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Novel insights into DNA damage and stress responses in the nucleolus: Mechanisms and relevance for genomic (in)stability and cancer

Total Cost €


EC-Contrib. €






 rDNAstress project word cloud

Explore the words cloud of the rDNAstress project. It provides you a very rough idea of what is the project "rDNAstress" about.

guard    oncogenes    populations    functional    strategies    stress    prevent    receiving    signalling    repair    endogenous    innovative    pathologies    insults    functionally    combination    proteomics    transcription    repetitive    genomic    elucidation    activated    modern    enhanced    tumorigenesis    technological    phenomena    function    imaging    diseases    stresses    central    editing    cells    preliminary    causal    world    dna    centers    insights    synthesis    exogenous    nucleolar    fact    ribosome    live    sensor    models    cell    exposed    shared    data    genome    contains    protein    radiation    genes    human    cancer    damage    feasible    techniques    treat    ddr    inspire    fuels    maintenance    exceptionally    proposes    incidence    achilles    copies    ensuing    aging    biogenesis    body    nucleolus    instability    grave    diverse    difficult    battle    premature    defects    integrity    unpublished    age    vulnerable    machinery    heel    rdna    sequences    neurodegeneration    replication    chemotherapy    cellular    transcribed    gene    technologies    syndromes    hypothesis    drugs   

Project "rDNAstress" data sheet

The following table provides information about the project.


Organization address
postcode: 2100

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KRAEFTENS BEKAEMPELSE DK (KOEBENHAVN) coordinator 212˙194.00


 Project objective

Incidence of grave pathologies including neurodegeneration and cancer increases in today’s aging European populations and new approaches to battle these diseases are required. Shared by these pathologies and premature aging syndromes is the enhanced DNA damage and genomic instability, likely causal phenomena that can be better understood by functional elucidation of the cellular DNA damage response (DDR) machinery and its defects. The central hypothesis of this project is that ‘nucleolar genome’ that contains many copies of rDNA genes, the repetitive and most highly transcribed genomic sequences essential for ribosome biogenesis and protein synthesis, may represent an exceptionally vulnerable ‘Achilles heel’ of our genome whose instability fuels aging and tumorigenesis. This project proposes to approach this problem by a combination of innovative cellular models and techniques including gene editing, proteomics and live cell imaging, to assess rDNA damage and the ensuing genomic instability in human cells exposed to exogenous (radiation, chemotherapy drugs) and endogenous (replication and transcription stress, ribosome biogenesis stress, activated oncogenes) insults and identify and functionally characterize signalling and ‘repair’ factors that guard nucleolar integrity and function. This proposal is timely due to the emerging concept of nucleolus as a sensor of diverse stresses and the fact that technological advances now allow analysis of the difficult-to-assess rDNA genes. The applicant is experienced in the DDR field and modern technologies, the receiving institute is among the world leading centers in DNA damage, cancer and cell stress research fields. These aspects, together with the large body of preliminary unpublished data makes this ambitious project feasible. The results will provide novel insights into genome integrity maintenance and cell stress responses, and may inspire novel strategies to treat or even prevent age-related diseases, especially cancer.

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The information about "RDNASTRESS" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2020-08-11 0:22:26) correctly updated