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rDNAstress SIGNED

Novel insights into DNA damage and stress responses in the nucleolus: Mechanisms and relevance for genomic (in)stability and cancer

Total Cost €

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EC-Contrib. €

0

Partnership

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 rDNAstress project word cloud

Explore the words cloud of the rDNAstress project. It provides you a very rough idea of what is the project "rDNAstress" about.

phenomena    proposes    signalling    functionally    treat    defects    imaging    enhanced    repair    fuels    shared    world    genes    replication    preliminary    live    protein    difficult    synthesis    cells    radiation    endogenous    nucleolus    ddr    cell    dna    data    achilles    repetitive    hypothesis    centers    genome    grave    contains    receiving    body    drugs    innovative    strategies    syndromes    combination    aging    sequences    battle    feasible    technological    cellular    modern    vulnerable    incidence    tumorigenesis    exposed    central    models    exogenous    insights    proteomics    machinery    biogenesis    prevent    premature    rdna    maintenance    oncogenes    genomic    gene    heel    insults    ensuing    stress    human    transcription    diverse    neurodegeneration    functional    age    causal    ribosome    damage    populations    pathologies    guard    unpublished    editing    nucleolar    function    instability    activated    diseases    cancer    technologies    integrity    stresses    copies    transcribed    elucidation    inspire    sensor    chemotherapy    exceptionally    techniques    fact   

Project "rDNAstress" data sheet

The following table provides information about the project.

Coordinator
KRAEFTENS BEKAEMPELSE 

Organization address
address: STRANDBOULEVARDEN 49
city: KOEBENHAVN
postcode: 2100
website: http://www.cancer.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KRAEFTENS BEKAEMPELSE DK (KOEBENHAVN) coordinator 212˙194.00

Map

 Project objective

Incidence of grave pathologies including neurodegeneration and cancer increases in today’s aging European populations and new approaches to battle these diseases are required. Shared by these pathologies and premature aging syndromes is the enhanced DNA damage and genomic instability, likely causal phenomena that can be better understood by functional elucidation of the cellular DNA damage response (DDR) machinery and its defects. The central hypothesis of this project is that ‘nucleolar genome’ that contains many copies of rDNA genes, the repetitive and most highly transcribed genomic sequences essential for ribosome biogenesis and protein synthesis, may represent an exceptionally vulnerable ‘Achilles heel’ of our genome whose instability fuels aging and tumorigenesis. This project proposes to approach this problem by a combination of innovative cellular models and techniques including gene editing, proteomics and live cell imaging, to assess rDNA damage and the ensuing genomic instability in human cells exposed to exogenous (radiation, chemotherapy drugs) and endogenous (replication and transcription stress, ribosome biogenesis stress, activated oncogenes) insults and identify and functionally characterize signalling and ‘repair’ factors that guard nucleolar integrity and function. This proposal is timely due to the emerging concept of nucleolus as a sensor of diverse stresses and the fact that technological advances now allow analysis of the difficult-to-assess rDNA genes. The applicant is experienced in the DDR field and modern technologies, the receiving institute is among the world leading centers in DNA damage, cancer and cell stress research fields. These aspects, together with the large body of preliminary unpublished data makes this ambitious project feasible. The results will provide novel insights into genome integrity maintenance and cell stress responses, and may inspire novel strategies to treat or even prevent age-related diseases, especially cancer.

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The information about "RDNASTRESS" are provided by the European Opendata Portal: CORDIS opendata.

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