Opendata, web and dolomites

PHOTO-FLUOR

Enantioselective Carbon-Fluorine Bond Formation: A Molecular Editing Approach toward Drug Discovery

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PHOTO-FLUOR project word cloud

Explore the words cloud of the PHOTO-FLUOR project. It provides you a very rough idea of what is the project "PHOTO-FLUOR" about.

skills    pharma    group    training    installation    host    merge    molecular    bond    metal    derivatives    forge    health    editing    mediated    milestones    degradation    expertise    photochemical    combine    immediately    expand    reactions    biological    active    molecules    light    site    photocatalysis    move    excellent    competencies    collaborations    central    paths    plan    link    techniques    place    enantioselective    boost    transition    candidates    carbon    envisaged    substrates    organofluorine    stereogenicity    edited    alkene    discovery    transfer    substrate    fluorine    metabolic    soft    cultural    groups    provides    versatile    position    nature    complicate    bioactive    ing    career    scientific    compounds    desired    visible    transferred    company    limited    materials    alkane    fluor    feedstock    internationally    chemistry    excellence    amenable    pool    photo    fellow    organocatalysis    play    catalysis    secondment    biopharmaceuticals    catalytic    background    selective    drug    fluorination    conducting    broaden    potency   

Project "PHOTO-FLUOR" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-09   to  2020-05-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 170˙121.00

Map

 Project objective

The unique properties of the carbon-fluorine (C-F) bond explain why organofluorine compounds play a central role in biopharmaceuticals. One current challenge in drug discovery is the selective installation of C-F stereogenicity within the active site of lead candidates, such molecular editing may greatly help in increasing potency and understanding metabolic degradation paths. However, the limited C-F bond formation techniques complicate this approach and providing new versatile catalytic techniques, which can expand the substrate pool amenable to C-F bond formation, would greatly boost the impact of fluorine chemistry in drug discovery. We aim at developing methods that require feedstock materials as substrates, such as alkene and alkane derivatives. The new methods will combine the potential of enantioselective organocatalysis or metal-mediated processes with visible light photocatalysis. The PHOTO-FLUOR project is unique in that it provides training in “enantioselective fluorination” and “catalysis applied to drug discovery”, areas that contribute to European excellence. The resulting techniques may immediately impact the EU Health sector. PHOTO-FLUOR will merge the expertise of the host group in photochemical enantioselective reactions with the background of the applicant in transition metal catalysis, to reach the desired deliverables and milestones. In addition, a secondment at an internationally recognized pharma-company has been included in the work plan for conducting biological study of the fluorine-edited bioactive molecules. The applicant will transfer knowledge to both host groups creating a link between them to forge future collaborations. Finally, an ambitious training program, which includes a number of new scientific and soft skills to be transferred to the applicant, is also envisaged. The multi-cultural nature of this project will greatly broaden the fellow competencies and will place him in an excellent position for the next career move.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PHOTO-FLUOR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PHOTO-FLUOR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Au-MLC (2019)

Cooperative Au catalysis with chemically non-innocent ligands.

Read More  

PEPREP (2019)

Peptide based self-replicating coacervate protocells

Read More  

NUTRIENT (2020)

Identification of physiological and molecular mechanisms mediating the response of Nitrogen nutrition to eCO2

Read More