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DEgradation TRIggered by MOdular DEsign

Total Cost €


EC-Contrib. €






 DETRIMODE project word cloud

Explore the words cloud of the DETRIMODE project. It provides you a very rough idea of what is the project "DETRIMODE" about.

proteins    structural    apt    stages    entities    molecular    disease    organic    incrementing    tpdi    mutual    cell    modular    technologies    methodology    e3    arrays    oncology    ligand    ec    peers    chance    detrimode    discovery    progressively    linker    communicated    articulated    composition    computational    dept    multidisciplinary    therapeutic    researcher    spacer    solid    progresses    environment    science    molecules    ubiquitin    close    competence    affinity    tpdis    joined    influenced    ternary    grow    flexibility    speed    tripartite    inducers    comprised    intermediates    tackles    synthesis    combinable    small    bifunctional    series    degradationtriggered    degradation    ligands    proximity    grafted    biology    endeavour    nms    public    engaged    protected    ubiquitinating    pursued    driving    synthetic    medchem    company    molecule    exploited    protein    core    chemistry    designed    latter    purinome    recruitment    length    closer    outcomes    prospects    efficiency    scope    variety    ligase    society    updates    innovation    proteasome    shared    chemical    drugs   

Project "DETRIMODE" data sheet

The following table provides information about the project.


Organization address
postcode: 20014

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-05-21   to  2020-07-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NERVIANO MEDICAL SCIENCES S.R.L IT (NERVIANO) coordinator 168˙277.00


 Project objective

The project DETRIMODE (DEgradationTRIggered by MOdular Design) aims at the development of a methodology for the modular synthesis of Targeted Protein Degradation Inducers (TPDI), designed as bifunctional molecules apt to the degradation of target proteins via recruitment of the ubiquitin proteasome system, a process with therapeutic prospects if applied to disease driving proteins. TPDIs are comprised of an E3 ligase ligand and a target protein ligand joined by a spacer (linker), to bring the ubiquitinating system and the target protein in close proximity, so to promote degradation of the latter. The formation of the ternary complex (target protein-TPDI-E3 ligase) is an articulated process influenced by a series of factors, such as ligands affinity, linker length and composition and molecular features of the proteins involved. The project tackles this endeavour in stages of increasing innovation, progressively incrementing the scope, flexibility and efficiency of modular synthetic access to arrays of tripartite molecules via protected, solid grafted intermediates, combinable with a variety of target ligands. New chemical entities TPDIs will be generated targeting selected purinome proteins oncology-related. This project will be pursued within the Chemical Core Technologies Dept. of a fully integrated company (NMS), engaged in the discovery and development of new small molecule based drugs. Organic and solid phase chemistry, computational and structural chemistry, molecular and cell biology, among others, will be exploited to achieve the project’s goal. In such multidisciplinary environment, this new technology will grow at the same speed with the researcher’s medchem competence, increasing the chance of mutual success. DETRIMODE outcomes will be shared with peers, while updates on its progresses as well as general information on how EC-funded research have impact on the general public will be communicated by a number of means, bringing science closer to society

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The information about "DETRIMODE" are provided by the European Opendata Portal: CORDIS opendata.

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