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Enantioselective Carbon-Fluorine Bond Formation: A Molecular Editing Approach toward Drug Discovery

Total Cost €


EC-Contrib. €






 PHOTO-FLUOR project word cloud

Explore the words cloud of the PHOTO-FLUOR project. It provides you a very rough idea of what is the project "PHOTO-FLUOR" about.

organocatalysis    fellow    complicate    fluor    expand    degradation    expertise    paths    play    milestones    background    materials    drug    light    carbon    alkane    soft    stereogenicity    selective    visible    conducting    excellent    career    training    chemistry    nature    collaborations    skills    discovery    link    catalysis    organofluorine    transition    mediated    fluorination    broaden    bond    fluorine    transfer    substrates    biopharmaceuticals    reactions    enantioselective    internationally    bioactive    photochemical    combine    molecules    scientific    photocatalysis    biological    competencies    potency    ing    envisaged    provides    merge    transferred    photo    plan    company    substrate    active    central    cultural    group    metabolic    edited    place    excellence    immediately    pool    move    derivatives    editing    site    compounds    secondment    desired    techniques    catalytic    versatile    amenable    health    metal    groups    host    limited    boost    alkene    position    molecular    installation    forge    pharma    feedstock    candidates   

Project "PHOTO-FLUOR" data sheet

The following table provides information about the project.


Organization address
postcode: 43007

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-09   to  2020-05-08


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The unique properties of the carbon-fluorine (C-F) bond explain why organofluorine compounds play a central role in biopharmaceuticals. One current challenge in drug discovery is the selective installation of C-F stereogenicity within the active site of lead candidates, such molecular editing may greatly help in increasing potency and understanding metabolic degradation paths. However, the limited C-F bond formation techniques complicate this approach and providing new versatile catalytic techniques, which can expand the substrate pool amenable to C-F bond formation, would greatly boost the impact of fluorine chemistry in drug discovery. We aim at developing methods that require feedstock materials as substrates, such as alkene and alkane derivatives. The new methods will combine the potential of enantioselective organocatalysis or metal-mediated processes with visible light photocatalysis. The PHOTO-FLUOR project is unique in that it provides training in “enantioselective fluorination” and “catalysis applied to drug discovery”, areas that contribute to European excellence. The resulting techniques may immediately impact the EU Health sector. PHOTO-FLUOR will merge the expertise of the host group in photochemical enantioselective reactions with the background of the applicant in transition metal catalysis, to reach the desired deliverables and milestones. In addition, a secondment at an internationally recognized pharma-company has been included in the work plan for conducting biological study of the fluorine-edited bioactive molecules. The applicant will transfer knowledge to both host groups creating a link between them to forge future collaborations. Finally, an ambitious training program, which includes a number of new scientific and soft skills to be transferred to the applicant, is also envisaged. The multi-cultural nature of this project will greatly broaden the fellow competencies and will place him in an excellent position for the next career move.

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The information about "PHOTO-FLUOR" are provided by the European Opendata Portal: CORDIS opendata.

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