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DEgradation TRIggered by MOdular DEsign

Total Cost €


EC-Contrib. €






 DETRIMODE project word cloud

Explore the words cloud of the DETRIMODE project. It provides you a very rough idea of what is the project "DETRIMODE" about.

therapeutic    methodology    affinity    ec    articulated    competence    chemical    grow    proximity    latter    linker    molecule    peers    company    tackles    recruitment    proteins    synthetic    entities    tripartite    proteasome    ternary    biology    detrimode    disease    ligand    ligands    cell    stages    composition    influenced    inducers    computational    exploited    pursued    outcomes    science    intermediates    degradation    nms    efficiency    multidisciplinary    updates    organic    ligase    ubiquitin    close    comprised    progressively    degradationtriggered    bifunctional    molecular    chance    solid    communicated    joined    progresses    length    tpdi    endeavour    apt    modular    engaged    protein    shared    closer    medchem    scope    incrementing    speed    mutual    variety    structural    protected    drugs    molecules    combinable    series    arrays    purinome    synthesis    environment    dept    chemistry    core    flexibility    public    society    e3    innovation    researcher    spacer    tpdis    technologies    discovery    small    ubiquitinating    grafted    oncology    prospects    driving    designed   

Project "DETRIMODE" data sheet

The following table provides information about the project.


Organization address
postcode: 20014

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-05-21   to  2020-07-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NERVIANO MEDICAL SCIENCES S.R.L IT (NERVIANO) coordinator 168˙277.00


 Project objective

The project DETRIMODE (DEgradationTRIggered by MOdular Design) aims at the development of a methodology for the modular synthesis of Targeted Protein Degradation Inducers (TPDI), designed as bifunctional molecules apt to the degradation of target proteins via recruitment of the ubiquitin proteasome system, a process with therapeutic prospects if applied to disease driving proteins. TPDIs are comprised of an E3 ligase ligand and a target protein ligand joined by a spacer (linker), to bring the ubiquitinating system and the target protein in close proximity, so to promote degradation of the latter. The formation of the ternary complex (target protein-TPDI-E3 ligase) is an articulated process influenced by a series of factors, such as ligands affinity, linker length and composition and molecular features of the proteins involved. The project tackles this endeavour in stages of increasing innovation, progressively incrementing the scope, flexibility and efficiency of modular synthetic access to arrays of tripartite molecules via protected, solid grafted intermediates, combinable with a variety of target ligands. New chemical entities TPDIs will be generated targeting selected purinome proteins oncology-related. This project will be pursued within the Chemical Core Technologies Dept. of a fully integrated company (NMS), engaged in the discovery and development of new small molecule based drugs. Organic and solid phase chemistry, computational and structural chemistry, molecular and cell biology, among others, will be exploited to achieve the project’s goal. In such multidisciplinary environment, this new technology will grow at the same speed with the researcher’s medchem competence, increasing the chance of mutual success. DETRIMODE outcomes will be shared with peers, while updates on its progresses as well as general information on how EC-funded research have impact on the general public will be communicated by a number of means, bringing science closer to society

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The information about "DETRIMODE" are provided by the European Opendata Portal: CORDIS opendata.

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