Opendata, web and dolomites


DEgradation TRIggered by MOdular DEsign

Total Cost €


EC-Contrib. €






 DETRIMODE project word cloud

Explore the words cloud of the DETRIMODE project. It provides you a very rough idea of what is the project "DETRIMODE" about.

grafted    oncology    close    shared    proximity    recruitment    comprised    incrementing    purinome    cell    modular    endeavour    core    degradation    proteins    dept    tpdis    joined    articulated    chemistry    discovery    speed    progresses    engaged    pursued    variety    therapeutic    society    tpdi    synthetic    mutual    competence    drugs    ligand    company    detrimode    efficiency    computational    solid    molecule    length    spacer    stages    driving    e3    peers    entities    outcomes    ligands    apt    science    progressively    public    tripartite    grow    multidisciplinary    updates    linker    exploited    affinity    closer    protected    nms    chance    prospects    technologies    molecular    medchem    protein    influenced    tackles    structural    synthesis    bifunctional    ternary    designed    ligase    innovation    inducers    combinable    arrays    researcher    chemical    biology    series    composition    flexibility    scope    small    communicated    proteasome    organic    environment    disease    ubiquitin    ubiquitinating    latter    ec    degradationtriggered    intermediates    molecules    methodology   

Project "DETRIMODE" data sheet

The following table provides information about the project.


Organization address
postcode: 20014

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-05-21   to  2020-07-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NERVIANO MEDICAL SCIENCES S.R.L IT (NERVIANO) coordinator 168˙277.00


 Project objective

The project DETRIMODE (DEgradationTRIggered by MOdular Design) aims at the development of a methodology for the modular synthesis of Targeted Protein Degradation Inducers (TPDI), designed as bifunctional molecules apt to the degradation of target proteins via recruitment of the ubiquitin proteasome system, a process with therapeutic prospects if applied to disease driving proteins. TPDIs are comprised of an E3 ligase ligand and a target protein ligand joined by a spacer (linker), to bring the ubiquitinating system and the target protein in close proximity, so to promote degradation of the latter. The formation of the ternary complex (target protein-TPDI-E3 ligase) is an articulated process influenced by a series of factors, such as ligands affinity, linker length and composition and molecular features of the proteins involved. The project tackles this endeavour in stages of increasing innovation, progressively incrementing the scope, flexibility and efficiency of modular synthetic access to arrays of tripartite molecules via protected, solid grafted intermediates, combinable with a variety of target ligands. New chemical entities TPDIs will be generated targeting selected purinome proteins oncology-related. This project will be pursued within the Chemical Core Technologies Dept. of a fully integrated company (NMS), engaged in the discovery and development of new small molecule based drugs. Organic and solid phase chemistry, computational and structural chemistry, molecular and cell biology, among others, will be exploited to achieve the project’s goal. In such multidisciplinary environment, this new technology will grow at the same speed with the researcher’s medchem competence, increasing the chance of mutual success. DETRIMODE outcomes will be shared with peers, while updates on its progresses as well as general information on how EC-funded research have impact on the general public will be communicated by a number of means, bringing science closer to society

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The information about "DETRIMODE" are provided by the European Opendata Portal: CORDIS opendata.

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