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ORTHOCAT SIGNED

Bioorthogonal Photocatalytic Activation of Metal-Based Prodrugs

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ORTHOCAT project word cloud

Explore the words cloud of the ORTHOCAT project. It provides you a very rough idea of what is the project "ORTHOCAT" about.

photosensitizer    new    kill    clinics    simultaneously    mechanism    pt    mitochondrial    oxygen    prodrug    potentially    outcome    agents    sci    activation    4619    dna    efficacy    designing    generate    innovative    redox    photocatalyst    anticancer    photochemotherapy    reducing    background    complexes    triphenylphosphonium    imbalance    synergistically    employing    fewer    cell    transition    therapy    multidisciplinary    death    activating    combines    orthocat    riboflavin    original    effectiveness    involve    light    catalytic    nevertheless    efficiency    convenient    compounds    depends    trigger    homeostasis    mission    proposes    tumour    photochemistry    photocatalytic    vast    act    prodrugs    patient    photodynamic    action    organelle    accumulate    surgery    nanoplatforms    pdt    hypoxic    singlet    2017    selectivity    cellular    once    care    tumours    vectors    intimately    strategy    dual    inside    photoactivatable    delicate    species    framework    strategies    limits    solid    cancer    unconventional    wellbeing    accomplishes    class    therapeutic    mitochondria    drugs    cells    metal    successful    selectively    chem   

Project "ORTHOCAT" data sheet

The following table provides information about the project.

Coordinator		 FUNDACION DONOSTIA INTERNATIONAL PHYSICS CENTER 

Organization address
address: PASEO MANUEL LARDIZABAL 4
city: DONOSTIA SAN SEBASTIAN
postcode: 20018
website: http://dipc.ehu.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-10   to  2020-09-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION DONOSTIA INTERNATIONAL PHYSICS CENTER ES (DONOSTIA SAN SEBASTIAN) coordinator 158˙121.00

Map

 Project objective

New cancer care methodologies with fewer side effects and no need for major surgery are required to enhance patient wellbeing. Photodynamic Therapy (PDT) partially accomplishes such mission employing light and a photosensitizer. Nevertheless, the PDT mechanism of action intimately depends on oxygen, which limits its efficacy, particularly in hypoxic solid tumours. Promising strategies to improve the impact of PDT in the clinics currently involve the design of photoactivatable transition metal complexes, a class of compounds which combines the rich photochemistry of metal complexes with the vast background of metal-based drugs in cancer therapy.

In this framework, ORTHOCAT proposes an original and multidisciplinary strategy to exploit the efficiency and selectivity of riboflavin as unconventional photocatalyst for the activation of Pt(IV) anticancer prodrugs (Chem. Sci. 2017, 8, 4619).

The project aims at designing novel riboflavin-based catalytic systems capable of activating Pt(IV) anticancer prodrugs inside the mitochondria of tumour cells. In particular, I will use triphenylphosphonium targeting vectors to develop new photocatalytic prodrug systems and delivery nanoplatforms which selectively accumulate in the mitochondria. Once in the organelle, riboflavin will act as singlet oxygen photosensitizer for PDT and simultaneously as photocatalyst to generate Pt(II) species for targeting mitochondrial DNA (photochemotherapy). Imbalance of mitochondrial delicate redox homeostasis by ORTHOCAT dual agents can trigger cell death through convenient cellular pathways. Therefore, ORTHOCAT prodrug systems will synergistically kill cancer cells with increased effectiveness, while potentially reducing side effects of metal-based drugs. Successful outcome of the project has the potential to deliver innovative therapeutic agents for cancer photochemotherapy.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2019-08-05 15:14:49

Take a look to the deliverables list in detail:  detailed list of ORTHOCAT deliverables.

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The information about "ORTHOCAT" are provided by the European Opendata Portal: CORDIS opendata.

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