, and wildlife health- a notion that democratizes the generation of genomic data. Finally, the results of the project will stimulate innovation in European and Brazilian zoonotic disease monitoring through improvements to mathematical models of disease transmission and public health guidelines.

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The information about "HYBRIDIMMUNOGENETICS" are provided by the European Opendata Portal: CORDIS opendata.

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