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PHOTO-FLUOR

Enantioselective Carbon-Fluorine Bond Formation: A Molecular Editing Approach toward Drug Discovery

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PHOTO-FLUOR project word cloud

Explore the words cloud of the PHOTO-FLUOR project. It provides you a very rough idea of what is the project "PHOTO-FLUOR" about.

training    provides    scientific    metabolic    health    site    alkane    combine    expertise    central    company    reactions    fellow    alkene    photocatalysis    organocatalysis    group    transferred    substrates    photochemical    link    broaden    cultural    feedstock    collaborations    drug    bioactive    edited    carbon    move    catalytic    merge    mediated    degradation    molecules    transfer    transition    soft    biopharmaceuticals    techniques    background    catalysis    pool    biological    bond    skills    metal    desired    editing    organofluorine    versatile    secondment    active    expand    complicate    position    immediately    molecular    materials    plan    candidates    milestones    nature    light    competencies    installation    envisaged    photo    discovery    fluorination    stereogenicity    amenable    compounds    substrate    paths    limited    fluorine    visible    groups    excellent    career    internationally    conducting    potency    place    play    fluor    boost    forge    ing    chemistry    derivatives    host    pharma    selective    excellence    enantioselective   

Project "PHOTO-FLUOR" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-09   to  2020-05-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 170˙121.00

Map

 Project objective

The unique properties of the carbon-fluorine (C-F) bond explain why organofluorine compounds play a central role in biopharmaceuticals. One current challenge in drug discovery is the selective installation of C-F stereogenicity within the active site of lead candidates, such molecular editing may greatly help in increasing potency and understanding metabolic degradation paths. However, the limited C-F bond formation techniques complicate this approach and providing new versatile catalytic techniques, which can expand the substrate pool amenable to C-F bond formation, would greatly boost the impact of fluorine chemistry in drug discovery. We aim at developing methods that require feedstock materials as substrates, such as alkene and alkane derivatives. The new methods will combine the potential of enantioselective organocatalysis or metal-mediated processes with visible light photocatalysis. The PHOTO-FLUOR project is unique in that it provides training in “enantioselective fluorination” and “catalysis applied to drug discovery”, areas that contribute to European excellence. The resulting techniques may immediately impact the EU Health sector. PHOTO-FLUOR will merge the expertise of the host group in photochemical enantioselective reactions with the background of the applicant in transition metal catalysis, to reach the desired deliverables and milestones. In addition, a secondment at an internationally recognized pharma-company has been included in the work plan for conducting biological study of the fluorine-edited bioactive molecules. The applicant will transfer knowledge to both host groups creating a link between them to forge future collaborations. Finally, an ambitious training program, which includes a number of new scientific and soft skills to be transferred to the applicant, is also envisaged. The multi-cultural nature of this project will greatly broaden the fellow competencies and will place him in an excellent position for the next career move.

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