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PHOTO-FLUOR

Enantioselective Carbon-Fluorine Bond Formation: A Molecular Editing Approach toward Drug Discovery

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PHOTO-FLUOR project word cloud

Explore the words cloud of the PHOTO-FLUOR project. It provides you a very rough idea of what is the project "PHOTO-FLUOR" about.

alkene    skills    selective    metal    mediated    pool    installation    molecules    organocatalysis    ing    site    provides    organofluorine    place    secondment    limited    central    scientific    combine    fluorine    reactions    transfer    carbon    conducting    bioactive    techniques    career    catalysis    stereogenicity    broaden    background    photochemical    editing    position    excellence    group    photocatalysis    fellow    active    boost    photo    soft    potency    edited    desired    fluor    light    compounds    groups    excellent    paths    biological    bond    company    collaborations    transferred    enantioselective    drug    fluorination    metabolic    immediately    envisaged    nature    amenable    link    degradation    transition    cultural    competencies    chemistry    move    substrate    materials    expand    feedstock    complicate    molecular    forge    play    catalytic    host    training    internationally    milestones    discovery    alkane    merge    substrates    derivatives    visible    pharma    health    plan    biopharmaceuticals    candidates    expertise    versatile   

Project "PHOTO-FLUOR" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-09   to  2020-05-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 170˙121.00

Map

 Project objective

The unique properties of the carbon-fluorine (C-F) bond explain why organofluorine compounds play a central role in biopharmaceuticals. One current challenge in drug discovery is the selective installation of C-F stereogenicity within the active site of lead candidates, such molecular editing may greatly help in increasing potency and understanding metabolic degradation paths. However, the limited C-F bond formation techniques complicate this approach and providing new versatile catalytic techniques, which can expand the substrate pool amenable to C-F bond formation, would greatly boost the impact of fluorine chemistry in drug discovery. We aim at developing methods that require feedstock materials as substrates, such as alkene and alkane derivatives. The new methods will combine the potential of enantioselective organocatalysis or metal-mediated processes with visible light photocatalysis. The PHOTO-FLUOR project is unique in that it provides training in “enantioselective fluorination” and “catalysis applied to drug discovery”, areas that contribute to European excellence. The resulting techniques may immediately impact the EU Health sector. PHOTO-FLUOR will merge the expertise of the host group in photochemical enantioselective reactions with the background of the applicant in transition metal catalysis, to reach the desired deliverables and milestones. In addition, a secondment at an internationally recognized pharma-company has been included in the work plan for conducting biological study of the fluorine-edited bioactive molecules. The applicant will transfer knowledge to both host groups creating a link between them to forge future collaborations. Finally, an ambitious training program, which includes a number of new scientific and soft skills to be transferred to the applicant, is also envisaged. The multi-cultural nature of this project will greatly broaden the fellow competencies and will place him in an excellent position for the next career move.

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The information about "PHOTO-FLUOR" are provided by the European Opendata Portal: CORDIS opendata.

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